Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity

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Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques

Rafnsson, A. T., Matic, L. P., Lengquist, M., Mahdi, A., Shemyakin, A. S., Paulsson‐Berne, G., Hansson, G. K., Gabrielsen, A., Hedin, U., Yang, J., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.09.020 · Cited by 34 · see citing works

The role of arginase in aging: A systematic review

Moretto, J., Girard, C., & Demougeot, C. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.12.011 · Cited by 34 · see citing works

Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I

Zhuge, Z., Haworth, S. M., Nihlén, C., Carvalho, L. R. R. A., Heuser, S. K., Kleschyov, A. L., Nasiell, J., Cortese-Krott, M. M., Weitzberg, E., Lundberg, J. O., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102612 · Cited by 32 · see citing works

Arginine metabolism is a biomarker of red blood cell and human aging

Reisz, J. A., Earley, E. J., Nemkov, T. G., Key, A., Stephenson, D., Keele, G. R., Dzieciątkowska, M., Spitalnik, S. L., Hod, E. A., Kleinman, S. H., et al. (2024) · Aging Cell · doi:10.1111/acel.14388 · Cited by 31 · see citing works

Dietary nitrate improves cardiac contractility via enhanced cellular Ca2+ signaling

Pironti, G., Ivarsson, N., Yang, J., Farinotti, A. B., Jonsson, W. O., Zhang, S., Bas, D. B., Svensson, C. I., Westerblad, H., Weitzberg, E., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0551-8 · Cited by 30 · see citing works

Red blood cell eNOS is cardioprotective in acute myocardial infarction

Cortese-Krott, M. M., Suvorava, T., Leo, F., Heuser, S. K., LoBue, A., Li, J., Becher, S., Schneckmann, R., Srivrastava, T., Erkens, R., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102370 · Cited by 29 · see citing works

Arginase as a target for treatment of myocardial ischemia-reperfusion injury

Tratsiakovich, Y., Yang, J., Gonon, A. T., Sjöquist, P.-O. B., & Pernow, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.040 · Cited by 29 · see citing works

Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart

Schlüter, K., Schulz, R., & Schreckenberg, R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00065 · Cited by 27 · see citing works

Role of Erythrocytes in Nitric Oxide Metabolism and Paracrine Regulation of Endothelial Function

Gajecki, D., Gawryś, J., Szahidewicz-Krupska, E., & Doroszko, A. (2022) · Antioxidants · doi:10.3390/antiox11050943 · Cited by 27 · see citing works

The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia

Mahdi, A., Wodaje, T., Kövamees, O., Tengbom, J., Zhao, A. Z., Jiao, T., Henricsson, M., Yang, J., Zhou, Z., Nieminen, A. I., et al. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13580 · Cited by 27 · see citing works

Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies

Pagliaro, P., Weber, N. C., Femminò, S., Alloatti, G., & Penna, C. R. R. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01061-1 · Cited by 26 · see citing works

The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes

Mahdi, A., Jiao, T., Yang, J., Kövamees, O., Alvarsson, M., von Heijne, M., Zhou, Z., & Pernow, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00861 · Cited by 26 · see citing works

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

LoBue, A., Heuser, S. K., Lindemann, M., Li, J., Rahman, M., Kelm, M., Stegbauer, J., & Cortese-Krott, M. M. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16230 · Cited by 28 · see citing works

Cellular microdomains for nitric oxide signaling in endothelium and red blood cells

Leo, F., Hutzler, B., Ruddiman, C. A., Isakson, B. E., & Cortese-Krott, M. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.002 · Cited by 27 · see citing works

An Integrated Analysis of Metabolites, Peptides, and Inflammation Biomarkers for Assessment of Preanalytical Variability of Human Plasma

Cao, Z., Kamlage, B., Wagner-Golbs, A., Maisha, M. P., Sun, J., Schnackenberg, L. K., Pence, L. M., Schmitt, T. C., Daniels, J. R., Rogstad, S., et al. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00903 · Cited by 25 · see citing works

Biological Assessment of the NO-Dependent Endothelial Function

Boughaleb, H., Lobysheva, I. I., Zotti, F. D., Balligand, J., & Montiel, V. (2022) · Molecules · doi:10.3390/molecules27227921 · Cited by 25 · see citing works

Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes

Collado, A., Humoud, R., Kontidou, E., Eldh, M., Swaich, J., Zhao, A., Yang, J., Jiao, T., Domingo, E., Carlestål, E., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci180900 · Cited by 24 · see citing works

Nitrosyl-hemoglobin formation in rodent and human venous erythrocytes reflects NO formation from the vasculature in vivo

Zotti, F. D., Lobysheva, I. I., & Balligand, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200352 · Cited by 23 · see citing works

Erythrocytes of Little Ground Squirrels Undergo Reversible Oxidative Stress During Arousal From Hibernation

Кличханов, Н. К., Nikitina, E. R., Shihamirova, Z. M., Astaeva, M. D., Чалабов, Ш. И., & Krivchenko, A. I. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730657 · Cited by 22 · see citing works

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Grau, M., Jerke, M., Nader, É., Schenk, A., Renoux, C., Collins, B., Dietz, T., Bizjak, D. A., Joly, P., Bloch, W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48364-1 · Cited by 22 · see citing works

Redox regulation of nitrosyl-hemoglobin in human erythrocytes

Zotti, F. D., Verdoy, R., Brusa, D., Lobysheva, I. I., & Balligand, J. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101399 · Cited by 22 · see citing works

Red blood cells from patients with pre-eclampsia induce endothelial dysfunction

Haworth, S. M., Zhuge, Z., Nihlén, C., Rosen, M. F. V., Weitzberg, E., Lundberg, J. O., Krmar, R. T., Nasiell, J., & Carlström, M. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002834 · Cited by 21 · see citing works

Hypobaric hypoxia induced arginase expression limits nitric oxide availability and signaling in rodent heart

Singh, M., Padhy, G., Vats, P., Bhargava, K., & Sethy, N. K. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.015 · Cited by 22 · see citing works

Biomarkers of Coronary Microvascular Dysfunction in Patients With Microvascular Angina: A Narrative Review

Sucato, V., Corrado, E., Manno, G., Amata, F., Testa, G., Novo, G., & Galassi, A. R. (2022) · Angiology · doi:10.1177/00033197211034267 · Cited by 21 · see citing works

Red Blood Cells as a “Central Hub” for Sulfide Bioactivity: Scavenging, Metabolism, Transport, and Cross-Talk with Nitric Oxide

Cortese-Krott, M. M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8171 · Cited by 20 · see citing works

Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells

Gogiraju, R., Renner, L. V., Bochenek, M. L., Zifkos, K., Molitor, M., Danckwardt, S., Wenzel, P., Münzel, T. F., Konstantinides, S., & Schäfer, K. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318338 · Cited by 20 · see citing works

Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart

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Extracellular ATP activates eNOS and increases intracellular NO generation in Red Blood Cells

Ülker, P., Özen, N., Abdullayeva, G., Köksoy, S., Yaraş, N., & Basralı, F. (2017) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-170326 · Cited by 19 · see citing works

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1+ stem cells from young donors

Wlodarek, L., Cao, F., Alibhai, F. J., Fekete, Á., Noyan, N., Tobin, S. W., Marvasti, T. B., Wu, J., Li, S., Weisel, R. D., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1681-3 · Cited by 19 · see citing works

Nitric Oxide Synthetic Pathway in Patients with Microvascular Angina and Its Relations with Oxidative Stress

Porro, B., Eligini, S., Veglia, F., Lualdi, A., Squellerio, I., Fiorelli, S., Giovannardi, M., Chiorino, E., Cia, A. D., Crisci, M., et al. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/726539 · Cited by 19 · see citing works

Regulatory effects of curcumin on nitric oxide signaling in the cardiovascular system

Abolfazli, S., Mortazavi, P., Kheirandish, A., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.12.003 · Cited by 18 · see citing works

Effects of a chronic l -arginine supplementation on the arginase pathway in aged rats

Moretto, J., Guglielmetti, A.-S., Tournier-Nappey, M., Martin, H., Prigent‐Tessier, A., Marie, C., & Demougeot, C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.023 · Cited by 18 · see citing works

The role of arginase in the microcirculation in cardiovascular disease

Wernly, B., Pernow, J., Kelm, M., & Jung, C. (2019) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-199237 · Cited by 18 · see citing works

The red blood cell: a new key player in cardiovascular homoeostasis? Focus on the nitric oxide pathway

Porro, B., Eligini, S., Squellerio, I., Tremoli, E., & Cavalca, V. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140122 · Cited by 18 · see citing works

Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP

Yang, J., Sundqvist, M. L., Zheng, X., Jiao, T., Collado, A., Tratsiakovich, Y., Mahdi, A., Tengbom, J., Mergia, E., Catrina, S., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167693 · Cited by 17 · see citing works

Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil

Lacchini, R., Muniz, J. J., Nobre, Y. T. D. A., Cologna, A. J., Martins, A. C. P., & Tanus-Santos, J. E. (2017) · The Pharmacogenomics Journal · doi:10.1038/tpj.2017.2 · Cited by 17 · see citing works

Influence of Nitric Oxide generated through microwave plasma on L6 skeletal muscle cell myogenesis via oxidative signaling pathways

Kumar, N., Shaw, P., Uhm, H. S., Choi, E. H., & Attri, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-00154-3 · Cited by 16 · see citing works

Nitrite in breast milk: roles in neonatal pathophysiology

Kobayashi, J. (2020) · Pediatric Research · doi:10.1038/s41390-020-01247-y · Cited by 16 · see citing works

Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y13 receptor and nitric oxide signaling

Jiao, T., Collado, A., Mahdi, A., Jurga, J., Tengbom, J., Saleh, N., Verouhis, D., Böhm, F., Zhou, Z., Yang, J., et al. (2022) · Basic Research in Cardiology · doi:10.1007/s00395-022-00953-4 · Cited by 16 · see citing works

Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

Mahdi, A., Tratsiakovich, Y., Tengbom, J., Jiao, T., Garib, L., Alvarsson, M., Yang, J., Pernow, J., & Zhou, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603226 · Cited by 16 · see citing works

Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients

Wang, S., FANG, F., JIN, W.-B., Wang, X., & ZHENG, D.-W. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1768 · Cited by 16 · see citing works

Arginase 1 is upregulated at admission in patients with ST‐elevation myocardial infarction

Tengbom, J., Cederström, S., Verouhis, D., Böhm, F., Eriksson, P. O., Folkersen, L., Gabrielsen, A., Jernberg, T., Lundman, P., Persson, J., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13358 · Cited by 15 · see citing works

The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

Ng, K. P., Manjeri, A., Lee, L. M., Chan, Z. E., Tan, C. Y., Tan, Q. D., Majeed, A., Lee, K. L., Chuah, C. T. H., Suda, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205254 · Cited by 14 · see citing works

Effects of inorganic nitrate on ischaemia-reperfusion injury after coronary artery bypass surgery: a randomised controlled trial

Eriksson, K. E., Eidhagen, F., Liška, J., Franco‐Cereceda, A., Lundberg, J. O., & Weitzberg, E. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.06.046 · Cited by 13 · see citing works

A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization

Zhang, R., Liu, Q., Pan, S., Zhang, Y., Qin, Y., Du, X., Yuan, Z., Lu, Y., Song, Y., Zhang, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41309-3 · Cited by 11 · see citing works

Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte’s arginase activation

Harisa, G. I., Attia, S. M., Zoheir, K. M. A., & Alanazi, F. K. (2016) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2016.05.007 · Cited by 11 · see citing works

Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes

Jiao, T., Collado, A., Mahdi, A., Tengbom, J., Tratsiakovich, Y., Milne, G. T., Alvarsson, M., Lundberg, J. O., Zhou, Z., Yang, J., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.02.017 · Cited by 11 · see citing works

Functions and Mechanisms of Arginase in Age-Associated Cardiovascular Diseases

Ming, X., & Yang, Z. (2013) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-013-0060-7 · Cited by 11 · see citing works

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Srivastava, S. C., & Ghosh, S. K. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.16.7031 · Cited by 11 · see citing works

Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation

Hellhammer, K. (2016) · World Journal of Cardiology · doi:10.4330/wjc.v8.i2.220 · Cited by 11 · see citing works

Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma

Douguet, L., Bod, L., Démolis, L. L., Lengagne, R., Kato, M., Couillin, I., & Prévost‐Blondel, A. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1484979 · Cited by 11 · see citing works

The redox physiology of red blood cells and platelets: implications for their interactions and potential use as systemic biomarkers

Cortese-Krott, M. M., & Shiva, S. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.016 · Cited by 11 · see citing works

Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases

Moretto, J., Pudlo, M., & Demougeot, C. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.005 · Cited by 11 · see citing works

Role of dietary fish oil on nitric oxide synthase activity and oxidative status in mice red blood cells

Martins, M. A., Moss, M. B., Mendes, I. K. S., Águila, M. B., Mandarim‐de‐Lacerda, C. A., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2014) · Food & Function · doi:10.1039/c4fo00055b · Cited by 10 · see citing works

Arginase regulates formation and export of cardioprotective nitric oxide bioactivity from red blood cells

Yang, J., Gonon, A. T., Sjöquist, P.-O. B., Lundberg, J. O., & Pernow, J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht308.767 · Cited by 1 · see citing works

P4599Impact of cardiovascular risk factors on erythrocrine function in the setting of ischemia/reperfusion-injury in a Langendorff heart model

Moellhoff, L., Muessig, J. M., Noelle, J., Kaya, S., Masyuk, M., Nia, A. M., Kelm, M., & Jung, C. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy563.p4599

Arginase 1 in erythrocytes is a critical modulator of cardioprotective signalling by nitric oxide and soluble guanylyl cyclase

Yang, J., Tratsiakovich, Y., Jiao, T., Mahdi, A., Tengbom, J., Zhou, Z., Collado, A., Lundberg, J. O., & Pernow, J. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac544.2921

Differentiation between arginase 1 and 2 in regulating tolerance to cardiac ischemia-reperfusion via nitric oxide signaling by red blood cells

Yang, J. N., Tratsiakovich, Y., Cao, R. H., Jiao, T., Humoud, R., Kontidou, E., Tengbom, J., Collado, A., Mahdi, A. M. A., Zhou, Z. Z. Z., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf784.4685

Role of arginase in vascular function

(18637399), C. L. (2024) · Figshare