The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
Open accessAbstract
Significance: The possibility that terminally differentiated hypertrophic chondrocytes could survive and become osteoblasts in vivo has been debated for more than a century. We show that hypertrophic chondrocytes can survive the cartilage-to-bone transition and become osteoblasts and osteocytes during endochondral bone formation and in bone repair. Our discovery provides the basis for a conceptual change of a chondrocyte-to-osteoblast lineage continuum, with new insights into the process of endochondral bone formation, the ontogeny of bone cells, and bone homeostasis. Furthermore, our findings have implications for current concepts on mechanisms of skeletal disorders and bone repair and regeneration.
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Cites
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570 · cited 2×
“Recent lineage studies failed to resolve this issue because non–HC-specific reagents were used to track the fate of HCs (2, 19, 20) or because the half-life of fluorescent protein tracers in HCs may not be sufficient to span a possible HC-to-osteoblast transition (21).”
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Cited by
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Bianco, P., & Robey, P. G. (2015) · Development · doi:10.1242/dev.102210 · Cited by 402
The Role of the Immune Cells in Fracture Healing
Baht, G. S., Vi, L., & Alman, B. A. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0423-2 · Cited by 275
Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood
Matic, I., Matthews, B. G., Wang, X., Dyment, N. A., Worthley, D. L., Rowe, D. W., Grcevic, D., & Kalajzic, I. (2016) · Stem Cells · doi:10.1002/stem.2474 · Cited by 195
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Komori, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122045 · Cited by 176
“Terminal hypertrophic chondrocytes gradually die by apoptosis or become osteoblasts, and the terminal hypertrophic chondrocyte layer is replaced with bone [10,11].”
Background
Metadata
- Authors
- Yang, L., Tsang, K. Y., Tang, H. C., Chan, D., & Cheah, K. S. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-04
- Volume
- 111
- Issue
- 33
- Pages
- 12097-12102
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072288858
- Cited by
- 760
- References
- 3
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- green
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