The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling
Open accessAbstract
Significance: Many bacteria acquire iron from the environment by secreting small iron-binding molecules called siderophores. Mycobacterium tuberculosis , the causative agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin. Here, we demonstrate that M. tuberculosis recycles its siderophores to enable efficient iron use. Disrupting this process causes the intracellular accumulation of deferrated siderophores, which poisons M. tuberculosis. Both externally available and internally synthesized siderophores are toxic for the recycling-deficient mutant, despite its ability to use heme as an iron source. These findings suggest that targeting siderophore recycling may lead to the development of much-needed drugs to combat one of the world’s most deadly bacterial pathogens.
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“Recent evidence suggest that M. tuberculosis recycle siderophores to enable efficient iron use, whereas disruption of this process results in iron-mediated self-poisoning of the bacteria (209).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [209]
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Cites
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Siderophore-Based Iron Acquisition and Pathogen Control
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Chemistry and biology of siderophores
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Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
The architecture of respiratory complex I
Efremov, R. G., Baradaran, R., & Sazanov, L. A. (2010) · Nature · doi:10.1038/nature09066 · Cited by 634
Ojha, A. K., Baughn, A. D., Sambandan, D., Hsu, T., Trivelli, X., Guérardel, Y., Alahari, A., Kremer, L., Jacobs, W. R., & Hatfull, G. F. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06274.x · Cited by 562
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Cited by
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Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Bacterial siderophores in community and host interactions
Kramer, J., Özkaya, Ö., & Kümmerli, R. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0284-4 · Cited by 998
Hartkoorn, R. C., Uplekar, S. M., & Cole, S. T. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00037-14 · Cited by 493
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
Wilson, B., Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.10.005 · Cited by 479
Transition Metals and Virulence in Bacteria
Palmer, L. D., & Skaar, E. P. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035146 · Cited by 449
Metadata
- Authors
- Jones, C. M., Wells, R. M., Madduri, A. V. R., Renfrow, M. B., Ratledge, C., Moody, D. B., & Niederweis, M.
- Affiliations
- University of Alabama at Birmingham (US)
- Brigham and Women's Hospital (US)
- University of Hull (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 5
- Pages
- 1945-1950
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3918798
- OpenAlex
- W1974201067
- Cited by
- 125
- References
- 47
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 6 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 7 · 2018: 17 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 2
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Alabama at Birmingham (T32 GM008361)
- University of Alabama
- National Institutes of Health (AI074805)
- Science and Technology Facilities Council (ST/H002235/1, PP/E00119X/1, ST/K001000/1)
- National Institute of General Medical Sciences (T32GM008361)
- National Institute of Allergy and Infectious Diseases (AI074805, T32 AI 07041, T32AI007493, P01AI074805, T32AI007041, R01AI083632, AI083632)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Mycobacterium tuberculosis, mycobactin, iron acquisition, antibiotic targets, tuberculosis
- MeSH terms
- Biological Transport, Genes, Bacterial, Iron, Models, Biological, Mutation, Mycobacterium tuberculosis, Oxazoles, Promoter Regions, Genetic, Salts, Siderophores, Intracellular Space
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