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Identification of discrete functional subregions of the human periaqueductal gray

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Satpute, Ajay B., Wager, Tor D., Cohen-Adad, Julien, Bianciardi, Marta, Choi, Ji-Kyung, Buhle, Jason T., Wald, Lawrence L., Barrett, Lisa Feldman·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1306095110PMC PMC3801046

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Abstract

Significance: The periaqueductal gray is a brainstem region that is critical for autonomic regulation and for defensive responses (e.g., “fight,” “flight,” “freeze”). It has been studied extensively in rodents and cats, but less is known about the human periaqueductal gray. The small size and shape of the periaqueductal gray makes it challenging to study using standard noninvasive MRI techniques. We used a high-field strength magnet to examine this region at high resolution while participants viewed emotionally aversive or neutral images. Emotion-related functional activity was concentrated in particular subregions and in ways that are consistent with neurobiological observations in nonhuman animals. This study establishes a technique to uncover the functional architecture of the periaqueductal gray in humans.

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Authors: Satpute, A. B., Wager, T. D., Cohen-Adad, J., Bianciardi, M., Choi, J.-K., Buhle, J. T., Wald, L. L., & Barrett, L. F.
Affiliations: Northeastern University (US)
University of Colorado Boulder (US)
Department of Electrical Engineering, École Polytechnique de Montréal, Montreal, QC, Canada H3T 1J4;
Departments of dRadiology and
Columbia University (US)
ORCID: Satpute, Ajay B.
Wager, Tor D.
Bianciardi, Marta
Choi, Ji-Kyung
Wald, Lawrence L.
Barrett, Lisa Feldman
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-09-30
Volume: 110
Issue: 42
Pages: 17101-17106
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1306095110
PMC: PMC3801046
OpenAlex: W2100827912
Cited by: 131
References: 44
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 14 · 2017: 19 · 2016: 17 · 2015: 15 · 2014: 5
FWCI: 6.76
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
PolyPublie (École Polytechnique de Montréal) (submittedVersion)
Funders: U.S. Department of Defense
Massachusetts General Hospital (P41EB015896)
Centre d'Imagerie BioMédicale
National Institutes of Health (1s10rr019307-01, DP1OD003312, 1s10rr023043-01)
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (P41-EB015896, S10 RR023401)
National Institute of Mental Health (R01MH076136, R21MH082308)
National Institute of Biomedical Imaging and Bioengineering (P41EB015896)
National Center for Research Resources (S10-RR019307, S10-RR-023043, S10RR023401)
Army Research Institute for the Behavioral and Social Sciences (W5J9CQ-11-C-0046)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: periaqueductal gray, midbrain, rostrocaudal axis, dorsal-ventral axis, anger, sadness, survival response
MeSH terms: Adult, Anger, Female, Humans, Magnetic Resonance Imaging, Male, Mesencephalon, Radiography, Stress, Physiological

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Identification of discrete functional subregions of the human periaqueductal gray

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