The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
Open accessAbstract
Significance: The possibility that terminally differentiated hypertrophic chondrocytes could survive and become osteoblasts in vivo has been debated for more than a century. We show that hypertrophic chondrocytes can survive the cartilage-to-bone transition and become osteoblasts and osteocytes during endochondral bone formation and in bone repair. Our discovery provides the basis for a conceptual change of a chondrocyte-to-osteoblast lineage continuum, with new insights into the process of endochondral bone formation, the ontogeny of bone cells, and bone homeostasis. Furthermore, our findings have implications for current concepts on mechanisms of skeletal disorders and bone repair and regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570 · cited 2×
“Recent lineage studies failed to resolve this issue because non–HC-specific reagents were used to track the fate of HCs (2, 19, 20) or because the half-life of fluorescent protein tracers in HCs may not be sufficient to span a possible HC-to-osteoblast transition (21).”
Background
Cited by
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Bianco, P., & Robey, P. G. (2015) · Development · doi:10.1242/dev.102210 · Cited by 402
The Role of the Immune Cells in Fracture Healing
Baht, G. S., Vi, L., & Alman, B. A. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0423-2 · Cited by 275
Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood
Matic, I., Matthews, B. G., Wang, X., Dyment, N. A., Worthley, D. L., Rowe, D. W., Grcevic, D., & Kalajzic, I. (2016) · Stem Cells · doi:10.1002/stem.2474 · Cited by 195
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Komori, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122045 · Cited by 176
“Terminal hypertrophic chondrocytes gradually die by apoptosis or become osteoblasts, and the terminal hypertrophic chondrocyte layer is replaced with bone [10,11].”
BackgroundThe Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation
Li, J., & Dong, S. (2016) · Stem Cells International · doi:10.1155/2016/2470351 · Cited by 170
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss
Delaisse, J.-M., Andersen, T. L., Kristensen, H. B., Jensen, P. R., Andreasen, C. M., & Søe, K. (2020) · Bone · doi:10.1016/j.bone.2020.115628 · Cited by 152
The role of hedgehog signalling in skeletal health and disease
Alman, B. A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.84 · Cited by 141
The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.008 · Cited by 96
Tan, Z., Kong, M., Wen, S., Tsang, K. Y., Niu, B., Hartmann, C., Chan, D., Hui, C.-C., & Cheah, K. S. E. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4132 · Cited by 52
Self-citationMaresin 1 resolves aged‐associated macrophage inflammation to improve bone regeneration
Huang, R., Vi, L., Zong, X., & Baht, G. S. (2020) · The FASEB Journal · doi:10.1096/fj.202001145r · Cited by 47
Aman, A. J., Saunders, L. M., Carr, A. A., Srivatasan, S., Eberhard, C., Carrington, B., Watkins-Chow, D., Pavan, W. J., Trapnell, C., & Parichy, D. M. (2023) · eLife · doi:10.7554/elife.86670 · Cited by 30
Molecular Mechanisms Involved in Craniosynostosis
YAPIJAKIS, C., PACHIS, N., SOTIRIADOU, T., VAILA, C., MICHOPOULOU, V., & VASSILIOU, S. (2023) · In Vivo · doi:10.21873/invivo.13052 · Cited by 28
Zhang, X., Deng, H., Shen, H., & Ehrlich, M. (2021) · JBMR Plus · doi:10.1002/jbm4.10481 · Cited by 20
Metadata
- Authors
- Yang, L., Tsang, K. Y., Tang, H. C., Chan, D., & Cheah, K. S. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-04
- Volume
- 111
- Issue
- 33
- Pages
- 12097-12102
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072288858
- Cited by
- 760
- References
- 3
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
