The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration
Open accessAbstract
Significance: Heart failure is a term used to describe the heart’s inability to pump sufficient oxygen-rich blood throughout the body. This condition is commonly caused by the loss of heart muscle cells termed cardiomyocytes that results from a heart attack. As one of the least regenerative organs in the human body, the heart fails to regenerate damaged cardiomyocytes, forms a noncontractile scar instead, and progressively fails. Unlike mammals, adult zebrafish robustly regenerate their hearts following injury through division of uninjured cardiomyocytes, thus providing an opportunity to dissect innate cardiac regenerative mechanisms. Here, we provide evidence that Notch signaling is required for cardiomyocyte division and heart regeneration in zebrafish and, therefore, highlight a genetic determinant of natural heart renewal.
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1 retracted
RETRACTED: Notch1 regulates the fate of cardiac progenitor cells
Boni, A., Urbanek, K., Nascimbene, A., Hosoda, T., Zheng, H., Delucchi, F., Amano, K., Gonzalez, A., Vitale, S., Ojaimi, C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808357105 · Cited by 188
RetractedHeart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Heart Regeneration in Zebrafish
Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,932
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Self-citationZebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
Laflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,206
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans, T., MacRae, C. A., Stainier, D. Y. R., & Poss, K. D. (2010) · Nature · doi:10.1038/nature08804 · Cited by 1,054
Self-citationLepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 833
Self-citation
Cited by
Signaling pathways and targeted therapy for myocardial infarction
Zhang, Q., Wang, L., Wang, S., Cheng, H., Xu, L., Pei, G., Wang, Y., Fu, C., Jiang, Y., He, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00925-z · Cited by 831
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
The Role of the Epicardium During Heart Development and Repair
Quijada, P., Trembley, M. A., & Small, E. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315857 · Cited by 201
More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium
Dueñas, A., Aranega, A. E., & Franco, D. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00044 · Cited by 25
Metadata
- Authors
- Zhao, L., Borikova, A. L., Ben-Yair, R., Guner-Ataman, B., MacRae, C. A., Lee, R. T., Burns, C. G., & Burns, C. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 4
- Pages
- 1403-1408
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2118456141
- Cited by
- 255
- References
- 48
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. https://app.cochat.ai/papers/10.1073/pnas.1311705111
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- Zhao, L., Borikova, A. L., Ben-Yair, R., Guner-Ataman, B., MacRae, C. A., Lee, R. T., Burns, C. G., & Burns, C. E. (2014). Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1311705111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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