Cited by 125Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyIron Metabolism and Disorders

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Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling

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Jones, Christopher M., Wells, Ryan M., Madduri, Ashoka V. R., Renfrow, Matthew B., Ratledge, Colin, Moody, D. Branch, Niederweis, Michael·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1311402111PMC PMC3918798

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Abstract

Significance: Many bacteria acquire iron from the environment by secreting small iron-binding molecules called siderophores. Mycobacterium tuberculosis , the causative agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin. Here, we demonstrate that M. tuberculosis recycles its siderophores to enable efficient iron use. Disrupting this process causes the intracellular accumulation of deferrated siderophores, which poisons M. tuberculosis. Both externally available and internally synthesized siderophores are toxic for the recycling-deficient mutant, despite its ability to use heme as an iron source. These findings suggest that targeting siderophore recycling may lead to the development of much-needed drugs to combat one of the world’s most deadly bacterial pathogens.

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Authors: Jones, C. M., Wells, R. M., Madduri, A. V. R., Renfrow, M. B., Ratledge, C., Moody, D. B., & Niederweis, M.
Affiliations: University of Alabama at Birmingham (US)
Brigham and Women's Hospital (US)
University of Hull (GB)
ORCID: Jones, Christopher M.
Renfrow, Matthew B.
Moody, D. Branch
Niederweis, Michael
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-01-13
Volume: 111
Issue: 5
Pages: 1945-1950
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1311402111
PMC: PMC3918798
OpenAlex: W1974201067
Cited by: 125
References: 47
Citations by year: 2026: 7 · 2025: 12 · 2024: 6 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 7 · 2018: 17 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 2
FWCI: 8.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Alabama at Birmingham (T32 GM008361)
University of Alabama
National Institutes of Health (AI074805)
Science and Technology Facilities Council (ST/H002235/1, PP/E00119X/1, ST/K001000/1)
National Institute of General Medical Sciences (T32GM008361)
National Institute of Allergy and Infectious Diseases (AI074805, T32 AI 07041, T32AI007493, P01AI074805, T32AI007041, R01AI083632, AI083632)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Mycobacterium tuberculosis, mycobactin, iron acquisition, antibiotic targets, tuberculosis
MeSH terms: Biological Transport, Genes, Bacterial, Iron, Models, Biological, Mutation, Mycobacterium tuberculosis, Oxazoles, Promoter Regions, Genetic, Salts, Siderophores, Intracellular Space

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Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling

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