Dynamin-like protein 1 is involved in peroxisomal fission
Open accessAbstract
The mammalian dynamin-like protein 1 (DLP1), a member of the dynamin family of large GTPases, possesses mechanochemical properties known to constrict and tubulate membranes. In this study, we have combined two experimental approaches, induction of peroxisome proliferation by Pex11pbeta and expression of dominant-negative mutants, to test whether DLP1 plays a role in peroxisomal growth and division. We were able to localize DLP1 in spots on tubular peroxisomes in HepG2 cells. In addition, immunoblot analysis revealed the presence of DLP1 in highly purified peroxisomal fractions from rat liver and an increase of DLP1 after treatment of rats with the peroxisome proliferator bezafibrate. Expression of a dominant negative DLP1 mutant deficient in GTP hydrolysis (K38A) either alone or in combination with Pex11pbeta caused the appearance of tubular peroxisomes but had no influence on their intracellular distribution. In co-expressing cells, the formation of tubulo-reticular networks of peroxisomes was promoted, and peroxisomal division was completely inhibited. These findings were confirmed by silencing of DLP1 using siRNA. We propose a direct role for the dynamin-like protein DLP1 in peroxisomal fission and in the maintenance of peroxisomal morphology in mammalian cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Propagation of existing peroxisomes can proceed through self-replication, initiated with PEX11β-dependent elongation of peroxisomal membranes and followed by fission mediated by PEX11β activation of DLP-1.
“Propagation of existing peroxisomes can also proceed through self-replication, initiated with PEX11β-dependent elongation of peroxisomal membranes, and followed by fission mediated by PEX11β activation of the GTPase dynamin-like protein 1, DLP-1 (Koch et al., 2003).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Koch et al., 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456 · see citing works
Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938 · see citing works
A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASE
Cooperstein, S. J., & Lazarow, A. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)44883-1 · Cited by 1,356 · see citing works
Fischer, D., Bieber, T., Li, Y., Elsässer, H., & Kissel, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1014861900478 · Cited by 1,219 · see citing works
Lazarow, P. B., & Fujiki, Y. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.002421 · Cited by 1,114 · see citing works
van den BOSCH, H., Schutgens, R. B. H., Wanders, R. J. A., & Tager, J. M. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.001105 · Cited by 844 · see citing works
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
Bleazard, W., McCaffery, J. M., King, E. J., Bale, S., Mozdy, A. D., Tieu, Q., Nunnari, J. M., & Shaw, J. M. (1999) · Nature Cell Biology · doi:10.1038/13014 · Cited by 795 · see citing works
A Human Dynamin-related Protein Controls the Distribution of Mitochondria
Смирнова, Е. А., Shurland, D., Ryazantsev, S. N., & van der Bliek, A. M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.351 · Cited by 734 · see citing works
Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation
Sweitzer, S. M., & Hinshaw, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81207-6 · Cited by 682 · see citing works
C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane
Labrousse, A. M., Zappaterra, M. D., Rube, D. A., & van der Bliek, A. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80391-3 · Cited by 670 · see citing works
Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis
Takei, K., Slepnev, V. I., Haucke, V., & Camilli, P. V. D. (1999) · Nature Cell Biology · doi:10.1038/9004 · Cited by 657 · see citing works
Baudhuin, P., Beaufay, H., Rahman-Li, Y., Sellinger, O. Z., Wattiaux, R., Jacques, P., & Duve, C. D. (1964) · Biochemical Journal · doi:10.1042/bj0920179 · Cited by 646 · see citing works
Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape
Sesaki, H., & Jensen, R. E. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.699 · Cited by 531 · see citing works
The Machinery of Mitochondrial Inheritance and Behavior
Yaffe, M. P. (1999) · Science · doi:10.1126/science.283.5407.1493 · Cited by 496 · see citing works
The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast
Otsuga, D., Keegan, B. R., Brisch, E., Thatcher, J. W., Hermann, G. J., Bleazard, W., & Shaw, J. M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.333 · Cited by 423 · see citing works
Reddy, J. K., & Mannaerts, G. P. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002015 · Cited by 418 · see citing works
Stowell, M. H. B., Marks, B., Wigge, P., & McMahon, H. T. (1999) · Nature Cell Biology · doi:10.1038/8997 · Cited by 378 · see citing works
The dynamin family of mechanoenzymes: pinching in new places
McNiven, M. A., Cao, H., Pitts, K. R., & Yoon, Y. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01538-8 · Cited by 343 · see citing works
Self-citationGeneration of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes
Takei, K., Haucke, V., Slepnev, V. I., Farsad, K., Salazar, M. A. G., Chen, H., & Camilli, P. V. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81228-3 · Cited by 340 · see citing works
Purdue, P. E., & Lazarow, P. B. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.701 · Cited by 323 · see citing works
Pitts, K. R., Yoon, Y., Krueger, E. W., & McNiven, M. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.12.4403 · Cited by 311 · see citing works
Self-citationHoepfner, D., van den Berg, M., Philippsen, P., Tabak, H. F., & Hettema, E. H. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107028 · Cited by 303 · see citing works
Erdmann, R., & Blobel, G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.4.509 · Cited by 302 · see citing works
Mammalian Dynamin-like Protein DLP1 Tubulates Membranes
Yoon, Y., Pitts, K. R., & McNiven, M. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2894 · Cited by 285 · see citing works
Self-citationExpression of PEX11β Mediates Peroxisome Proliferation in the Absence of Extracellular Stimuli
Schrader, M., Reuber, B. E., Morrell, J. C., Jimenez-Sanchez, G., Obie, C., Stroh, T. A., Valle, D., Schroer, T. A., & Gould, S. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29607 · Cited by 266 · see citing works
Self-citationANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER
Beaufay, H., Amar-Costesec, A., Thinès-Sempoux, D., et al. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.61.1.213 · Cited by 253 · see citing works
Peroxisome Synthesis in the Absence of Preexisting Peroxisomes
South, S. T., & Gould, S. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.2.255 · Cited by 241 · see citing works
Pmp27 promotes peroxisomal proliferation.
Marshall, P. A., Krimkevich, Y., Lark, R. H., Dyer, J. M., Marten Veenhuis, A., & Goodman, J. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.2.345 · Cited by 205 · see citing works
Dynamin family of mechanoenzymes
Danino, D., & Hinshaw, J. E. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00236-2 · Cited by 196 · see citing works
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.
Cook, T. A., Urrutia, R. A., & McNiven, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.644 · Cited by 190 · see citing works
Self-citationYoon, Y., Pitts, K. R., Dahan, S., & McNiven, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.779 · Cited by 183 · see citing works
Self-citationDifferential expression and regulation of multiple dynamins.
Sontag, J. M., Fykse, E. M., Ushkaryov, Y. A., Liu, J., Robinson, P. J., & Südhof, T. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41812-6 · Cited by 175 · see citing works
McNiven, M. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81414-2 · Cited by 174 · see citing works
Self-citationPEX11 promotes peroxisome division independently of peroxisome metabolism
Li, X., & Gould, S. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112028 · Cited by 159 · see citing works
Li, X., Baumgart‐Vogt, E., Dong, G.-X., Morrell, J. C., Jiménez‐Sánchez, G., Valle, D. L., Smith, K. D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.23.8226-8240.2002 · Cited by 157 · see citing works
Inhibitors of Copi and Copii Do Not Block PEX3-Mediated Peroxisome Synthesis
South, S. T., Sacksteder, K. A., Li, X., Liu, Y., & Gould, S. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.7.1345 · Cited by 150 · see citing works
van Roermund, C. W. T., Tabak, H. F., van den Berg, M., Wanders, R. J. A., & Hettema, E. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.489 · Cited by 141 · see citing works
Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin
Cao, H., Krueger, E. W., & McNiven, M. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1993 · Cited by 136 · see citing works
Self-citationPeroxisome Biogenesis: Involvement of ARF and Coatomer
Paßreiter, M., Anton, M., Lay, D., Frank, R. W., Harter, C., Wieland, F., Gorgas, K., & Just, W. W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.373 · Cited by 135 · see citing works
Dynamics of peroxisome assembly and function
Titorenko, V. I. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01865-1 · Cited by 132 · see citing works
Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p
Lorenz, P., Maier, A. G., Baumgart‐Vogt, E., Erdmann, R., & CLAYTON, C. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3542 · Cited by 125 · see citing works
Isolation and characterization of peroxisomes from the liver of normal untreated rats
Völkl, A., & Fahimi, H. D. (1985) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1985.tb08920.x · Cited by 124 · see citing works
Imoto, M., Tachibana, I., & Urrutia, R. A. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1341 · Cited by 109 · see citing works
Real time imaging reveals a peroxisomal reticulum in living cells
Schrader, M., King, S. J., Schrader, T. A., & Schroer, T. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3663 · Cited by 107 · see citing works
Self-citationA novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis
Nakata, T., Takemura, R., & Hirokawa, N. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.1.1 · Cited by 105 · see citing works
Dynamin Is Membrane-Active: Lipid Insertion Is Induced by Phosphoinositides and Phosphatidic Acid
Burger, K. N. J., DEMEL, R. A., Schmid, S. L., et al. (2000) · Biochemistry · doi:10.1021/bi000971r · Cited by 101 · see citing works
Schrader, M., Burkhardt, J. K., Baumgart‐Vogt, E., Lüers, G. H., Spring, H., Völkl, A., & Fahimi, H. D. (1996) · PubMed · Cited by 98 · see citing works
Self-citationLüers, G. H., Hashimoto, T., Fahimi, H. D., & Völkl, A. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.6.1271 · Cited by 94 · see citing works
Beier, K., Völkl, A., Hashimoto, T., & Fahimi, H. D. (1988) · PubMed · Cited by 84 · see citing works
Waterham, H. R., Titorenko, V. I., Swaving, G. J., et al. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06167.x · Cited by 81 · see citing works
cDNA Cloning and Characterization of a Constitutively Expressed Isoform of the Human Peroxin Pex11p
Abe, I., & Fujiki, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9684 · Cited by 73 · see citing works
Mitochondrial division: New partners in membrane pinching
Yoon, Y., & McNiven, M. A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00011-2 · Cited by 69 · see citing works
Self-citationShin, H., Takatsu, H., Mukai, H., Munekata, E., Murakami, K., & Nakayama, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2780 · Cited by 67 · see citing works
Clofibrate‐inducible, 28‐kDa peroxisomal integral membrane protein is encoded by PEX11
Abe, I., Okumoto, K., Tamura, S., & Fujiki, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00815-1 · Cited by 65 · see citing works
Induction of tubular peroxisomes by UV irradiation and reactive oxygen species in HepG2 cells
Schrader, M., Wodopia, R., & Fahimi H., D. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700906 · Cited by 51 · see citing works
Self-citationTubular peroxisomes in HepG2 cells: Selective induction by growth factors and arachidonic acid
Schrader, M., Krieglstein, K., & Fahimi, H. D. (1998) · European Journal of Cell Biology · doi:10.1016/s0171-9335(98)80051-4 · Cited by 46 · see citing works
Self-citationCoordinated Development of β-Glucuronidase and β-Galactosidase in Mouse Organs
Meisler, M. H., & Paigen, K. (1972) · Science · doi:10.1126/science.177.4052.894 · Cited by 44 · see citing works
Organelle division: Self-assembling GTPases caught in the middle
Margolin, W. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00458-9 · Cited by 43 · see citing works
Three-Dimensional Ultrastructural Analysis of Peroxisomes in HepG2 Cells
Grabenbauer, M., Sätzler, K., Baumgart‐Vogt, E., et al. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:37 · Cited by 38 · see citing works
Self-citationBinding of coatomer by the PEX11 C‐terminus is not required for function
Maier, A. G., Schulreich, S., Bremser, M., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02132-3 · Cited by 22 · see citing works
Is dynamin a regular motor or a master regulator?
van der Bliek, A. M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01591-3 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Cook, T. A., Urrutia, R., and McNiven, M. A. (1994) Proc. Natl. Acad. Sci.
Cited by
Sorted by citations
Mitochondrial fusion and fission in cell life and death
Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · see citing works
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369 · see citing works
Mitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270 · see citing works
Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1907 · Cited by 1,066 · see citing works
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
Lee, Y.-J., Jeong, S.-Y., Karbowski, M., Smith, C. L., & Youle, R. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0294 · Cited by 1,042 · see citing works
Mitochondrial Dynamics in Mammalian Health and Disease
Liesa, M., Palacín, M., & Zorzano, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00030.2008 · Cited by 953 · see citing works
A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles
Sugiura, A., McLelland, G., Fon, E. A., & McBride, H. M. (2014) · The EMBO Journal · doi:10.15252/embj.201488104 · Cited by 862 · see citing works
Gandre-Babbe, S., & van der Bliek, A. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1287 · Cited by 769 · see citing works
A Lethal Defect of Mitochondrial and Peroxisomal Fission
Waterham, H. R., Koster, J., van Roermund, C. W. T., Mooyer, P. A. W., Wanders, R. J. A., & Leonard, J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064436 · Cited by 749 · see citing works
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works
The Peroxisome-Mitochondria Connection: How and Why?
Fransen, M., Lismont, C., & Walton, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061126 · Cited by 351 · see citing works
“DNM1L is a predominantly cytosolic large guanosine triphosphatase that, upon recruitment to organellar membranes, can self-oligomerize into helices, thereby catalyzing membrane fission and vesicle release in a GTP hydrolysis-dependent manner [50].”
BackgroundInfluentialCooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission
Osellame, L. D., Singh, A. P., Stroud, D. A., Palmer, C. S., Stojanovski, D., Ramachandran, R., & Ryan, M. T. (2016) · Journal of Cell Science · doi:10.1242/jcs.185165 · Cited by 336 · see citing works
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
Yamano, K., Fogel, A. I., Wang, C., van der Bliek, A. M., & Youle, R. J. (2014) · eLife · doi:10.7554/elife.01612 · Cited by 307 · see citing works
Palmer, C. S., Elgass, K. D., Parton, R. G., Osellame, L. D., Stojanovski, D., & Ryan, M. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479873 · Cited by 301 · see citing works
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells
Koch, A., Yoon, Y., Bonekamp, N. A., McNiven, M. A., & Schrader, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0159 · Cited by 308 · see citing works
The constriction and scission machineries involved in mitochondrial fission
Kraus, F., & Ryan, M. T. (2017) · Journal of Cell Science · doi:10.1242/jcs.199562 · Cited by 244 · see citing works
Fission and proliferation of peroxisomes
Schrader, M., Bonekamp, N. A., & Islinger, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.014 · Cited by 189 · see citing works
Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1
Bustillo-Zabalbeitia, I., Montessuit, S., Raemy, E., Basañez, G., Terrones, O., & Martinou, J.-C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102738 · Cited by 162 · see citing works
Organelle interplay-peroxisome interactions in health and disease.
Schrader, M., Kamoshita, M., & Islinger, M. (2020) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12083 · Cited by 149 · see citing works
Self-citationCivitarese, A. E., MacLean, P. S., Carling, S., Kerr-Bayles, L., McMillan, R. P., Pierce, A., Becker, T. C., Moro, C., Finlayson, J., Lefort, N., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.004 · Cited by 95 · see citing works
Functional multi-organelle units control inflammatory lipid metabolism of macrophages
Zimmermann, J. A., Lucht, K., Stecher, M., Badhan, C., Glaser, K. M., Epple, M. W., Koch, L. R., Deboutte, W., Manke, T., Ebnet, K., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01457-0 · Cited by 79 · see citing works
Self-Interaction of Human Pex11pβ during Peroxisomal Growth and Division
Bonekamp, N. A., Grille, S., Cardoso, M. J., Almeida, M., Aroso, M., Gomes, S., Magalhaes, A. C., Ribeiro, D., Islinger, M., & Schrader, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053424 · Cited by 29 · see citing works
Self-citationThe anti-viral dynamin family member MxB participates in mitochondrial integrity
Cao, H., Krueger, E. W., Chen, J., Drizyte-Miller, K., Schulz, M. E., & McNiven, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-14727-w · Cited by 25 · see citing works
Self-citation
- Authors
- Koch, A., Thiemann, M., Grabenbauer, M., Yoon, Y., McNiven, M. A., & Schrader, M.
- Affiliations
- Philipps University of Marburg (DE)
- Heidelberg University (DE)
- Max Planck Society (DE)
- Mayo Clinic (US)
- Corresponding author
- Schrader, Michael
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 278
- Issue
- 10
- Pages
- 8597-8605
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2065060753
- Cited by
- 374
- References
- 61
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 17 · 2023: 24 · 2022: 14 · 2021: 13 · 2020: 20 · 2019: 9 · 2018: 20 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 17 · 2013: 18 · 2012: 13
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Johns Hopkins University
- Philipps-Universität Marburg
- Universität Heidelberg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- peroxisome division, peroxisome proliferation, dominant-negative mutant, GTPase, bezafibrate, siRNA knockdown, HepG2 cells, rat liver
- MeSH terms
- Animals, Cell Line, Humans, Microscopy, Fluorescence, Microtubule-Associated Proteins, Proteins, Microscopy, Confocal, GTP Phosphohydrolases, Peroxisomes, Gene Silencing, Mitochondrial Proteins, Dynamins, RNA, Small Interfering, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
