Cited by 402Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationBone Metabolism and Diseases

Skeletal stem cells

Open access
Bianco, Paolo, Robey, Pamela G.·2015·Development

Abstract

Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow organ. SSCs conjoin skeletal and hematopoietic physiology, and are a tool for understanding and ameliorating skeletal and hematopoietic disorders. Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored.

Integrity signals

Registry

Crossref · 10.1242/dev.102210

Cites

142 of 142 references verified0 citation errors · 0 not checkable

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  • Bone marrow stroma contains self-renewing, multipotent progenitors that can give rise to osteoblasts, ensuring a reservoir of bone-forming cells for bone growth, modeling and remodeling.

    “The bone marrow stroma contains self-renewing, multipotent progenitors that can give rise to osteoblasts, thus ensuring a reservoir of bone-forming cells for bone growth, modeling and remodeling.273”

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Authors
Bianco, P., & Robey, P. G.
Affiliations
  • Sapienza University of Rome (IT)
  • National Institutes of Health (US)
Venue
Development
Published
2015-03-15
Volume
142
Issue
6
Pages
1023-1027
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2116104054
Cited by
402
References
142
Citations by year
2026: 24 · 2025: 26 · 2024: 28 · 2023: 37 · 2022: 37 · 2021: 35 · 2020: 45 · 2019: 34 · 2018: 34 · 2017: 29 · 2016: 32 · 2015: 6 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
4.67
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
skeletal stem cells, bone marrow, hematopoietic stroma, skeletal development, chondrogenesis, hematopoiesis, postnatal growth, bone disease, hematopoietic disorders
MeSH terms
Bone and Bones, Cartilage, Humans, Terminology as Topic, Adipocytes, Cell Lineage, Multipotent Stem Cells, Stem Cell Niche, Mesenchymal Stem Cells

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