Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

MatInspector and beyond: promoter analysis based on transcription factor binding sites

Cartharius, K., Frech, K., Grote, K., Klocke, B., Haltmeier, M., Klingenhoff, A., Frisch, M., Bayerlein, M., & Werner, T. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti473 · Cited by 1,962 · see citing works

Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis

Lecuit, T., & Lenne, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2222 · Cited by 1,278 · see citing works

α-Catenin as a tension transducer that induces adherens junction development

Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A., & Shibata, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2055 · Cited by 972 · see citing works

The creatine kinase system and pleiotropic effects of creatine

Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011) · Amino Acids · doi:10.1007/s00726-011-0877-3 · Cited by 797 · see citing works

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682 · see citing works

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works

Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border

Mooseker, M. S. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.001233 · Cited by 527 · see citing works

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502 · see citing works

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496 · see citing works

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461 · see citing works

Direct antioxidant properties of creatine

Lawler, J. M., Barnes, W. S., Wu, G., Song, W., & Demaree, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6164 · Cited by 448 · see citing works

Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

Ivanov, A. I., Parkos, C. A., & Nusrat, A. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100168 · Cited by 366 · see citing works

Proteome analysis of human colon cancer by two‐dimensional difference gel electrophoresis and mass spectrometry

Friedman, D. B., Hill, S., Keller, J. W., Merchant, N. B., Levy, S., Coffey, R. J., & Caprioli, R. M. (2004) · PROTEOMICS · doi:10.1002/pmic.200300635 · Cited by 357 · see citing works

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

Smutny, M., Cox, H. L., Leerberg, J. M., Kovács, É., Conti, M. A., Ferguson, C., Hamilton, N., Parton, R. G., Adelstein, R. S., & Yap, A. S. (2010) · Nature Cell Biology · doi:10.1038/ncb2072 · Cited by 332 · see citing works

Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease

Söderholm, J. D., Olaison, G., Peterson, K. H., Franzén, L. E., Lindmark, T., Wirén, M., Tagesson, C., & Sjödahl, R. (2002) · Gut · doi:10.1136/gut.50.3.307 · Cited by 290 · see citing works

HIF-1 and HIF-2: working alone or together in hypoxia?

Ratcliffe, P. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31750 · Cited by 284 · see citing works

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

Marchiando, A. M., Shen, L., Graham, W. V., Edelblum, K. L., Duckworth, C. A., Guan, Y., Montrose, M. H., Turner, J. R., & Watson, A. J. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.004 · Cited by 276 · see citing works

Differential Roles for Actin Polymerization and a Myosin II Motor in Assembly of the Epithelial Apical Junctional Complex

Ivanov, A. I., Hunt, D. A., Utech, M., Nusrat, A., & Parkos, C. A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0043 · Cited by 232 · see citing works

Mitochondrial Creatine Kinase Activity Prevents Reactive Oxygen Species Generation

Meyer, L. E., Machado, L. B., Santiago, A. P. S. A., da‐Silva, W. S., Felice, F. G. D., Holub, O., de Oliveira, M. F., & Galina, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604123200 · Cited by 210 · see citing works

Hypoxia inducible factor 1α and 2α overexpression in inflammatory bowel disease

Giatromanolaki, A. N., Sivridis, E., Maltezos, E., Papazoglou, D., Simopoulos, C., Gatter, K. C., Harris, A. L., & Koukourakis, M. I. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.3.209 · Cited by 209 · see citing works

Role for Actin Filament Turnover and a Myosin II Motor in Cytoskeleton-driven Disassembly of the Epithelial Apical Junctional Complex

Ivanov, A. I., McCall, I. C., Parkos, C. A., & Nusrat, A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-02-0163 · Cited by 206 · see citing works

A Unique Role for Nonmuscle Myosin Heavy Chain IIA in Regulation of Epithelial Apical Junctions

Ivanov, A. I., Bachar, M., Babbin, B. A., Adelstein, R. S., Nusrat, A., & Parkos, C. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000658 · Cited by 178 · see citing works

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

Xue, X., Ramakrishnan, S. K., Anderson, E. R., Taylor, M. J., Zimmermann, E. M., Spence, J. R., Huang, S., Greenson, J. K., & Shah, Y. M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.010 · Cited by 171 · see citing works

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

Shah, Y. M., Ito, S., Morimura, K., Chen, C., Yim, S., Haase, V. H., & Gonzalez, F. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.009 · Cited by 168 · see citing works

Mechanism of brush border contractility studied by the quick-freeze, deep-etch method.

Hirokawa, N., Keller, T. C. S., Chasan, R., & Mooseker, M. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.5.1325 · Cited by 149 · see citing works

Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis

Glover, L. E., & Colgan, S. P. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.056 · Cited by 124 · see citing works

Flow of energy in the outer retina in darkness and in light

Linton, J. D., Holzhausen, L. C., Babai, N. Z., Song, H., Miyagishima, K. J., Stearns, G., Lindsay, K. J., Wei, J., Chertov, A. O., Peters, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002471107 · Cited by 119 · see citing works

Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease

Schürmann, G., Brüwer, M., Klotz, A., Schmid, K. W., Senninger, N. J., & Zimmer, K. ‐. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050181 · Cited by 110 · see citing works

Dynamic Regulation of Epithelial Cell Fate and Barrier Function by Intercellular Junctions

Koch, S., & Nusrat, A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04025.x · Cited by 89 · see citing works

Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer

Balasubramani, M., Day, B. W., Schoen, R. E., & Getzenberg, R. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3771 · Cited by 87 · see citing works

Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease

Lin, Y., Chen, C., Soong, B., Wu, Y., Chen, H., Yeh, W.-Y., Wu, D.-R., Lin, Y., Poon, P. W. F., Cheng, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43220 · Cited by 44 · see citing works

Creatine kinase brain overexpression protects colorectal cells from various metabolic and non‐metabolic stresses

Mooney, S. M., Rajagopalan, K., Williams, B. H., Zeng, Y., Christudass, C. S., Li, Y., Yin, B., Kulkarni, P., & Getzenberg, R. H. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23020 · Cited by 44 · see citing works

Discrete subcellular localization of a cytoplasmic and a mitochondrial isozyme of creatine kinase in intestinal epithelial cells

Keller, T. C. S., & Gordon, P. V. (1991) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970190305 · Cited by 27 · see citing works

Functional coupling to brush border creatine kinase imparts a selective energetic advantage to contractile ring myosin in intestinal epithelial cells

Gordon, P. V., & Keller, T. C. S. (1992) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970210105 · Cited by 16 · see citing works

Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function

Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works

HIF1α and metabolic reprogramming in inflammation

Corcoran, S. E., & O'Neill, L. A. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84431 · Cited by 789 · see citing works

Pathway paradigms revealed from the genetics of inflammatory bowel disease

Graham, D. B., & Xavier, R. J. (2020) · Nature · doi:10.1038/s41586-020-2025-2 · Cited by 769 · see citing works

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

Zheng, L., Kelly, C. J., & Colgan, S. P. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2015 · Cited by 488 · see citing works

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Singhal, R., & Shah, Y. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011188 · Cited by 379 · see citing works

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Eltzschig, H. K., Bratton, D. L., & Colgan, S. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4422 · Cited by 363 · see citing works

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364 · see citing works

Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans

Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329 · see citing works

T cell metabolic fitness in antitumor immunity

Siska, P. J., & Rathmell, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.007 · Cited by 315 · see citing works

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021637 · Cited by 288 · see citing works

Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction

Shao, T., Zhao, C., Li, F., Gu, Z., Liu, L., Zhang, L., Wang, Y., He, L., Liu, Y., Liu, Q., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.05.021 · Cited by 258 · see citing works

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

Ji, L., Zhao, X., Zhang, B., Kang, L., Song, W., Zhao, B., Xie, W., Chen, L., & Hu, X. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.007 · Cited by 238 · see citing works

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

Saeedi, B. J., Kao, D. J., Kitzenberg, D., Dobrinskikh, E., Schwisow, K. D., Masterson, J. C., Kendrick, A. A., Kelly, C. J., Bayless, A. J., Kominsky, D. J., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1194 · Cited by 231 · see citing works

The role of dietary creatine

Brosnan, M. E., & Brosnan, J. T. (2016) · Amino Acids · doi:10.1007/s00726-016-2188-1 · Cited by 185 · see citing works

Oxygen metabolism and barrier regulation in the intestinal mucosa

Glover, L. E., Lee, J. S., & Colgan, S. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84429 · Cited by 172 · see citing works

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4412 · Cited by 161 · see citing works

Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function

Lee, J. S., Wang, R. X., Alexeev, E. E., Lanis, J. M., Battista, K. D., Glover, L. E., & Colgan, S. P. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000269 · Cited by 149 · see citing works

Mechanisms of Pediatric Inflammatory Bowel Disease

Peloquin, J. M., Goel, G., Villablanca, E. J., & Xavier, R. J. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112151 · Cited by 138 · see citing works

Hypoxia and Mucosal Inflammation

Colgan, S. P., Campbell, E. L., & Kominsky, D. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044231 · Cited by 133 · see citing works

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

Welden, S. V., Selfridge, A. C., & Hindryckx, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.101 · Cited by 124 · see citing works

E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

Daulagala, A. C., Bridges, C., & Kourtidis, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112756 · Cited by 119 · see citing works

Ruffles and spikes: Control of tight junction morphology and permeability by claudins

Lynn, K. S., Peterson, R. J., & Koval, M. H. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183339 · Cited by 112 · see citing works

Hypoxia: molecular pathophysiological mechanisms in human diseases

Rocca, Y. D., Fonticoli, L., Rajan, T. S., Trubiani, O., Caputi, S., Diomede, F., Pizzicannella, J., & Marconi, G. D. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00912-6 · Cited by 109 · see citing works

Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease

Mehta, S. J., Nijhuis, A. M., Kumagai, T., Lindsay, J. O., & Silver, A. R. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1994-6 · Cited by 105 · see citing works

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis

Cunningham, K. E., Vincent, G., Sodhi, C. P., Novak, E. A., Ranganathan, S., Egan, C. E., Stolz, D. B., Rogers, M. B., Firek, B., Morowitz, M. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.688812 · Cited by 99 · see citing works

Role of Intestinal HIF-2α in Health and Disease

Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 98 · see citing works

Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function

Hall, C. H. T., Lee, J. S., Murphy, E. M., Gerich, M. E., Dran, R. J., Glover, L. E., Abdulla, Z. I., Skelton, M. R., & Colgan, S. P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.033 · Cited by 90 · see citing works

Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients

Wallimann, T., Riek, U., & Möddel, M. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2016.12.002 · Cited by 87 · see citing works

Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity

Guerbette, T., Boudry, G., & Lan, A. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101546 · Cited by 91 · see citing works

The role of hypoxia in intestinal inflammation

Shah, Y. M. (2016) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0030-1 · Cited by 85 · see citing works

Hypoxia and inflammatory bowel disease

Cummins, E. P., & Crean, D. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.09.004 · Cited by 83 · see citing works

Creatine maintains intestinal homeostasis and protects against colitis

Turer, E. E., McAlpine, W., Wang, K.-W., Lu, T., Li, X., Tang, M., Zhan, X., Wang, T., Zhan, X., Bu, C.-H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621400114 · Cited by 76 · see citing works

Creatine kinase in ischemic and inflammatory disorders

Kitzenberg, D., Colgan, S. P., & Glover, L. E. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0114-5 · Cited by 76 · see citing works

Stabilization of HIF through inhibition of Cullin‐2 neddylation is protective in mucosal inflammatory responses

Curtis, V. F., Ehrentraut, S., Campbell, E. L., Glover, L. E., Bayless, A., Kelly, C. J., Kominsky, D. J., & Colgan, S. P. (2014) · The FASEB Journal · doi:10.1096/fj.14-259663 · Cited by 69 · see citing works

Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation

Xie, L., Xue, X., Taylor, M. J., Ramakrishnan, S. K., Nagaoka, K., Hao, C., Gonzalez, F. J., & Shah, Y. M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00324-14 · Cited by 69 · see citing works

Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function

Ornelas, A., Dowdell, A. S., Lee, J. S., & Colgan, S. P. (2022) · Cells · doi:10.3390/cells11060944 · Cited by 64 · see citing works

The Hypoxia–Adenosine Link during Intestinal Inflammation

Bowser, J. L., Phan, L. H., & Eltzschig, H. K. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701414 · Cited by 61 · see citing works

Metabolic Host–Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD)

Dowdell, A. S., & Colgan, S. P. (2021) · Pharmaceuticals · doi:10.3390/ph14080708 · Cited by 55 · see citing works

Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways

Qi, L., Fu, Q., Du, C., Wu, D., GUOQIAN, Z., BO, Y., & LINA, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1965 · Cited by 56 · see citing works

Oral vitamin B 12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice

Kelly, C. J., Alexeev, E. E., Farb, L., Vickery, T. W., Zheng, L., Campbell, E. L., Kitzenberg, D., Battista, K. D., Kominsky, D. J., Robertson, C. E., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1597667 · Cited by 54 · see citing works

Metabolic regulation of intestinal epithelial barrier during inflammation

Colgan, S. P., Curtis, V. F., Lanis, J. M., & Glover, L. E. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.970936 · Cited by 49 · see citing works

Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities

Meier, K. H. U., Trouillon, J., Li, H., Lang, M., Fuhrer, T., Zamboni, N., Sunagawa, S., Macpherson, A. J., & Sauer, U. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00802-1 · Cited by 48 · see citing works

Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial

Wallimann, T., Hall, C. H. T., Colgan, S. P., & Glover, L. E. (2021) · Nutrients · doi:10.3390/nu13051429 · Cited by 50 · see citing works

Epithelial Barrier Regulation by Hypoxia-Inducible Factor

Glover, L. E., & Colgan, S. P. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201608-610mg · Cited by 43 · see citing works

Human colon function ex vivo: Dependence on oxygen and sensitivity to antibiotic

Schwerdtfeger, L., Nealon, N. J., Ryan, E. P., & Tobet, S. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217170 · Cited by 44 · see citing works

Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis

Steiner, C. A., Cartwright, I. M., Taylor, C. T., & Colgan, S. P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00227.2022 · Cited by 42 · see citing works

Hypoxia‐sensitive pathways in intestinal inflammation

Brown, E., & Taylor, C. T. (2017) · The Journal of Physiology · doi:10.1113/jp274350 · Cited by 40 · see citing works

The Potential Role of Creatine in Vascular Health

Clarke, H. E., Hickner, R. C., & Ormsbee, M. J. (2021) · Nutrients · doi:10.3390/nu13030857 · Cited by 43 · see citing works

Influences of dietary Eucommia ulmoides leaf extract on the hepatic lipid metabolism, inflammation response, intestinal antioxidant capacity, intestinal microbiota, and disease resistance of the channel catfish (Ictalurus punctatus)

Zhang, F., Hao, Q., Zhang, Q.-S., Lv, H., Yang, Y., Chaoran, Zhang, Z., & Zhou, Z. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.02.053 · Cited by 39 · see citing works

Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn’s disease

Zhang, S., Morgan, X. C., Dogan, B., Martin, F., Strickler, S., Oka, A., Herzog, J., Liu, B., Dowd, S. E., Huttenhower, C., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.157013 · Cited by 36 · see citing works

Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic

Lee, J. S., Wang, R. X., Alexeev, E. E., & Colgan, S. P. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1880241 · Cited by 37 · see citing works

Beyond mitochondria: Alternative energy-producing pathways from all strata of life

Auger, C., Vinaik, R., Appanna, V. D., & Jeschke, M. G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154733 · Cited by 36 · see citing works

Low-protein diets supplemented with glutamic acid or aspartic acid ameliorate intestinal damage in weaned piglets challenged with hydrogen peroxide

Chen, S., Wu, X., Duan, J., Huang, P., Li, T., Yin, Y., & Yin, J. (2021) · Animal nutrition · doi:10.1016/j.aninu.2020.12.005 · Cited by 35 · see citing works

CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation

Wang, Z., Hulsurkar, M. M., Zhuo, L., Xu, J., Yang, H., Naderinezhad, S., Wang, L., Zhang, G., Ai, N., Li, L., et al. (2021) · Neoplasia · doi:10.1016/j.neo.2021.09.005 · Cited by 33 · see citing works

Creatine: a miserable life without it

Wallimann, T., & Harris, R. C. (2016) · Amino Acids · doi:10.1007/s00726-016-2297-x · Cited by 34 · see citing works

Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids

Walaas, G. A., Gopalakrishnan, S., Bakke, I., Skovdahl, H. K., Flatberg, A., Østvik, A. E., Sandvik, A. K., & Bruland, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1095812 · Cited by 33 · see citing works

Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression

Kang, I., Kondo, D. G., Kim, J., Lyoo, I. K., Yurgelun-Todd, D. A., Hwang, J., & Renshaw, P. F. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110398 · Cited by 30 · see citing works

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2

Chen, L., Qi, Q., Jiang, X., Wu, J., Li, Y., Liu, Z., Cai, Y., Ran, H., Zhang, S., Zhang, C., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1348 · Cited by 30 · see citing works

A study of the potential effect of dietary fishmeal replacement with cricket meal (Gryllus bimaculatus) on growth performance, blood health, liver antioxidant activities, intestinal microbiota and immune-related gene expression of juvenile channel catfish

Fan, K., Liu, H., Pei, Z., Brown, P. B., & Huang, Y. (2022) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2022.115542 · Cited by 30 · see citing works

Tissue metabolism and host-microbial interactions in the intestinal mucosa

Chun, C. L., Zheng, L., & Colgan, S. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.027 · Cited by 30 · see citing works

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

Xiao, J., Guo, X., & Wang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385907 · Cited by 29 · see citing works

Physiologic hypoxia in the intestinal mucosa: a central role for short-chain fatty acids

Wang, T., Wang, R. X., & Colgan, S. P. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00472.2024 · Cited by 28 · see citing works

Metabolism-Guided Bowel Resection

Diana, M., Noll, É., Diemunsch, P. A., Moussallieh, F., Namer, I. J., Charles, A., Lindner, V., Agnus, V., Gény, B., & Marescaux, J. (2015) · Surgical Innovation · doi:10.1177/1553350615598620 · Cited by 29 · see citing works

Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives

Casciola, R., Leoni, L., Cuffari, B., Pecchini, M., Menozzi, R., Colecchia, A., & Ravaioli, F. (2023) · Nutrients · doi:10.3390/nu15040863 · Cited by 35 · see citing works

3D chitosan scaffolds support expansion of human neural stem cells in chemically defined condition

Chang, F., James, M. M., Qassab, A. M., Zhou, Y., Ando, Y., Shi, M., & Zhang, M. (2023) · Matter · doi:10.1016/j.matt.2023.08.014 · Cited by 28 · see citing works

Determinants of hypoxia-inducible factor activity in the intestinal mucosa

Fagundes, R. R., & Taylor, C. T. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00203.2017 · Cited by 24 · see citing works

Pre-activation of TLR3 enhances the therapeutic effect of BMMSCs through regulation the intestinal HIF-2α signaling pathway and balance of NKB cells in experimental alcoholic liver injury

Ge, L.-C., Chen, D., Chen, W., Cai, C., Tao, Y., Ye, S., Lin, Z., Wang, X., Li, J., Xu, L., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.021 · Cited by 24 · see citing works

Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis

Solanki, S. A., Devenport, S. N., Ramakrishnan, S. K., & Shah, Y. M. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00081.2019 · Cited by 23 · see citing works

CKMT1 deficiency contributes to mitochondrial dysfunction and promotes intestinal epithelial cell apoptosis via reverse electron transfer-derived ROS in colitis

Wang, Z., Wu, H., Chang, X., Song, Y., Chen, Y., Yan, Z., Gu, L., Pang, R., Xia, T., He, Z., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07504-4 · Cited by 23 · see citing works

PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα

Brown, E. L., Snow, R. J., Wright, C. R., Cho, Y., Wallace, M. A., Kralli, A., & Russell, A. P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.08.010 · Cited by 24 · see citing works

Revisiting the “starved gut” hypothesis in inflammatory bowel disease

Colgan, S. P., Wang, R. X., Hall, C. H. T., Bhagavatula, G., & Lee, J. S. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000016 · Cited by 23 · see citing works

Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn’s Disease

Guo, C., & Shen, J. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08795-5 · Cited by 23 · see citing works

Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers

Ornelas, A., Welch, N. M., Countess, J. A., Zhou, L., Wang, R. X., Dowdell, A. S., & Colgan, S. P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2267706 · Cited by 22 · see citing works

Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†

Simintiras, C. A., Sánchez, J. M., McDonald, M., O’Callaghan, E., Aburima, A. A., & Lonergan, P. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab021 · Cited by 21 · see citing works

Sulforaphane attenuates 5-fluorouracil induced intestinal injury in mice

Wei, L., Wang, J., Yan, L., Shui, S., Wang, L., Zheng, W., Liu, S., Liu, C., & Zheng, L. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103965 · Cited by 21 · see citing works

Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis

Wang, S., Tao, P., Hu, H., Yuan, J., Zhao, L., Sun, B., Zhang, W.-J., & Lin, J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i47.8308 · Cited by 20 · see citing works

Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling

Curtis, V. F., Cartwright, I. M., Lee, J. S., Wang, R. X., Kao, D. J., Lanis, J. M., Burney, K. M., Welch, N. M., Hall, C. H. T., Goldberg, M. S., et al. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-06-0377 · Cited by 20 · see citing works

HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

Czopik, A. K., McNamee, E. N., Vaughn, V., Huang, X., Bang, I. H., Clark, T., Wang, Y., Ruan, W., Nguyen, T. T., Masterson, J. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52113-y · Cited by 19 · see citing works

The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester

Ellery, S. J., Murthi, P., Gatta, P. A. D., May, A. K., Davies-Tuck, M. L., Kowalski, G. M., Callahan, D. L., Bruce, C. R., Wallace, E. M., Walker, D. W., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030806 · Cited by 22 · see citing works

Effects of dietary supplementation of guanidino acetic acid on growth performance, thigh meat quality and development of small intestine in Partridge-Shank broilers

Ren, Q. C., Xuan, J., Yan, X. C., Hu, Z., & Wang, F. (2018) · The Journal of Agricultural Science · doi:10.1017/s0021859618001156 · Cited by 18 · see citing works

Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation

Liu, A., Huang, M., Xi, Y., Deng, X., & Xu, K. (2025) · Biomedicines · doi:10.3390/biomedicines13061422 · Cited by 17 · see citing works

Cerebral bioenergetic differences measured by phosphorus‐31 magnetic resonance spectroscopy between bipolar disorder and healthy subjects living in two different regions suggesting possible effects of altitude

Hwang, J., DeLisi, L., Öngür, D., Riley, C., Zuo, C., Shi, X.-F., Sung, Y., Kondo, D., Kim, T.-S., Villafuerte, R., et al. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12893 · Cited by 16 · see citing works

Cold-inducible RNA-binding protein maintains intestinal barrier during deep hypothermic circulatory arrest

Li, Y., Liu, M., Gao, S., Cai, L., Zhang, Q., Yan, S., Liu, G., & Ji, B. (2019) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivz147 · Cited by 16 · see citing works

Gut vascular barrier in the pathogenesis and resolution of Crohn's disease: A novel link from origination to therapy

Jingjie, W., & Shen, J. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109683 · Cited by 16 · see citing works

Fuzi lizhong pills alter microbial community compositions and metabolite profiles in ulcerative colitis rat with spleen-kidney yang deficiency syndrome

Zhou, Y.-L., Wu, J., Wang, H., Feng, W., Peng, F., Zhang, R., Yan, H.-L., Liu, J., Tan, Y., & Peng, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118645 · Cited by 16 · see citing works

A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression

Onyiah, J. C., Schaefer, R. E. M., & Colgan, S. P. (2018) · Journal of Innate Immunity · doi:10.1159/000488914 · Cited by 16 · see citing works

Creatine metabolism in the uterus: potential implications for reproductive biology

Philip, M., Snow, R. J., Gatta, P. A. D., Bellofiore, N., & Ellery, S. J. (2020) · Amino Acids · doi:10.1007/s00726-020-02896-3 · Cited by 16 · see citing works

The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

Foresto‐Neto, O., da Silva, A. R. P. A., Cipelli, M., Santana, F. P. R., & Câmara, N. O. S. (2023) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.23.012 · Cited by 15 · see citing works

Evaluation of the effect of Dahuang–Mudan decoction on TNBS‐induced colitis using UPLC–QTOF/MS‐based metabolomic analysis

Nong, F., Luo, S., Liang, Y., Zhao, Z., Xing, S., Wen, B., & Zhou, L. (2020) · Biomedical Chromatography · doi:10.1002/bmc.5003 · Cited by 15 · see citing works

Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia

Martínez-Ruiz, M., Robeson, M. S., & Piccolo, B. D. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2507701 · Cited by 15 · see citing works

Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination

Dowdell, A. S., Cartwright, I. M., Kitzenberg, D., Kostelecky, R. E., Mahjoob, O., Saeedi, B. J., Welch, N., Glover, L. E., & Colgan, S. P. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111409 · Cited by 14 · see citing works

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease

Lun, J., Zhang, H., Guo, J., Yu, M., & Fang, J. S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1045997 · Cited by 14 · see citing works

Research Progress on the Mechanism of Intestinal Barrier Damage and Drug Therapy in a High Altitude Environment

Cheng, J., Sun, Y., Zhao, Y., Guo, Q., Wang, Z., & Wang, R. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230309090241 · Cited by 13 · see citing works

Modifying microbially derived short chain fatty acids to promote health

Ornelas, A., Countess, J. A., Kim, J. Y., & Colgan, S. P. (2025) · The Journal of Physiology · doi:10.1113/jp287585 · Cited by 13 · see citing works

Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease

Galkin, F., Pulous, F. E., Fu, Y., Zhang, M., Pun, F. W., Ren, F., & Zhavoronkov, A. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102551 · Cited by 13 · see citing works

Oxygen metabolism and innate immune responses in the gut

Colgan, S. P., & Campbell, E. L. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00113.2017 · Cited by 12 · see citing works

Hypoxic Functional Regulation Pathways in the GI Tract: Focus on the HIF-1α and Microbiota’s Crosstalk

Mattia, M. D., Sallese, M., Neri, M., & Lopetuso, L. R. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae046 · Cited by 11 · see citing works

A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress

Katz, J. L., Geng, Y., Billingham, L. K., Sadagopan, N. S., DeLay, S. L., Subbiah, J., Chia, T.-Y., McManus, G., Wei, C., Wang, H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-73051-1 · Cited by 11 · see citing works

Fundamental Role for HIF‐2‐regulated Creatine Kinase Pathway in Epithelial Apical Junctional Integrity

Glover, L. E., Saeedi, B. J., Ehrentraut, S., Campbell, E. L., Kelly, C. J., Kominsky, D. J., & Colgan, S. P. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.256.5

Creatine Kinase, a Novel HIF-2a Target, Regulates Apical Junction Complex Assembly in Intestinal Epithelial Cells

Glover, L. E., Bowers, B., Saeedi, B. J., Ehrentraut, S., Kominsky, D. J., Campbell, E. L., Kelly, C. J., & Colgan, S. P. (2012) · Inflammatory Bowel Diseases · doi:10.1097/00054725-201212001-00254

Contributions of Creatine Kinase to Mucosal Immune Responses in Colitis

Lanis, J. M., Lee, J. S., Cartwright, I. M., Hall, C. H., & Colgan, S. P. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.05630

Metabolic regulation of intestinal epithelial barrier during inflammation

Colgan, S. P., Curtis, V. F., Lanis, J. M., & Glover, L. E. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.970936 · Cited by 49 · see citing works

Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis

Bhagavatula, G., Worledge, C. S., Schaepe, C., Murphy, E. M., Neuhart, R. M., Lee, J. S., Cartwright, I. M., Colgan, S. P., & Hall, C. H. T. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101557 · Cited by 5 · see citing works