The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
Open accessAbstract
Significance: Identifying the source and dynamics of persistent HIV-1 during combinational antiretroviral therapy (cART) is crucial for understanding the barriers to curing HIV infection. Through genetic characterization of HIV-1 DNA in infected cells from peripheral blood and gut-associated lymphoid tissue from patients after long-term suppressive cART, our study reveals that the primary barrier to a cure is a remarkably stable pool of infected memory CD4 + T cells. Through in-depth phylogenetic analyses, we determined that the HIV-1 reservoir in these cells from eight patients is kept stable during long-term cART and, with little evidence of viral replication, this population could be maintained by homeostatic cell proliferation or other processes.
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Cites
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Bayesian Phylogenetics with BEAUti and the BEAST 1.7
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
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Cited by
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., et al. (2014) · Science · doi:10.1126/science.1254194 · Cited by 849
Self-citationHIV-1 Integration Landscape during Latent and Active Infection
Cohn, L. B., Silva, I. T., Oliveira, T. Y., Rosales, R. A., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J. L., McElrath, M. J., Lehmann, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.020 · Cited by 444
International AIDS Society global scientific strategy: towards an HIV cure 2016
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Self-citationImamichi, H., Dewar, R. L., Adelsberger, J. W., Rehm, C. A., O’Doherty, U., Paxinos, E. E., Fauci, A. S., & Lane, H. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609057113 · Cited by 344
Metadata
- Authors
- Josefsson, L., von Stockenstrom, S., Faria, N. R., Sinclair, E., Bacchetti, P., Killian, M., Epling, L., Tan, A., Ho, T., Lemey, P., Shao, W., Hunt, P. W., Somsouk, M., Wylie, W., Douek, D. C., Loeb, L., Custer, J., Hoh, R., Poole, L., Deeks, S. G., Hecht, F., & Palmer, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-25
- Volume
- 110
- Issue
- 51
- Pages
- E4987-96
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046159404
- Cited by
- 277
- References
- 58
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Josefsson, L., von Stockenstrom, S., Faria, N. R., Sinclair, E., Bacchetti, P., Killian, M., Epling, L., Tan, A., Ho, T., Lemey, P., Shao, W., Hunt, P. W., Somsouk, M., Wylie, W., Douek, D. C., Loeb, L., Custer, J., Hoh, R., Poole, L., . . . Palmer, S. (2013). The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1308313110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
