Cited by 155Inflammatory Bowel DiseaseCancer, Hypoxia, and MetabolismDigestive system and related health

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Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

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Glover, Louise E., Bowers, Brittelle E., Saeedi, Bejan, Ehrentraut, Stefan F., Campbell, Eric L., Bayless, Amanda J., Dobrinskikh, Evgenia, Kendrick, Agnieszka A., Kelly, Caleb J., Burgess, Adrianne, Miller, Lauren, Kominsky, Douglas J., Jedlicka, Paul, Colgan, Sean P.·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1302840110PMC PMC3856803

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Abstract

Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpressed in mucosal epithelia that constitute the barrier between the lumen and the underlying immune milieu, we sought to define the discrete contribution of HIF-1 and HIF-2 transactivation pathways to intestinal epithelial cell homeostasis. The present study identifies creatine kinases (CKs), key metabolic enzymes for rapid ATP generation via the phosphocreatine-creatine kinase (PCr/CK) system, as a unique gene family that is coordinately regulated by HIF. Cytosolic CKs are expressed in a HIF-2-dependent manner in vitro and localize to apical intestinal epithelial cell adherens junctions, where they are critical for junction assembly and epithelial integrity. Supplementation with dietary creatine markedly ameliorated both disease severity and inflammatory responses in colitis models. Further, enzymes of the PCr/CK metabolic shuttle demonstrate dysregulated mucosal expression in a subset of ulcerative colitis and Crohn disease patients. These findings establish a role for HIF-regulated CK in epithelial homeostasis and reveal a fundamental link between cellular bioenergetics and mucosal barrier.

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Authors: Glover, L. E., Bowers, B. E., Saeedi, B., Ehrentraut, S. F., Campbell, E. L., Bayless, A. J., Dobrinskikh, E., Kendrick, A. A., Kelly, C. J., Burgess, A., Miller, L., Kominsky, D. J., Jedlicka, P., & Colgan, S. P.
Affiliations: University of Colorado Anschutz (US)
Mucosal Inflammation Program,
Department of Medicine,
ORCID: Glover, Louise E.
Saeedi, Bejan
Ehrentraut, Stefan F.
Campbell, Eric L.
Dobrinskikh, Evgenia
Kendrick, Agnieszka A.
Kelly, Caleb J.
Jedlicka, Paul
Colgan, Sean P.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-11-18
Volume: 110
Issue: 49
Pages: 19820-19825
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1302840110
PMC: PMC3856803
OpenAlex: W2066159720
Cited by: 155
References: 37
Citations by year: 2026: 11 · 2025: 19 · 2024: 12 · 2023: 17 · 2022: 14 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 8 · 2014: 7
FWCI: 6.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL060569, HL-60569)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK050189, DK095491, R37DK050189, R29DK050189, DK-50189, R01DK095491)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Keywords: creatine kinase, hypoxia-inducible factor, HIF-1α, HIF-2α, colitis, intestinal epithelial barrier, adherens junctions, ulcerative colitis, Crohn's disease, hypoxia, bioenergetics, mucosal inflammation
MeSH terms: Analysis of Variance, Chromatography, High Pressure Liquid, Colitis, Creatine, Creatine Kinase, Flow Cytometry, Fluorescent Antibody Technique, Humans, Blotting, Western, Signal Transduction, Cell Hypoxia, Gene Expression Regulation, Enzymologic, Polymerase Chain Reaction, DNA Primers, Immunoprecipitation, Aryl Hydrocarbon Receptor Nuclear Translocator, Gene Knockdown Techniques

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Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

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