The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Open accessAbstract
HIV persists in a reservoir of latently infected CD4+ T cells in individuals treated with highly active antiretroviral therapy (HAART). Here we identify central memory (TCM) and transitional memory (TTM) CD4+ T cells as the major cellular reservoirs for HIV and find that viral persistence is ensured by two different mechanisms. HIV primarily persists in TCM cells in subjects showing reconstitution of the CD4+ compartment upon HAART. This reservoir is maintained through T cell survival and low-level antigen-driven proliferation and is slowly depleted with time. In contrast, proviral DNA is preferentially detected in TTM cells from aviremic individuals with low CD4+ counts and higher amounts of interleukin-7–mediated homeostatic proliferation, a mechanism that ensures the persistence of these cells. Our results suggest that viral eradication might be achieved through the combined use of strategic interventions targeting viral replication and, as in cancer, drugs that interfere with the self renewal and persistence of proliferating memory T cells.
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Cites
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Cited by
Human memory T cells: generation, compartmentalization and homeostasis
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Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
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A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
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Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
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Metadata
- Authors
- Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M.-R., Ghattas, G., Brenchley, J. M., Schacker, T. W., Hill, B. J., Douek, D. C., Routy, J.-P., Haddad, E. K., & Sékaly, R.-P.
- Venue
- Nature Medicine
- Published
- 2009-06-21
- Volume
- 15
- Issue
- 8
- Pages
- 893-900
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2124114936
- Cited by
- 1,722
- References
- 7
- FWCI
- 21.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. https://app.cochat.ai/papers/10.1038/nm.1972
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- Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M.-R., Ghattas, G., Brenchley, J. M., Schacker, T. W., Hill, B. J., Douek, D. C., Routy, J.-P., Haddad, E. K., & Sékaly, R.-P. (2009). HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nature Medicine. https://doi.org/10.1038/nm.1972
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