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The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

Sallusto, Federica, Mackay, Charles R., Lanzavecchia, Antonio·2000·Annual Review of Immunology
DOI 10.1146/annurev.immunol.18.1.593
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Abstract

The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion. There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic and inflammatory conditions. The regulation of chemokine receptor expression during development and following cell activation explains the complex migratory pathways taken by dendritic cells, T and B lymphocytes, providing new insights into the mechanisms that control priming, effector function, and memory responses.

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Metadata

Authors
Sallusto, F., Mackay, C. R., & Lanzavecchia, A.
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2000-04
Volume
18
Issue
1
Pages
593-620
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev.immunol.18.1.593
OpenAlex
W2134486617
Cited by
1,041
References
9
FWCI
6.71
Type
journal article
Language
en
Open access
closed

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Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000). The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.18.1.593

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