The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Efficient nonmeiotic allele introgression in livestock using custom endonucleases
Open accessAbstract
Significance: Selective breeding has long been practiced to enrich for desirable DNA variation that influences livestock traits. We demonstrate that genetic variants can be directly introgressed into livestock genomes using a modified transcription activator-like effector nuclease system. The transient exposure of livestock cells to sequence-targeted editors stimulates homology-directed repair to levels that eliminate the need for transgene-dependent selection. Use of oligonucleotide template enables efficient single nucleotide changes to the genome and permits the transmission of both natural and novel DNA sequence variants into naïve livestock breeds and species. Gene editing offers a powerful method for accelerating the genetic improvement of livestock for food and also for developing swine as a resource for regenerative medicine and models of human disease.
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Cites
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
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Double muscling in cattle due to mutations in the myostatin gene
McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039
TAL effectors: customizable proteins for DNA targeting
Bogdanove, A. J., & Voytas, D. F. (2011) · Science · doi:10.1126/science.1204094 · Cited by 984
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
Mussolino, C., Morbitzer, R., Lütge, F., Dannemann, N., Lahaye, T., & Cathomen, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr597 · Cited by 714
Gene targeting using zinc finger nucleases
Porteus, M. H., & Carroll, D. (2005) · Nature Biotechnology · doi:10.1038/nbt1125 · Cited by 641
Cited by
Genome Engineering with Targetable Nucleases
Carroll, D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035418 · Cited by 568
Estrada, J. L., Martens, G., Li, P., Adams, A., Newell, K. A., Ford, M. L., Butler, J. R., Sidner, R., Tector, M., & Tector, J. (2015) · Xenotransplantation · doi:10.1111/xen.12161 · Cited by 417
Crispo, M., Mulet, A. P., Tesson, L., Barrera, N., Cuadro, F., dos Santos-Neto, P. C., Nguyen, T. H., Crénéguy, A., Brusselle, L., Anegón, I., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136690 · Cited by 264
Genetically engineered pigs as models for human disease
Perleberg, C., Kind, A., & Schnieke, A. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.030783 · Cited by 222
Regulatory framework for gene editing and other new breeding techniques (NBTs) in Argentina
Whelan, A. I., & Lema, M. A. (2015) · GM Crops & Food · doi:10.1080/21645698.2015.1114698 · Cited by 192
Metadata
- Authors
- Tan, W., Carlson, D. F., Lancto, C. A., Garbe, J. R., Webster, D. A., Hackett, P. B., & Fahrenkrug, S. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-06
- Volume
- 110
- Issue
- 41
- Pages
- 16526-16531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157425075
- Cited by
- 278
- References
- 7
- FWCI
- 16.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tan, W., Carlson, D. F., Lancto, C. A., Garbe, J. R., Webster, D. A., Hackett, P. B., & Fahrenkrug, S. C. (2013). Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1310478110
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