An S -nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
Abstract
Red blood cells (RBCs) act as O(2)-responsive transducers of vasodilator and vasoconstrictor activity in lungs and tissues by regulating the availability of nitric oxide (NO). Vasodilation by RBCs is impaired in diseases characterized by hypoxemia. We have proposed that the extent to which RBCs constrict vs. dilate vessels is, at least partly, controlled by a partitioning between NO bound to heme iron and to Cysbeta93 thiol of hemoglobin (Hb). Hemes sequester NO, whereas thiols deploy NO bioactivity. In recent work, we have suggested that specific micropopulations of NO-liganded Hb could support the chemistry of S-nitrosohemoglobin (SNO-Hb) formation. Here, by using nitrite as the source of NO, we demonstrate that a (T state) micropopulation of a heme-NO species, with spectral and chemical properties of Fe(III)NO, acts as a precursor to SNO-Hb formation, accompanying the allosteric transition of Hb to the R state. We also show that at physiological concentrations of nitrite and deoxyHb, a S-nitrosothiol precursor is formed within seconds and produces SNO-Hb in high yield upon its prompt exposure to O(2) or CO. Deoxygenation/reoxygenation cycling of oxyHb in the presence of physiological amounts of nitrite also efficiently produces SNO-Hb. In contrast, high amounts of nitrite or delays in reoxygenation inhibit the production of SNO-Hb. Collectively, our data provide evidence for a physiological S-nitrosothiol synthase activity of tetrameric Hb that depends on NO-Hb micropopulations and suggest that dysfunction of this activity may contribute to the pathophysiology of cardiopulmonary and blood disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several proposed mechanisms explain how nitrite-derived bioactivity can be exported from the red blood cell, generally involving either a compartment model with submembrane localization or formation of another nitrogen oxide such as a nitrosothiol or N2O3.
“Several proposed mechanisms have been constructed to explain how nitrite-derived bioactivity can be exported from the red blood cell and these generally involve either a compartment model with submembrane localization of the reaction allowing for inefficient free NO escape, or the formation of another nitrogen oxide such as a nitrosothiol or N2O3 that can get out of the red blood cell and carry NO”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [50]
Exogenous administration of nitrite correlates with increased levels of S-nitrosothiols in red blood cells and other tissues both in vivo and in vitro.
“exogenous administration of nitrite correlates with increased levels of S-nitrosothiols in red blood cells and other tissues both in vivo and in vitro [25, 43, 46-53].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [46]
Nitrite supplementation to intact organisms is associated with a widespread increase in the concentration of nitrite and production of NO-derived species such as S-nitrosothiols or nitrosylhemes in several tissues.
“Many reports show that nitrite supplementation to intact organisms is associated with a widespread increase in the concentration of this anion and production of NO-derived species such as S-nitrosothiols or nitrosylhemes in several tissues[25, 43, 46, 48, 49, 96].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [46]
A potential mechanism by which nitrite could induce cGMP-independent effects is S-nitrosation of cysteine residues, a potential nitrite-induced post-translational modification that can alter protein function.
“A potential mechanism by which nitrite could induce cGMP-independent effects is S-nitrosation of cysteine residues, which is being increasingly recognized as a potential nitrite-induced post-translational modification that can alter protein function[17, 43, 46, 47, 51, 96].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works
Kirkwood, B. R., & Sterne, J. A. C. (2014) · Bristol Research (University of Bristol) · Cited by 2,820 · see citing works
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,586 · see citing works
Self-citationBlood Flow Regulation by <i>S</i> -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050 · see citing works
Self-citationExport by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579 · see citing works
Self-citationReactions between nitric oxide and haemoglobin under physiological conditions
Gow, A. J., & Stamler, J. S. (1998) · Nature · doi:10.1038/34402 · Cited by 562 · see citing works
Self-citationEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
Liu, L., Yan, Y., Zeng, M., Zhang, J., Hanes, M. A., Ahearn, G. S., McMahon, T., Dickfeld, T. L., Marshall, H. E., Que, L. G., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00131-x · Cited by 546 · see citing works
Self-citationEnzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520 · see citing works
Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481 · see citing works
Self-citationNitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462 · see citing works
Self-citationRate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin
Doherty, D. H., Doyle, M. P., Curry, S. R., Vali, R. J., Fattor, T., Olson, J. S., & Lemon, D. D. (1998) · Nature Biotechnology · doi:10.1038/nbt0798-672 · Cited by 428 · see citing works
The oxyhemoglobin reaction of nitric oxide
Gow, A. J., Luchsinger, B. P., Pawloski, J. R., Singel, D. J., & Stamler, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9027 · Cited by 414 · see citing works
Self-citationThe molecular basis of blood diseases
Kazazian, H. H. (1988) · Cell · doi:10.1016/0092-8674(88)90459-x · Cited by 357 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works
A Novel Reaction Mechanism for the Formation of S-Nitrosothiol in Vivo
Gow, A. J., Buerk, D. G., & Ischiropoulos, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2841 · Cited by 304 · see citing works
Red blood cell regulation of microvascular tone through adenosine triphosphate
Dietrich, H. H., Ellsworth, M. L., Sprague, R. S., & Dacey, R. G. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.4.h1294 · Cited by 278 · see citing works
Conformation, co-operativity and ligand binding in human hemoglobin
Cassoly, R., & Gibson, Q. H. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90382-4 · Cited by 259 · see citing works
The Reaction between Nitrite and Deoxyhemoglobin
Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., & Hogg, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501496200 · Cited by 253 · see citing works
Hemoglobin conformation couples erythrocyte S -nitrosothiol content to O 2 gradients
Doctor, A., Platt, R., Sheram, M. L., Eischeid, A. C., McMahon, T., Maxey, T., Doherty, J., Axelrod, M. J., Kline, J. M., Gurka, M. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407490102 · Cited by 205 · see citing works
Luchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202 · see citing works
Self-citationKim‐Shapiro, D. B., Gladwin, M. T., Patel, R. P., & Hogg, N. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.10.034 · Cited by 172 · see citing works
Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin
McMahon, T., Stone, A. E., Bonaventura, J., Singel, D. J., & Stamler, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000532200 · Cited by 140 · see citing works
Self-citationImpaired vasodilation by red blood cells in sickle cell disease
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409876102 · Cited by 137 · see citing works
Self-citationMcMahon, T., Ahearn, G. S., Moya, M. M., Gow, A. J., Huang, Y.-C. T., Luchsinger, B. P., Nudelman, R., Yan, Y., Krichman, A. D., Bashore, T. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506957102 · Cited by 130 · see citing works
Self-citationReactions of Deoxy-, Oxy-, and Methemoglobin with Nitrogen Monoxide
Herold, S., & Röck, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210275200 · Cited by 99 · see citing works
Luchsinger, B. P., Rich, E. N., Yan, Y., Williams, E. M., Stamler, J. S., & Singel, D. J. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.12.010 · Cited by 89 · see citing works
Self-citationNagababu, E., Ramasamy, S., & Rifkind, J. M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.012 · Cited by 86 · see citing works
Autocatalytic oxidation of hemoglobin induced by nitrite: Activation and chemical inhibition
Doyle, M. P., Herman, J. G., & Dykstra, R. L. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90019-4 · Cited by 81 · see citing works
Fago, A., Crumbliss, A. L., Peterson, J., Pearce, L. L., & Bonaventura, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2032603100 · Cited by 40 · see citing works
Mechanistic studies of S-nitrosothiol formation by NO/O2 and by NO/methemoglobin
Herold, S., & Röck, G. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.02.013 · Cited by 38 · see citing works
Edelstein, S. J., & Gibson, W. H. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41878-4 · Cited by 37 · see citing works
Release of Nitric Oxide from S-Nitrosohemoglobin. Electron Transfer as a Response to Deoxygenation
Pezacki, J. P., Ship, N. J., & Kluger, R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja015716o · Cited by 36 · see citing works
Zhao, Y., & Houk, K. N. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057097f · Cited by 34 · see citing works
Structural effects in alkyl nitrite oxidation of human hemoglobin.
Doyle, M. P., PICKERING, R. A., & da Conceição, J. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43624-6 · Cited by 30 · see citing works
Holt, J. M., & Ackers, G. K. (2005) · Biochemistry · doi:10.1021/bi050710n · Cited by 11 · see citing works
Red Blood Cell-Mediated Hypoxic Vasodilatation
James, P. E., Tufnell-Barret, T., Milsom, A. B., Frenneaux, M. P., & Lang, D. (2004) · Circulation Research · doi:10.1161/res.95.2.e8 · Cited by 10 · see citing works
Rates of release of nitric oxide from HbSNO and internal electron transfer
Ship, N. J., Pezacki, J. P., & Kluger, R. (2003) · Bioorganic Chemistry · doi:10.1016/s0045-2068(02)00509-6 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [28]Fago, A., Crumbliss, A. L., Peterson, J., Pearce, L. L. & Bonaventura, C. (2003) Proc. Natl. Acad. Sci. USA 100, 12087-12092.
Cited by
Sorted by citations
Evolution of adverse changes in stored RBCs
Bennett‐Guerrero, E., Veldman, T. H., Doctor, A., Telen, M. J., Ortel, T. L., Reid, T. S., Mulherin, M. A., Zhu, H., Buck, R. D., Califf, R. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708160104 · Cited by 614 · see citing works
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Ingested nitrate and nitrite and stomach cancer risk: An updated review
Bryan, N. S., Alexander, D. D., Coughlin, J. R., Milkowski, A. L., & Boffetta, P. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.062 · Cited by 335 · see citing works
Chen, K., Pittman, R. N., & Popel, A. S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1959 · Cited by 325 · see citing works
Erythrocyte programmed cell death
Föller, M., Huber, S. M., & Lang, F. J. W. (2008) · IUBMB Life · doi:10.1002/iub.106 · Cited by 314 · see citing works
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling
Straub, A. C., Lohman, A. W., Billaud, M., Johnstone, S. R., Dwyer, S. T., Lee, M. Y., Bortz, P. S., Best, A. K., Columbus, L., Gaston, B., et al. (2012) · Nature · doi:10.1038/nature11626 · Cited by 308 · see citing works
Stomberski, C. T., Hess, D. T., & Stamler, J. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7403 · Cited by 292 · see citing works
Self-citationS -nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked blood
Reynolds, J. D. H., Ahearn, G. S., Angelo, M., Zhang, J., Cobb, F. R., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707958104 · Cited by 282 · see citing works
Self-citationLehnert, N., Kim, E., Dong, H. T., Harland, J. B., Hunt, A. P., Manickas, E. C., Oakley, K. M., Pham, J., Reed, G. C., & Alfaro, V. S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00253 · Cited by 277 · see citing works
Structure and function of haemoglobins
Gell, D. A. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.10.006 · Cited by 277 · see citing works
Discovery of the nitric oxide signaling pathway and targets for drug development
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3228 · Cited by 256 · see citing works
Eryptosis, a Window to Systemic Disease
Lang, F. J. W., Gulbins, E., Lerche, H., Huber, S. M., Kempe, D. S., & Föller, M. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185448 · Cited by 252 · see citing works
Jensen, F. B. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.023697 · Cited by 237 · see citing works
Petersson, J., Carlström, M., Schreiber, O., Phillipson, M., Christoffersson, G., Jägare, A., Roos, S., Jansson, E. Å., Persson, A. E. G., Lundberg, J. O., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.011 · Cited by 235 · see citing works
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin
Basu, S., Grubina, R., Huang, J., Conradie, J., Huang, Z., Jeffers, A., Jiang, A., He, X., Azarov, I., Seibert, R., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.46 · Cited by 224 · see citing works
Tissue Processing of Nitrite in Hypoxia
Feelisch, M., Fernandez, B. O., Bryan, N. S., Garcia-Saura, M. F., Bauer, S., Whitlock, D. R., Ford, P. C., Janero, D. R., Rodriguez, J., & Ashrafian, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806654200 · Cited by 218 · see citing works
Goodrich, L. E., Paulat, F., Praneeth, V. K. K., & Lehnert, N. (2010) · Inorganic Chemistry · doi:10.1021/ic902304a · Cited by 204 · see citing works
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works
Terpolilli, N. A., Kim, S.-W., Thal, S. C., Kataoka, H., Zeisig, V., Nitzsche, B., Klaesner, B., Zhu, C., Schwarzmaier, S. M., Meissner, L., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.253419 · Cited by 199 · see citing works
Gladwin, M. T., Grubina, R., & Doyle, M. P. (2009) · Accounts of Chemical Research · doi:10.1021/ar800089j · Cited by 194 · see citing works
Diversity of Globin Function: Enzymatic, Transport, Storage, and Sensing
Vinogradov, S. N., & Moens, L. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700029200 · Cited by 194 · see citing works
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184 · see citing works
Stokes, K. Y., Dugas, T. R., Tang, Y., Garg, H., Guidry, E., & Bryan, N. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2008 · Cited by 171 · see citing works
Suicide for Survival - Death of Infected Erythrocytes as a Host Mechanism to Survive Malaria
Föller, M., Bobbala, D., Koka, S., Huber, S. M., Gulbins, E., & Lang, F. J. W. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000233238 · Cited by 170 · see citing works
Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation
Allen, B. W., Stamler, J. S., & Piantadosi, C. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.002 · Cited by 165 · see citing works
Self-citationErythrocytes and Vascular Function: Oxygen and Nitric Oxide
Helms, C. C., Gladwin, M. T., & Kim‐Shapiro, D. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00125 · Cited by 166 · see citing works
A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation
Seth, D., Hess, D. T., Hausladen, A., Wang, L., Wang, Y., & Stamler, J. S. (2018) · Molecular Cell · doi:10.1016/j.molcel.2017.12.025 · Cited by 160 · see citing works
Self-citationMechanisms of nitrite bioactivation
Kim-Shapiro, D. B., & Gladwin, M. T. (2014) · Nitric Oxide · doi:10.1016/j.niox.2013.11.002 · Cited by 157 · see citing works
Sodium nitrite: The “cure” for nitric oxide insufficiency
Parthasarathy, D. K., & Bryan, N. S. (2012) · Meat Science · doi:10.1016/j.meatsci.2012.03.001 · Cited by 157 · see citing works
Yang, J., Gonon, A. T., Sjöquist, P.-O., Lundberg, J. O., & Pernow, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307058110 · Cited by 147 · see citing works
Hypoxic Vasodilation by Red Blood Cells
Diesen, D. L., Hess, D. T., & Stamler, J. S. (2008) · Circulation Research · doi:10.1161/circresaha.108.176867 · Cited by 145 · see citing works
Self-citationGrubina, R., Huang, Z., Shiva, S., Joshi, M. S., Azarov, I., Basu, S., Ringwood, L. A., Jiang, A., Hogg, N., Kim‐Shapiro, D. B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700546200 · Cited by 147 · see citing works
Hemoglobin-mediated nitric oxide signaling
Helms, C., & Kim-Shapiro, D. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.028 · Cited by 146 · see citing works
Nitric oxide in adaptation to altitude
Beall, C. M., Laskowski, D. M., & ERZURUM, S. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.028 · Cited by 146 · see citing works
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works
Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions
Petersen, M. G., Dewilde, S., & Fago, A. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.05.008 · Cited by 144 · see citing works
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
Bryan, N. S., Tribble, G., & Angelov, N. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0725-2 · Cited by 137 · see citing works
Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology
Premont, R. T., Reynolds, J. D. H., Zhang, R., & Stamler, J. S. (2019) · Circulation Research · doi:10.1161/circresaha.119.315626 · Cited by 142 · see citing works
Self-citationS-Nitrosylation of Cardiac Ion Channels
González, D. R., Treuer, A. V., Sun, Q.-A., Stamler, J. S., & Hare, J. M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181b72c9f · Cited by 137 · see citing works
Self-citationAnemia and splenomegaly in cGKI-deficient mice
Föller, M., Feil, S., Ghoreschi, K., Koka, S., Gerling, A., Thunemann, M., Hofmann, F., Schuler, B., Vogel, J., Pichler, B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708940105 · Cited by 136 · see citing works
Milkowski, A., Garg, H. K., Coughlin, J. R., & Bryan, N. S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.08.004 · Cited by 123 · see citing works
S-Nitrosothiol measurements in biological systems
Gow, A. J., Doctor, A., Mannick, J. B., & Gaston, B. M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.01.052 · Cited by 122 · see citing works
Minetti, M., Agati, L., & Malorni, W. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.007 · Cited by 116 · see citing works
A Genetic Analysis of Nitrosative Stress
Foster, M. W., Liu, L., Zeng, M., Hess, D. T., & Stamler, J. S. (2009) · Biochemistry · doi:10.1021/bi801813n · Cited by 112 · see citing works
Self-citationA protein microarray-based analysis of S -nitrosylation
Foster, M. W., Forrester, M. T., & Stamler, J. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900729106 · Cited by 111 · see citing works
Self-citationWang, X., Kettenhofen, N. J., Shiva, S., Hogg, N., & Gladwin, M. T. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.032 · Cited by 111 · see citing works
Anoxic nitric oxide cycling in plants: participating reactions and possible mechanisms
Igamberdiev, A. U., Bykova, N. V., Shah, J. K., & Hill, R. D. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01314.x · Cited by 110 · see citing works
Dietary nitrite improves insulin signaling through GLUT4 translocation
Jiang, H., Torregrossa, A. C., Potts, A., Pierini, D., Aranke, M., Garg, H. K., & Bryan, N. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.809 · Cited by 105 · see citing works
Neuroglobin, seven years after
Brunori, M., & Vallone, B. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7090-2 · Cited by 105 · see citing works
Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1
Jordan, B. F., & Sonveaux, P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00094 · Cited by 104 · see citing works
Nitric oxide delivery to cancer: Why and how?
Sonveaux, P., Jordan, B. F., Gallez, B., & Féron, O. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.12.018 · Cited by 99 · see citing works
Assessment of nitric oxide signals by triiodide chemiluminescence
Hausladen, A., Rafikov, R., Angelo, M., Singel, D. J., Nudler, E., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611191104 · Cited by 99 · see citing works
Self-citationS-Nitrosylation signaling regulates cellular protein interactions
Marozkina, N. V., & Gaston, B. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.06.017 · Cited by 98 · see citing works
Zhu, S.-G., Kukreja, R. C., Das, A., Chen, Q., Lesnefsky, E. J., & Xi, L. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.024 · Cited by 96 · see citing works
How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm
Allen, B. W., & Piantadosi, C. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00310.2006 · Cited by 90 · see citing works
Effect of Processing and Storage on Red Blood Cell Function In Vivo
Doctor, A., & Spinella, P. C. (2012) · Seminars in Perinatology · doi:10.1053/j.semperi.2012.04.005 · Cited by 80 · see citing works
Ingram, T. E., Pinder, A. G., Bailey, D. M., Fraser, A. G., & James, P. E. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00583.2009 · Cited by 78 · see citing works
Nitric oxide deficiency is a primary driver of hypertension
Bryan, N. S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115325 · Cited by 77 · see citing works
Mechanisms of Human Erythrocytic Bioactivation of Nitrite
Liu, C., Wajih, N., Liu, X., Basu, S., Janes, J., Marvel, M., Keggi, C., Helms, C. C., Lee, A. N., Belanger, A. M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609222 · Cited by 76 · see citing works
Cardiovascular and renal effects of chronic exposure to high altitude
Hurtado, A., Escudero, E., Pando, J., Sharma, S., & Johnson, R. J. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs427 · Cited by 75 · see citing works
Nitric Oxide Transport in Blood: A Third Gas in the Respiratory Cycle
Doctor, A., & Stamler, J. S. (2011) · Comprehensive physiology · doi:10.1002/cphy.c090009 · Cited by 77 · see citing works
Self-citationInteractions of NO with Hemoglobin: From Microbes to Man
Angelo, M., Hausladen, A., Singel, D. J., & Stamler, J. S. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)36008-x · Cited by 73 · see citing works
Self-citationMolecular Controls of the Oxygenation and Redox Reactions of Hemoglobin
Bonaventura, C., Henkens, R. W., Alayash, A. I., Banerjee, S., & Crumbliss, A. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4947 · Cited by 70 · see citing works
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
Patel, R. P., Hogg, N., & Kim-Shapiro, D. B. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq323 · Cited by 70 · see citing works
Sonveaux, P., Lobysheva, I. I., Féron, O., & McMahon, T. J. (2007) · Physiology · doi:10.1152/physiol.00042.2006 · Cited by 70 · see citing works
Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
Tsoukias, N. M. (2008) · Microcirculation · doi:10.1080/10739680802010070 · Cited by 65 · see citing works
Pinder, A. G., Pittaway, E., Morris, K., & James, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00340.x · Cited by 66 · see citing works
Reactive Nitrogen Species Reactivities with Nitrones: Theoretical and Experimental Studies
Nash, K. M., Rockenbauer, A., & Villamena, F. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200526y · Cited by 68 · see citing works
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
Vitturi, D. A., Teng, X., Toledo, J. C., Matalon, S., Lancaster, J. R., & Patel, R. P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01303.2008 · Cited by 62 · see citing works
Oxygen Atom Transfer from Nitrite Mediated by Fe(III) Porphyrins in Aqueous Solution
Khin, C., Heinecke, J. L., & Ford, P. C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja804520y · Cited by 61 · see citing works
Proteomic methods for analysis of S-nitrosation
Kettenhofen, N. J., Broniowska, K. A., Keszler, Á., Zhang, Y., & Hogg, N. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.035 · Cited by 60 · see citing works
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation
Bailey, J., Feelisch, M., Horowitz, J. D., Frenneaux, M. P., & Madhani, M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.009 · Cited by 60 · see citing works
Mechanisms impairing blood pressure responses to nitrite and nitrate
Oliveira‐Paula, G. H., Pinheiro, L. C., & Tanus-Santos, J. E. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.01.015 · Cited by 60 · see citing works
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
The dichotomous role of H2S in cancer cell biology? Déjà vu all over again
Kashfi, K. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.042 · Cited by 59 · see citing works
Quantification of intermediates formed during the reduction of nitrite by deoxyhemoglobin
Salgado, M. T., Nagababu, E., & Rifkind, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808647200 · Cited by 56 · see citing works
Nitrogen Chemistry and Lung Physiology
Marozkina, N. V., & Gaston, B. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170352 · Cited by 57 · see citing works
Inactivation of Soluble Guanylate Cyclase by Stoichiometric S-Nitrosation
Mayer, B., Kleschyov, A. L., Stessel, H., Russwurm, M., Münzel, T. F., Koesling, D., & Schmidt, K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.052142 · Cited by 55 · see citing works
Ibrahim, Y., Ninnis, J. R., Hopper, A. O., Deming, D. D., Zhang, A. X., Herring, J. L., Sowers, L. C., McMahon, T., Power, G. G., & Blood, A. B. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.07.040 · Cited by 52 · see citing works
Nitric Oxide during Altitude Acclimatization
Janocha, A. J., Koch, C. D., Tiso, M., Ponchia, A., Doctor, A., Gibbons, L. B., Gaston, B. M., Beall, C. M., & ERZURUM, S. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1107887 · Cited by 51 · see citing works
Saijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M., Andry, C., Granger, D. N., Rodriguez, J., & Feelisch, M. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.009 · Cited by 51 · see citing works
Frérart, F., Sonveaux, P., Rath, G., Smoos, A., Meqor, A., Charlier, N., Jordan, B. F., Saliez, J., Noël, A., Dessy, C., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4001 · Cited by 49 · see citing works
Sun, C., Yang, J., Kleschyov, A. L., Zhuge, Z., Carlström, M., Pernow, J., Wajih, N., Isbell, T. S., Oh, J., Cabrales, P., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039284 · Cited by 47 · see citing works
Nitric oxide in red blood cell adaptation to hypoxia
Zhao, Y., Wang, X., Noviana, M., & Hou, M. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy055 · Cited by 46 · see citing works
Low NO Concentration Dependence of Reductive Nitrosylation Reaction of Hemoglobin
Tejero, J., Basu, S., Helms, C. C., Hogg, N., King, S. B., Kim‐Shapiro, D. B., & Gladwin, M. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.298927 · Cited by 43 · see citing works
Thiol redox biochemistry: insights from computer simulations
Zeida, A., Guardia, C. M. A., Lichtig, P., Perissinotti, L. L., Defelipe, L. A., Turjanski, A. G., Radí, R., Trujillo, M., & Estrin, D. A. (2014) · Biophysical Reviews · doi:10.1007/s12551-013-0127-x · Cited by 45 · see citing works
Cytochrome c-mediated formation of S-nitrosothiol in cells
Broniowska, K. A., Keszler, Á., Basu, S., Kim‐Shapiro, D. B., & Hogg, N. (2011) · Biochemical Journal · doi:10.1042/bj20111294 · Cited by 44 · see citing works
S-nitrosylation therapy to improve oxygen delivery of banked blood
Reynolds, J. D. H., Bennett, K. M., Cina, A. J., Diesen, D. L., Henderson, M. B., Matto, F., Plante, A., Williamson, R. A., Zandinejad, K., It, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306489110 · Cited by 41 · see citing works
Self-citationKurtikyan, T. S., & Ford, P. C. (2007) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2007.10.012 · Cited by 41 · see citing works
Nitric oxide production pathways in erythrocytes and plasma
Chen, K., & Popel, A. S. (2009) · Biorheology · doi:10.3233/bir-2009-0531 · Cited by 40 · see citing works
Nitrite Reductase Activity of Sol-Gel-encapsulated Deoxyhemoglobin
Roche, C. J., Dantsker, D., Samuni, U., & Friedman, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603914200 · Cited by 39 · see citing works
The transfusion problem: role of aberrant S‐nitrosylation
Reynolds, J. D. H., Hess, D. T., & Stamler, J. S. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03097.x · Cited by 37 · see citing works
Self-citationThe roles of S-nitrosylation and S-glutathionylation in Alzheimer's disease
Dyer, R. R., Ford, K. I., & Robinson, R. A. S. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.08.004 · Cited by 37 · see citing works
The role of globins in cardiovascular physiology
Keller, T. C. S., Lechauve, C., Keller, A., Brooks, S., Weiss, M. J., Columbus, L. M., Ackerman, H. C., Cortese-Krott, M. M., & Isakson, B. E. (2021) · Physiological Reviews · doi:10.1152/physrev.00037.2020 · Cited by 37 · see citing works
Cabrales, P., & Friedman, J. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5099.test · Cited by 37 · see citing works
Riego, J. A., Broniowska, K. A., Kettenhofen, N. J., & Hogg, N. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.027 · Cited by 37 · see citing works
Nitric Oxide Regulation of Microvascular Oxygen
Buerk, D. G. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1551 · Cited by 36 · see citing works
Gender Differences in S-Nitrosoglutathione Reductase Activity in the Lung
Brown-Steinke, K., deRonde, K. A., Yemen, S., & Palmer, L. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014007 · Cited by 35 · see citing works
- Authors
- Angelo, M., Singel, D. J., & Stamler, J. S.
- Affiliations
- Duke Medical Center (US)
- Montana State University (US)
- Duke University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-05-30
- Volume
- 103
- Issue
- 22
- Pages
- 8366-8371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989100763
- Cited by
- 233
- References
- 38
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 19
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Heart, Lung, and Blood Institute (P01HL042444, R01 HL42444)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- hemoglobin, S-nitrosohemoglobin, nitrite, nitric oxide, T state, allosteric transition, R state, erythrocytes, vasodilation, hypoxemia
- MeSH terms
- Hemoglobins, Humans, Iron, Nitrites, Oxygen, Spectrum Analysis, Substrate Specificity, S-Nitrosothiols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
