The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
Open accessAbstract
Significance: Mitochondrial fission is critical for mammalian cell division, mitophagy, and development. Fission initiates via recruitment of dynamin-related GTPases to the mitochondrial surface. In yeast and human, the recruitment utilizes adaptors that differ in sequence and predicted structure. Key unresolved issues are whether these adaptors function independently in membrane recruitment and whether a single adaptor and GTPase are sufficient to catalyze scission. We show that three human adaptors work interchangeably with a single mitochondrial dynamin to accomplish fission. We also show that an adaptor alters the architecture of the dynamin polymer in a manner that could facilitate membrane constriction and severing.
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Citations
Cites
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · cited 1×
“Drp1 (1) : MiD49 (1) Drp1 (5) : MiD49 (1) Drp1 (10) : MiD49 (1) A”
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., & Mihara, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607279200 · Cited by 1,226
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
Cereghetti, G. M., Stangherlin, A., de Brito, O. M., Chang, C. R., Blackstone, C., Bernardi, P., & Scorrano, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808249105 · Cited by 1,129
Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007152 · Cited by 1,110 · cited 4×
“Instead, Drp1 recruitment is mediated by mitochondrial fission factor (Mff), another tailanchored protein (22, 23).”
BackgroundResultInfluentialS-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092
The Interplay Between Mitochondrial Dynamics and Mitophagy
Twig, G., & Shirihai, O. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3779 · Cited by 778
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., Iijima, M., & Sesaki, H. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903065 · Cited by 667
MiD49 and MiD51, new components of the mitochondrial fission machinery
Palmer, C. S., Osellame, L. D., Laine, D., Koutsopoulos, O. S., Frazier, A. E., & Ryan, M. T. (2011) · The EMBO Reports · doi:10.1038/embor.2011.54 · Cited by 649 · cited 4×
“This aggregated mitochondrial phenotype also was observed when MiD49 and MiD51 were overexpressed in mammalian cells (24).”
BackgroundInfluentialDynamin-like protein 1 is involved in peroxisomal fission
Koch, A., Thiemann, M., Grabenbauer, M., Yoon, Y., McNiven, M. A., & Schrader, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211761200 · Cited by 374
Cited by
Mitochondrial dynamics: overview of molecular mechanisms
Tilokani, L., Nagashima, S., Paupe, V., & Prudent, J. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170104 · Cited by 1,397
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele, T., Rey, T., Winter, J., Zaganelli, S., Mahecic, D., Perreten Lambert, H., Ruberto, F. P., Nemir, M., Wai, T., Pedrazzini, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03510-6 · Cited by 794
Function and regulation of the divisome for mitochondrial fission
Kraus, F., Roy, K., Pucadyil, T. J., & Ryan, M. T. (2021) · Nature · doi:10.1038/s41586-021-03214-x · Cited by 445
Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission
Osellame, L. D., Singh, A. P., Stroud, D. A., Palmer, C. S., Stojanovski, D., Ramachandran, R., & Ryan, M. T. (2016) · Journal of Cell Science · doi:10.1242/jcs.185165 · Cited by 336
Palmer, C. S., Elgass, K. D., Parton, R. G., Osellame, L. D., Stojanovski, D., & Ryan, M. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479873 · Cited by 301
Metadata
- Authors
- Koirala, S., Guo, Q., Kalia, R., Bui, H. T., Eckert, D. M., Frost, A., & Shaw, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-03-25
- Volume
- 110
- Issue
- 15
- Pages
- E1342-51
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137124210
- Cited by
- 193
- References
- 11
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Koirala, S., Guo, Q., Kalia, R., Bui, H. T., Eckert, D. M., Frost, A., & Shaw, J. M. (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1300855110
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