Cited by 589Circadian rhythm and melatoninTreatment of Major DepressionSleep and Wakefulness Research

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Open access

Li, Jun Z., Bunney, Blynn G., Meng, Fan, Hagenauer, Megan H., Walsh, David M., Vawter, Marquis P., Evans, Simon J., Choudary, Prabhakara V., Cartagena, Preston, Barchas, Jack D., Schatzberg, Alan F., Jones, Edward G., Myers, Richard M., Watson, Stanley J., Akil, Huda, Bunney, William E.·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1305814110PMC PMC3683716

Open this paper in CoChat — free account

Abstract

A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain were difficult to characterize. Here, we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-h cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses (“controls”) and 34 patients with MDD. Our dataset covered ∼12,000 transcripts in the dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, and cerebellum. Several hundred transcripts in each region showed 24-h cyclic patterns in controls, and >100 transcripts exhibited consistent rhythmicity and phase synchrony across regions. Among the top-ranked rhythmic genes were the canonical clock genes BMAL1(ARNTL), PER1-2-3, NR1D1(REV-ERBa), DBP, BHLHE40 (DEC1) , and BHLHE41(DEC2) . The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in the brains of patients with MDD due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggests potentially important molecular targets for treatment of mood disorders.

Integrity signals

Registry

Crossref · 10.1073/pnas.1305814110

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 2×
“This artifact is analogous to the phenomenon of population stratification in genetic association studies; thus, we adopted a correction method similar to the genomic control method (17).”
BackgroundMethod
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
KEGG for representation and analysis of molecular networks involving diseases and drugs
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., & Hirakawa, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp896 · Cited by 2,322
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

Show all 59 references

Sorted by citations

Items 401–500 of 587

Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease
Lim, A. S. P. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00017-0 · Cited by 6
The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders
Zhdanova, I. V., Rogers, J., González‐Martínez, J., & Farrer, L. A. (2015) · American Journal of Primatology · doi:10.1002/ajp.22413 · Cited by 6
Expression profiles and functional annotation analysis of mRNAs in suprachiasmatic nucleus of Clock mutant mice
Wang, Y., Lv, K., Zhao, M., Liang, F., Chen, H., Ji, G., Wang, T., Zhang, Y., Cao, H., Li, Y., et al. (2018) · Gene · doi:10.1016/j.gene.2017.12.056 · Cited by 6
DEC1 directly interacts with estrogen receptor (ER) α to suppress proliferation of ER-positive breast cancer cells
Xue, J., Dai, Y., Li, G., Lang, W., Li, P., Liu, Y., Bao, H., Zhao, D.-L., & Pan, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.123 · Cited by 7
Retinal venous blood carbon monoxide response to bright light in male pigs: A preliminary study
Oren, D. A., Duda, M., Kozioł, K., Romerowicz‐Misielak, M., Koziorowska, A. M., Sołek, P., Nowak, S., Kulpa-Greszta, M., & Koziorowski, M. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.01.016 · Cited by 6
Relationship among depression, fatigue, and sleep after traumatic brain injury: The role of physical exercise as a non-pharmacological therapy
Fiorin, F. D. S., Godinho, D. B., dos Santos, E. B., Aguiar, A. S., Schuch, F. B., de Mello, M. T., Radak, Z. O., Fighera, M. R., & Royes, L. F. F. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115156 · Cited by 7
The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis
Gardner, W., Sarrazin, D. H., Balzinger, M., Marchese, C., Ragno, A., Ramanathan, C., Veleanu, M., Vestring, S., Normann, C., Bourgin, P., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03276-7 · Cited by 5
Amplitude response and singularity behavior of circadian clock to external stimuli
Zhang, T., Liu, Y., & Yang, L. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00300-w · Cited by 5
An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank
Viejo-Romero, M., Whalley, H. C., Shen, X., Stolicyn, A., de Nooij, L., Smıth, D. J., & Howard, D. M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300449 · Cited by 5
Depressive symptom screening in elderly by passive sensing data of smartphones or smartwatches: A systematic review
Adhibai, R., Kosiyaporn, H., Markchang, K., Nasueb, S., Waleewong, O., & Suphanchaimat, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304845 · Cited by 6
Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders
Das, U., Thomas, J. D., Tarale, P., Soja, J., Inkelis, S. M., Chambers, C., & Sarkar, D. K. (2024) · Scientific Reports · doi:10.1038/s41598-024-71023-z · Cited by 5
What can the psychoneuroimmunology of yoga teach us about depression's psychopathology?
Chiarpenello, C., & Brodmann, K. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100877 · Cited by 5
An Updated Review on Possible Therapeutic Role of Vincamine Via 5-HT Receptors in the Treatment of Depression
Bee, R., Ahmad, M. K., Verma, S. K., Badruddeen, B., Akhtar, J., & Khan, M. I. (2023) · Current Psychiatry Research and Reviews · doi:10.2174/2666082219666230726123452 · Cited by 5
Perspectives on depression—past, present, futurea
Barchas, J. D., & Brody, B. D. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12773 · Cited by 7
Self-citation
Comparative analysis of the daily brain transcriptomes of Asian particolored bat
Zhang, G., Chu, Y., Jiang, T., Li, J., Feng, L., Wu, H., Wang, H., & Feng, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-07787-z · Cited by 5
Self-citation
Circadian neuromarkers of mood disorders
Agnorelli, C., & Fagiolini, A. M. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100384 · Cited by 6
Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor
Hatakama, H., Asaoka, N., Nagayasu, K., Shirakawa, H., & Kaneko, S. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02731-3 · Cited by 5
Genetics of human brain evolution
Vallender, E. J. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.01.003 · Cited by 5
Construction of gene-classifier and co-expression network analysis of genes in association with major depressive disorder
Guo, D., Zhang, S., Tang, Z., & Wang, H. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113387 · Cited by 6
Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stressPreprint
Wu, Z., Fu, Y., Yang, Y., Huang, C., Zheng, C., Guo, Z., Yang, Z., Chen, X., Zhu, J., Wang, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/435867 · Cited by 5
Statistical Methods for Detecting Circadian Rhythmicity and Differential Circadian Patterns with Repeated Measurement in Transcriptomic ApplicationsPreprint
Ding, H., Meng, L., Xing, C.-G., Esser, K., & Huo, Z.-G. (2022) · bioRxiv · doi:10.1101/2022.06.05.494875 · Cited by 3
Chronotype, cognitive outcomes, and neural dynamics: recent evidence and potential mechanisms with implications for perioperative period
Liu, Y., Liu, Q., Gao, B., Fu, Q., Li, F., Yu-hu, M., & Liu, Y. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1649396 · Cited by 4
Role of chronotype in depression
Zhao, Y., Liao, J., & Huang, Q. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i10.109087 · Cited by 7
Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning
Shi, Y., Zhu, J., Hou, C., Li, X., & Tong, Q. (2024) · Aging · doi:10.18632/aging.205930 · Cited by 4
Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome
Zhao, J., Xue, J., Zhu, T., He, H., Kang, H., Jiang, X. J., Huang, W., & Duan, R. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00682-z · Cited by 4
Low circadian amplitude and delayed phase are linked to seasonal affective disorder (SAD)
Dhawka, L., Cha, Y., Ay, A. A., & Ingram, K. K. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100395 · Cited by 6
God save the owls! Religiosity moderates the relationship between morningness-eveningness and depressive symptoms
Gorgol, J., Stolarski, M., & Łowicki, P. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2131563 · Cited by 5
Effects of memantine on mania‐like phenotypes exhibited by Drosophila Shaker mutants
Mocci, I., Casu, M. A., Sogos, V., Liscia, A. M., Angius, R., Cadeddu, F., Fanti, M., Muroni, P., Talani, G., Diana, A., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14145 · Cited by 3
Comparative rhythmic transcriptome profiling of human and mouse striatal subregions
Petersen, K. A., Zong, W., DePoy, L. M., Scott, M. R., Shankar, V. G., Burns, J. N., Cerwensky, A. J., Kim, S.-M., Ketchesin, K. D., Tseng, G. C., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01788-w · Cited by 5
Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs
Kong, Y., Wang, Z., Jia, Y., Li, P., Hao, S., & Wang, Y. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1196463 · Cited by 4
Gene Signatures Associated with Temporal Rhythm as Diagnostic Markers of Major Depressive Disorder and Their Role in Immune Infiltration
Wang, J., Ai, P., Sun, Y. E., Shi, H., Wu, A., & Wei, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911558 · Cited by 4
A Nile rat transcriptomic landscape across 22 organs by ultra-deep sequencing and comparative RNA-seq pipeline (CRSP)
Toh, H., Bagheri, A., Dewey, C. N., Stewart, R. M., Yan, L., Clegg, D., Thomson, J. A., & Jiang, P. (2022) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2022.107795 · Cited by 5
Inferring circadian gene regulatory relationships from gene expression data with a hybrid framework
Hu, S., Jing, Y., Li, T., Wang, Y., Liu, Z., Gao, J., & Tian, Y. (2023) · BMC Bioinformatics · doi:10.1186/s12859-023-05458-y · Cited by 4
Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism
Dumas, G., Goubran-Botros, H., Matondo, M., Pagan, C., Boulègue, C., Chaze, T., Chamot-Rooke, J., Maronde, E., & Bourgeron, T. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12713 · Cited by 3
The relationships between clinical characteristics, alcohol and psychotropic exposure, and circadian gene expression in human postmortem samples of affective disorder and control subjects
Gonzalez, R., Bernardo, C., Cruz, D. A., Walss‐Bass, C., & Thompson, P. M. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.048 · Cited by 4
Sex-specific association between the albumin D–element binding protein gene and metabolic syndrome in patients with bipolar disorder and schizophrenia
Kim, E. Y., Kim, S. H., Lee, H. J., Kim, B., Kim, Y. S., & Ahn, Y. M. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.03.040 · Cited by 4
The development of a forensic clock to determine time of death
Sibbens, L., de Voorde, W. V., Decorte, R., & Bekaert, B. (2017) · Forensic science international. Genetics supplement series · doi:10.1016/j.fsigss.2017.09.059 · Cited by 4
The Underrated Circadian System and Its Contribution to Neurodegeneration in Mood Disorders
Hardeland, R. (2018) · JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY · doi:10.29245/2578-2959/2018/3.1128 · Cited by 4
Clock genes Period 1 and Period 2 in the hippocampal CA1 mediate depression-like behaviors and rapid antidepressant responsePreprint
Xl, W., Liu, X., Yuan, K., Han, Y., Xue, Y.-X., Meng, S., & Li, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.14.456364 · Cited by 4
Ketamine treatment effects on DNA methylation and Epigenetic Biomarkers of agingPreprint
Dawson, K., Carangan, A. M. J. M., Klunder, J., Carreras-Gallo, N., Sehgal, R., Megilligan, S., Askins, B. C., Perkins, N., Mendez, T. L., Smith, R. C., et al. (2024) · medRxiv · doi:10.1101/2024.09.10.24313258 · Cited by 4
Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse LiverPreprint
Tong, C.-Y., Li, C., Jacq, A., Nie, X. Y., Guy, C. R., Suh, J. H., Wong, R. K. W., Merlin, C., Menet, J. S., & Jiang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.03.647044 · Cited by 4
A Comparative Study of Algorithms Detecting Differential Rhythmicity in Transcriptomic Data
Miao, L., Weidemann, D. E., Ngo, K., Unruh, B. A., & Kojima, S. (2024) · Bioinformatics and Biology Insights · doi:10.1177/11779322241281188 · Cited by 3
Neuroimmunomodulation: The History of Science in Psychoneuroimmunology
Kuhn, A. M., Bosis, K. E., & Wohleb, E. S. (2024) · NeuroImmunoModulation · doi:10.1159/000541592 · Cited by 5
Retinal Disorders and Sleep Disorders: Are They Genetically Related?
Murphy, C. E., Duponsel, N., Huang, X., Wittich, W., Koenekoop, R. K., & Overbury, O. (2015) · Journal of Visual Impairment & Blindness · doi:10.1177/0145482x1510900505 · Cited by 3
Exercise alters molecular rhythms in the central nervous system that negatively correlate with depression-like behavior
Yu, L., Xue, H., & Li, Z. (2024) · Neuroreport · doi:10.1097/wnr.0000000000001994 · Cited by 3
Integrative neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder
Dias, H. D., Adri, A. S., Nóbile, A. L., de Oliveira, M. G., Chung, E. N., Bahia, I. A. F., Fonseca, D. L. M., Schimke, L. F., Filgueiras, I. S., Barcelos, P. M., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03776-8 · Cited by 4
Ketamine affects homeostatic sleep regulation in the absence of the circadian sleep-regulating component in freely moving rats
Tóth, A., Sviatkó, K., Détári, L., & Hajnik, T. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173556 · Cited by 3
Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance to Psychiatric Disease
Jenkins, A. K., Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.05.007 · Cited by 3
A Corrected Score Function Framework for Modelling Circadian Gene Expression
Gorczyca, M. T., McDonald, T. M., & Sefas, J. (2024) · Stat · doi:10.1002/sta4.70007 · Cited by 3
Individual patterns of activity predict the response to physical exercise as an intervention in mild to moderate depression
Spulber, S. D., Ceccatelli, S., & Forsell, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.01.097 · Cited by 3
Weighted Trigonometric Regression for Suboptimal Designs in Circadian Transcriptome Studies
Gorczyca, M. T., & Sefas, J. (2025) · Statistics in Medicine · doi:10.1002/sim.70201 · Cited by 4
Circadian rhythm of brain activity estimated using visual synchronization tasks
Aoki, K. (2017) · International Conference on Bioinformatics and Computational Biology (ICBCB) · doi:10.1145/3035012.3035028 · Cited by 3
Basic Circadian Timing and Sleep-Wake Regulation
Cuesta, M., Boudreau, P., & Boivin, D. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_6 · Cited by 4
Circadian Clocks, Stress, and Psychiatric Disorders
Kling, C., & Landgraf, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00008-x · Cited by 3
Alteration in circadian rhythms in bipolar disorder: Mechanisms and implications
Dallaspezia, S., & Benedetti, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00010-7 · Cited by 4
How a Disrupted Clock may Cause a Decline in Learning and Memory
Colwell, C. S. (2015) · Wiley eBooks · doi:10.1002/9781118467831.ch16 · Cited by 4
A Systems-Level Framework for Drug Discovery Identifies Csf1R As A Novel Anti-Epileptic Drug TargetPreprint
Srivastava, P. K., van Eyll, J. M., Godard, P., Mazzuferi, M., Danis, B., Vandenplas, C., Foerch, P., Leclercq, K., Mairet‐Coello, G., Vanclef, F., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/140087 · Cited by 3
Age-associated different transcriptome profiling in zebrafish and rat: insight into diversity of vertebrate agingPreprint
Kijima, Y., Wantong, W., Igarashi, Y., Yoshitake, K., Asakawa, S., Suzuki, Y., Watabe, S., & Kinoshita, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/478438 · Cited by 3
Local genetic correlation analysis links depression with molecular and brain imaging endophenotypesPreprint
Werme, J., Tissink, E., de Lange, S. C., van den Heuvel, M. P., Danielle Posthuma, B., & de Leeuw, C. (2023) · medRxiv · doi:10.1101/2023.03.01.23286613 · Cited by 3
Limits to the inference of gene regulation from bulk tissue expression dataPreprint
Chu, E. C.-P., Morin, A. M., & Pavlidis, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.24.619521 · Cited by 3
Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunctionPreprint
Cely, I., Blencowe, M., Shu, L., Diamante, G., Ahn, I., Zhang, G., LaGuardia, J. S., Liu, R., Saleem, Z., Wang, S. S.-M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634754 · Cited by 3
Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease modelPreprint
Gelber, A., Romero, H. K., Burrows, D. R. W., Whittaker, D. S., Carlin, D. E., Mukamel, E. A., & Desplats, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701799 · Cited by 3
Dysregulation of circadian clock gene expression patterns in a treatment‐resistant animal model of depression
Højgaard, K., Kaadt, E., Mumm, B. H., Pereira, V. S., & Elfving, B. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16172 · Cited by 2
A network analysis of gene co-expression in post-mortem brain tissues identifying novel genes and biological pathways underlying major depression
Yan, M., Chen, M., Jiang, Q. L., Huang, H., & Wu, Y. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1556983 · Cited by 3
Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions
Zhang, Y., Zheng, W., Dai, R., Ma, T., Li, Z., Li, J., & Shen, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-03253-0 · Cited by 2
Self-citation
Prostaglandin F2α exacerbates ovalbumin-induced chronic pneumonia and attenuates depression in mice
Maehara, T., FUJIMURA, A., SEGAWA, R., INOUE, S., & Satoh, H. (2025) · Journal of Veterinary Medical Science · doi:10.1292/jvms.25-0196 · Cited by 2
The relationship between the circadian protein PER and adolescent depression: the mediating effect of aberrant functional connectivity of suprachiasmatic nucleus-orbitofrontal cortex
Guo, Q., Qiao, D., Zhai, P., Zhang, R., Wen, Y., Liu, P., Li, G., & Liu, Z. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.08.001 · Cited by 3
Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study
Dawson, K. L., Carangan, A. M. J. M., Klunder, J., Carreras-Gallo, N., Sehgal, R., Megilligan, S., Askins, B. C., Perkins, N., Mendez, T. L., Smith, R. M., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03683-y · Cited by 9
Circadian Rhythm Disorders: Focusing on Environmental Risk Factors, Interrelationship with Diseases, and Developing Chronotherapy
Li, S., Li, X., Nan, N., Zhang, Y., Yan, Z., Xu, M., Zhang, Y., Chen, R., & Qin, G. (2026) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/s44169-025-00108-1 · Cited by 1
Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts
Sokolov, A. V., Lafta, M. S., Jokinen, J., & Schiöth, H. B. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03978-8 · Cited by 2
Rhythms of mood: Bidirectional regulation of molecular clocks and neurotransmission in affective disorders
Wang, X.-L., & Serchov, T. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106700 · Cited by 2
Defining functional states and roles of microglia in neuropsychiatric disorders
Szydłowska, K., Tivanello, R., & Kaminska, B. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1798151 · Cited by 2
Melatonin, Sleep, Circadian Rhythm, and Mood Disorders
Srinivasan, V., Berardis, D. D., Fornaro, M., Lopez-Munoz, F. J., Partonen, T., & Zakaria, R. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_9 · Cited by 2
Clock Genes in Depression
Christiansen, S. L., & Bouzinova, E. V. (2017) · InTech eBooks · doi:10.5772/67261 · Cited by 2
Gene Expression during the Activation of Human B Cells
Zhang, Y. (2018) · InTech eBooks · doi:10.5772/intechopen.71863 · Cited by 2
Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic Stress and Stress-Related Disorders
Coutellier, L. D., Musazzi, L., & Pavlovic, Z. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_4 · Cited by 2
Common Ground between Biological Rhythms and Forensics
Janjić, K., Reisinger, C., & Kanz, F. (2022) · Biology · doi:10.3390/biology11071071 · Cited by 3
Brain Changes Linked to Cognitive Symptomatology in Homeless Youth
Bounds, D. T., Woo, M. A., Nyamathi, A., Kehoe, P., Roy, B., Yadav, K., Cabrera‐Mino, C., & Kumar, R. (2023) · Clinical Nursing Research · doi:10.1177/10547738231168465 · Cited by 2
Antidepressant mechanism of traditional Chinese medicine: Involving regulation of circadian clock genes
Lv, S., Huang, Y., Ma, Y., & Teng, J. (2024) · Medicine · doi:10.1097/md.0000000000036266 · Cited by 2
Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis
Roy, J.-C., Hédouin, R., Desmidt, T., Dam, S., Miréa-Grivel, I., Weyl, L., Bannier, É., Barantin, L., Drapier, D., Batail, J.-M. V., et al. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.04.002 · Cited by 2
Natural Compounds that Modulate Circadian Rhythms
Tomita, T., Wadhwa, R., & Onishi, Y. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266300569240514101800 · Cited by 2
Circadian Rhythms Correlated in DNA Methylation and Gene Expression Identified in Human Blood and Implicated in Psychiatric Disorders
Tang, H., Chen, S., Liu, Y., Xu, S., Yang, H., Li, Z., He, Y., Liao, Y., Chen, X., Liu, C., et al. (2024) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.33005 · Cited by 2
To Stay Happy, Keep Your SIRT1 Active
Chatterjee, S., & Abel, T. G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.014 · Cited by 2
Circadian Clock Genes and Mood Disorders
Partonen, T. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_22 · Cited by 2
Epigenetic Modulation of Circadian Rhythms: Bmal1 Gene Regulation
Tomita, T., & Onishi, Y. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79975 · Cited by 3
Changes in cortical gene expression in major depressive disorders: More evidence implicating inflammatory-related pathways in disease etiology
Dean, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00037-4 · Cited by 2
The blues and rhythm
Imamura, K., Bota, A., Shirafuji, T., & Takumi, T. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.11.004 · Cited by 2
RETRACTED: Diurnal rhythm disruptions induced by chronic unpredictable stress relate to depression-like behaviors in rats
Xl, W., Wang, D.-Q., Jiao, F., Ding, K.-M., Ji, Y., Lü, L., Yuan, K., Gao, G. F., & Li, S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172939 · Cited by 2
Retracted
Biological Rhythm and Neuropsychiatric Disorders
Datta, K. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_3 · Cited by 2
Experimental Design and Power Calculation in Omics Circadian Rhythmicity DetectionPreprint
Zong, W., Seney, M. L., Ketchesin, K. D., Gorczyca, M. T., Liu, A. C., Esser, K. A., Tseng, G. C., McClung, C. A., & Huo, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.19.476930 · Cited by 2
Circadian Disturbances and Age‐Related Disorders
Li, P., & Hu, K. (2023) · Advanced Biology · doi:10.1002/adbi.202300405 · Cited by 2
Keeping time: investigating the relationship between circadian rhythm and mood disorders via precise circadian measurement techniques
Lyman, K. M., & McClung, C. A. (2025) · Research Directions Depression · doi:10.1017/dep.2025.10002 · Cited by 1
Circadian Regulation of Neuronal Membrane Capacitance—Mechanisms and Implications for Neural Computation and Behavior
Nowacka, A., Śniegocki, M., Bożiłow, D., & Ziółkowska, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110766 · Cited by 2
Mechanisms of rumination in depression: neuroendocrine dysregulation, circadian disruption, and therapeutic interventions
Zhu, J., Liu, M., Lu, Z., Dong, X., Zhou, Y., Kang, Y., Cheng, A. S. K., & Xie, J. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.12.027 · Cited by 2
Circulating soluble receptor for advanced glycation end-products as a novel biomarker linking biological rhythm disruption with major depressive disorder: A matched case-control study
Zhang, X., Sun, C., Yuan, S., Li, J., Yang, Y., Tang, X., Zhang, X., & Sun, W. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120912 · Cited by 1
Self-citation
CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems
Santos, J. L. A., Pinto, V. T. B. C., Santos, T. E. D. S., Coimbra, D. G., & de Andrade, T. G. (2026) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00064-y · Cited by 1
Systems genomics reveals age- and sex-dependent metabolic dysregulation from Glo1 reduction in mice
Cely, I., Blencowe, M., Shu, L., Diamante, G., Ahn, I. S., Zhang, G., LaGuardia, J. S., Liu, R., Briscoe, O., Saleem, Z., et al. (2026) · Physiological Genomics · doi:10.1152/physiolgenomics.00106.2025 · Cited by 5
Astrocytes in the Circadian System: A Promising Target for Mood Disorder Interventions
Liu, P., Li, H., Zhu, Y., Song, S., Kang, L., & Hu, Y. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin48501 · Cited by 1
Chronic REM Sleep Deprivation Induces Metabolic and Neurotoxic Alterations Associated with Affective and Cognitive Deficit in Male Wistar Rats: Involvement of HPA Axis, Cholinergic, Inflammatory, and Oxidative Stress Pathways
Baghdad, W., Brouzi, M. Y. E., Ibouzine‐Dine, L., Abouyaala, O., Arbaoui, M. E., Kessam, F. Z., Dimaoui, A., Mallouk, H., Lamtai, M., Satté, A., et al. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04788-6 · Cited by 2
Mammalian torpor and depressive disorders: a review of evidence for a connection
D’Agati, D. V., & D’Agati, D. C. (2026) · International Review of Psychiatry · doi:10.1080/09540261.2026.2753429 · Cited by 1

Authors: Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., Schatzberg, A. F., Jones, E. G., Myers, R. M., Watson, S. J., Akil, H., & Bunney, W. E.
Affiliations: University of Michigan (US)
University of California, Irvine (US)
University of California, Davis (US)
Weill Cornell Medicine (US)
Stanford University (US)
HudsonAlpha Institute for Biotechnology (US)
ORCID: Li, Jun Z.
Bunney, Blynn G.
Meng, Fan
Hagenauer, Megan H.
Walsh, David M.
Vawter, Marquis P.
Evans, Simon J.
Choudary, Prabhakara V.
Barchas, Jack D.
Schatzberg, Alan F.
Jones, Edward G.
Myers, Richard M.
Watson, Stanley J.
Akil, Huda
Bunney, William E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-05-13
Volume: 110
Issue: 24
Pages: 9950-9955
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1305814110
PMC: PMC3683716
OpenAlex: W2027764072
Cited by: 589
References: 59
Citations by year: 2026: 26 · 2025: 37 · 2024: 44 · 2023: 39 · 2022: 52 · 2021: 54 · 2020: 60 · 2019: 49 · 2018: 49 · 2017: 48 · 2016: 35 · 2015: 52 · 2014: 35 · 2013: 9
FWCI: 23.61
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: other-oa
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (NIMH R01MH085801)
National Institute of Mental Health (P50MH60398, R01MH085801, P50MH060398)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: major depressive disorder, circadian rhythm, clock genes, gene expression rhythms, human brain transcriptome, postmortem brain, dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, cerebellum, Bmal1, per gene, DBP, BHLHE40, BHLHE41, mood disorders
MeSH terms: Adult, Aged, Autopsy, Brain, Circadian Rhythm, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Homeodomain Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Basic Helix-Loop-Helix Proteins, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1, Circadian Clocks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks