The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
Open accessAbstract
Although the protective cellular immune response to Mycobacterium tuberculosis requires recruitment of macrophages and T lymphocytes to the site of infection, the signals that regulate this trafficking have not been defined. We investigated the role of C-C chemokine receptor 2 (CCR2)-dependent cell recruitment in the protective response to M. tuberculosis. CCR2−/−mice died early after infection and had 100-fold more bacteria in their lungs than did CCR2+/+mice.CCR2−/−mice exhibited an early defect in macrophage recruitment to the lung and a later defect in recruitment of dendritic cells and T cells to the lung.CCR2−/−mice also had fewer macrophages and dendritic cells recruited to the mediastinal lymph node (MLN) after infection. T cell migration through the MLN was similar in CCR2−/−and CCR2+/+mice. However, T cell priming was delayed in the MLNs of the CCR2−/−mice, and fewer CD4+and CD8+T cells primed to produce IFN-γ accumulated in the lungs of the CCR2−/−mice. These data demonstrate that cellular responses mediated by activation of CCR2 are essential in the initial immune response and control of infection with M. tuberculosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410
Maini, R., St Clair, E. W., Breedveld, F., Furst, D., Kalden, J., Weisman, M., Smolen, J., Emery, P., Harriman, G., Feldmann, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)05246-0 · Cited by 2,345
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Self-citationFlynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schrelber, R., Mak, T. W., & Bloom, B. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90001-2 · Cited by 1,677
Self-citationMonocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.
Carr, M. W., Roth, S. J., Luther, E., Rose, S. S., & Springer, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3652 · Cited by 1,198
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S., & Lanzavecchia, A. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199809)28:09<2760::aid-immu2760>3.0.co;2-n · Cited by 1,183
Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119798 · Cited by 1,096
Self-citationThe Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.593 · Cited by 1,041
Lu, B., Rutledge, B. J., Gu, L., Fiorillo, J., Lukacs, N. W., Kunkel, S. L., North, R., Gerard, C., & Rollins, B. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.601 · Cited by 1,017
Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Muller, W. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80149-1 · Cited by 900
Cited by
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152
Self-citationMonocyte-Mediated Defense Against Microbial Pathogens
Serbina, N. V., Jia, T., Hohl, T. M., & Pamer, E. G. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090326 · Cited by 1,123
Dufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3195 · Cited by 1,075
Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection
Hohl, T. M., Rivera, A., Lipuma, L., Gallegos, A., Shi, C., Mack, M., & Pamer, E. G. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.10.007 · Cited by 337
Metadata
- Authors
- Peters, W., Scott, H. M., Chambers, H. F., Flynn, J. L., Charo, I. F., & Ernst, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-03
- Volume
- 98
- Issue
- 14
- Pages
- 7958-7963
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2128287837
- Cited by
- 331
- References
- 41
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. https://app.cochat.ai/papers/10.1073/pnas.131207398
- The paper
- Peters, W., Scott, H. M., Chambers, H. F., Flynn, J. L., Charo, I. F., & Ernst, J. D. (2001). Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.131207398
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
