The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Identification of discrete functional subregions of the human periaqueductal gray
Open accessAbstract
Significance: The periaqueductal gray is a brainstem region that is critical for autonomic regulation and for defensive responses (e.g., “fight,” “flight,” “freeze”). It has been studied extensively in rodents and cats, but less is known about the human periaqueductal gray. The small size and shape of the periaqueductal gray makes it challenging to study using standard noninvasive MRI techniques. We used a high-field strength magnet to examine this region at high resolution while participants viewed emotionally aversive or neutral images. Emotion-related functional activity was concentrated in particular subregions and in ways that are consistent with neurobiological observations in nonhuman animals. This study establishes a technique to uncover the functional architecture of the periaqueductal gray in humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Functional magnetic resonance imaging studies—performed while negatively arousing (aversive) stimuli, including pictures of mutilation and injury in humans, are being processed—provide clear evidence of PAG activation82,83 and suggest increased functional connectivity between the amygdala and PAG, coupled with a bradycardic effect.84”
From Fear and the Defense Cascade (2015) · cites this paper as [83]
Citations
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Jenkinson, M., Beckmann, C. F., Behrens, T. E. J., Woolrich, M. W., & Smith, S. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.015 · Cited by 11,314
(2005) · CTIT technical reports series · Cited by 5,307
Russell, J. A., & Barrett, L. F. (1999) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.76.5.805 · Cited by 3,355
Self-citationStatistical Parametric Mapping: The Analysis of Functional Brain Images
Penny, W. D., Friston, K. J., Ashburner, J., Kiebel, S. J., & Thomas, N. (2007) · UCL Discovery (University College London) · Cited by 3,339
Bayesian analysis of neuroimaging data in FSL
Woolrich, M. W., Jbabdi, S., Patenaude, B., Chappell, M., Makni, S., Behrens, T., Beckmann, C., Jenkinson, M., & Smith, S. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.055 · Cited by 2,385
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320 · cited 1×
“To date, dozens of human neuroimaging studies have observed increased activation in the vicinity of the PAG during administration of painful and aversive stimuli (8, 12–16) and across a variety of emotional states (17).”
BackgroundSelf-citationSolving the Emotion Paradox: Categorization and the Experience of Emotion
Barrett, L. F. (2006) · Personality and Social Psychology Review · doi:10.1207/s15327957pspr1001_2 · Cited by 1,823
Self-citationExploratory Factor Analysis With Small Sample Sizes
de Winter, J., Dodou, D., & Wieringa, P. A. (2009) · Multivariate Behavioral Research · doi:10.1080/00273170902794206 · Cited by 1,211
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146
Research works printed but not linked: 1
- Keil B Triantafyllou C Hamm M Wald L (2010) Design optimization of a 32-channel head coil at 7 T. Proceedings of the International Society of Magnetic Resonance in Medicine (Stockholm) p 1493.
Cited by
Sorted by citations
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Self-citationEvidence for a large-scale brain system supporting allostasis and interoception in humans
Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C., & Feldman Barrett, L. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0069 · Cited by 641
Self-citationFreeze for action: neurobiological mechanisms in animal and human freezing
Roelofs, K. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0206 · Cited by 653
The hierarchical basis of neurovisceral integration
Smith, R., Thayer, J. F., Khalsa, S. S., & Lane, R. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.003 · Cited by 523
Kozlowska, K., Walker, P., McLean, L., & Carrive, P. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000065 · Cited by 468
Metadata
- Authors
- Satpute, A. B., Wager, T. D., Cohen-Adad, J., Bianciardi, M., Choi, J.-K., Buhle, J. T., Wald, L. L., & Barrett, L. F.
- Affiliations
- Northeastern University (US)
- University of Colorado Boulder (US)
- Department of Electrical Engineering, École Polytechnique de Montréal, Montreal, QC, Canada H3T 1J4;
- Departments of dRadiology and
- Columbia University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-09-30
- Volume
- 110
- Issue
- 42
- Pages
- 17101-17106
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3801046
- OpenAlex
- W2100827912
- Cited by
- 131
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 14 · 2017: 19 · 2016: 17 · 2015: 15 · 2014: 5
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PolyPublie (École Polytechnique de Montréal) (submittedVersion)
- Funders
- U.S. Department of Defense
- Massachusetts General Hospital (P41EB015896)
- Centre d'Imagerie BioMédicale
- National Institutes of Health (1s10rr019307-01, DP1OD003312, 1s10rr023043-01)
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (P41-EB015896, S10 RR023401)
- National Institute of Mental Health (R01MH076136, R21MH082308)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015896)
- National Center for Research Resources (S10-RR019307, S10-RR-023043, S10RR023401)
- Army Research Institute for the Behavioral and Social Sciences (W5J9CQ-11-C-0046)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- periaqueductal gray, midbrain, rostrocaudal axis, dorsal-ventral axis, anger, sadness, survival response
- MeSH terms
- Adult, Anger, Female, Humans, Magnetic Resonance Imaging, Male, Mesencephalon, Radiography, Stress, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
