MicroRNA-23a promotes myelination in the central nervous system
Open accessAbstract
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin.
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miR-23a can inhibit expression of lamin B1 to protect against leukodystrophy characterized by demyelination of the central nervous system.
“it can inhibit the expression of lamin B1 to protect against leukodystrophy characterized by demyelination of the central nervous system.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
The paper identifies lamin B1 as a target of miR-23a and links excess lamin B1 to leukodystrophy with central nervous system demyelination. However, the Discussion presents protection against demyelinating disease as a possible future therapeutic application, not a demonstrated effect of miR-23a. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLncRNA 2700046G09Rik was targeted by miR-23a to modulate PTEN and maintain normal myelin function.
“LncRNA 2700046G09Rik was targeted by miR-23a to modulate phosphatase and tensin homolog and maintain normal myelin function [133,134].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
Overexpressing miR-23a in mice was observed as the thickness of myelin increases.
“overexpressing miR-23a in mice was observed as the thickness of myelin increases”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
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Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262 · see citing works
Molecular Mechanisms of Long Noncoding RNAs
Wang, K., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.018 · Cited by 4,390 · see citing works
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,011 · see citing works
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791 · see citing works
Long Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721 · see citing works
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,128 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, É., Tavazoie, M. F., & Doetsch, F. K. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 976 · see citing works
Non-coding RNAs as regulators of embryogenesis
Pauli, A., Rinn, J. L., & Schier, A. F. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2904 · Cited by 623 · see citing works
Bace1 modulates myelination in the central and peripheral nervous system
Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608 · see citing works
Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., Lassmann, H., Wekerle, H., Hohlfeld, R., & Meinl, E. (2009) · Brain · doi:10.1093/brain/awp300 · Cited by 595 · see citing works
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
Kato, M. V., Putta, S., Wang, M., Yuan, H., Lanting, L. L., Nair, I., Gunn, A., Nakagawa, Y., Shimano, H., Todorov, I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1897 · Cited by 574 · see citing works
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.027 · Cited by 567 · see citing works
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
Qureshi, I., & Mehler, M. F. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3234 · Cited by 561 · see citing works
MicroRNAs: Novel Biomarkers for Human Cancer
Bartels, C. L., & Tsongalis, G. J. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112805 · Cited by 534 · see citing works
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q., Xin, M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.018 · Cited by 496 · see citing works
Lamin B1 duplications cause autosomal dominant leukodystrophy
Padiath, Q. S., Saigoh, K., Schiffmann, R., Asahara, H., Yamada, T., Koeppen, A. H., Hogan, K. J., Ptáček, L. J., & Fu, Y. (2006) · Nature Genetics · doi:10.1038/ng1872 · Cited by 407 · see citing works
Self-citationLong noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
Mercer, T. R., Qureshi, I., Gökhan, Ş., Dinger, M. E., Li, G., Mattick, J. S., & Mehler, M. F. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-14 · Cited by 394 · see citing works
Constitutively active Akt induces enhanced myelination in the CNS
Flores, A. I., Narayanan, S. P., Morse, E. N., Shick, H. E., Yin, X., Kidd, G., Avila, R. L., Kirschner, D. A., & Macklin, W. B. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0150-08.2008 · Cited by 361 · see citing works
Control of oligodendrocyte differentiation by theNkx2.2homeodomain transcription factor
Qi, Y. B., Cai, J., Wu, Y., Wu, R., Lee, J. D., Fu, H. Q., Rao, M. S., Sussel, L., Rubenstein, J. L. R., & Qiu, M. S. (2001) · Development · doi:10.1242/dev.128.14.2723 · Cited by 356 · see citing works
Goebbels, S., Oltrogge, J., Kemper, R., Heilmann, I., Bormuth, I., Wolfer, S., Wichert, S. P., Möbius, W., Liu, X., Lappe-Siefke, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0219-10.2010 · Cited by 329 · see citing works
Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination
Narayanan, S. P., Flores, A. I., Wang, F., & Macklin, W. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0232-09.2009 · Cited by 326 · see citing works
The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 263 · see citing works
Tyler, W. A., Gangoli, N., Gokina, P., Kim, H. A., Covey, M., Levison, S. W., & Wood, T. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0234-09.2009 · Cited by 263 · see citing works
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes
Lau, P., Verrier, J. D., Nielsen, J. A., Johnson, K. R., Notterpek, L. M., & Hudson, L. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1932-08.2008 · Cited by 254 · see citing works
miR-23regulation of lamin B1 is crucial for oligodendrocyte development and myelination
Lin, S., & Fu, Y. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001065 · Cited by 170 · see citing works
Self-citationOligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
Harrington, E. P., Zhao, C., Fancy, S. P. J., Kaing, S., Franklin, R. J. M., & Rowitch, D. H. (2010) · Annals of Neurology · doi:10.1002/ana.22090 · Cited by 159 · see citing works
Control of oligodendroglial cell number by the miR-17-92 cluster
Budde, H., Schmitt, S., Fitzner, D., Opitz, L., Salinas, G., & Simons, M. (2010) · Development · doi:10.1242/dev.050633 · Cited by 148 · see citing works
Decapping of Long Noncoding RNAs Regulates Inducible Genes
Geisler, S. J., Lojek, L. J., Khalil, A. M., Baker, K. E., & Coller, J. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.025 · Cited by 133 · see citing works
Tan, X., Wang, S., Zhu, L., Wu, C., Yin, B., Zhao, J., Yuan, J., Qiang, B., & Peng, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207787109 · Cited by 117 · see citing works
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
Goebbels, S., Oltrogge, J. H., Wolfer, S., Wieser, G. L., Nientiedt, T., Pieper, A. A., Ruhwedel, T., Groszer, M., Sereda, M. W., & Nave, K. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200227 · Cited by 111 · see citing works
Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
Ridolfi, E., Fenoglio, C., Cantoni, C., Calvi, A., Riz, M. A. D., Pietroboni, A. M., Villa, C., Serpente, M., Bonsi, R., Vercellino, M., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034375 · Cited by 89 · see citing works
β1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth
Barros, C. S., Nguyen, T., Spencer, K. S. R., Nishiyama, A., Colognato, H., & Müller, U. (2009) · Development · doi:10.1242/dev.038679 · Cited by 87 · see citing works
Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
Heng, M. Y., Lin, S.-T., Verret, L., Huang, Y., Kamiya, S., Padiath, Q. S., Tong, Y., Palop, J. J., Huang, E. J., Ptácχek, L. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66737 · Cited by 78 · see citing works
Self-citationPezzolesi, M. G., Zbuk, K. M., Waite, K. A., & Eng, C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm053 · Cited by 62 · see citing works
The transcriptional regulator Yin Yang 1 activates the myelin PLP gene
Berndt, J. A., Kim, J. G., Toŝić, M., Kim, C., & Hudson, L. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00307.x · Cited by 46 · see citing works
Unraveling Oligodendrocyte Origin and Function by Cell-Specific Transgenesis
Belachew, S. M., Yuan, X. Q., & Gallo, V. (2001) · Developmental Neuroscience · doi:10.1159/000048712 · Cited by 44 · see citing works
MicroRNAs are significantly influenced by p53 and radiation in HCT116 human colon carcinoma cells
An (2009) · International Journal of Oncology · doi:10.3892/ijo_00000295 · Cited by 40 · see citing works
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- Qi Y, et al. (2001) Control of oligodendrocyte differentiation by the Nkx2.2 homeo- domain transcription factor. Development 128(14):2723-2733.
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Sorted by citations
Liu, J., Fan, L., Yu, H., Zhang, J., He, Y., Feng, D., Wang, F., Li, X., Liu, Q., Li, Y., et al. (2019) · Hepatology · doi:10.1002/hep.30607 · Cited by 449 · see citing works
Emery, B., & Lu, Q. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020461 · Cited by 274 · see citing works
Molecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 294 · see citing works
MicroRNAs in neural development: from master regulators to fine-tuners
Rajman, M., & Schratt, G. M. (2017) · Development · doi:10.1242/dev.144337 · Cited by 258 · see citing works
Li, Y., Liu, Z., Song, Y., Pan, J.-J., Jiang, Y., Shi, X., Liu, C., Ma, Y., Luo, L., Mamtilahun, M., et al. (2022) · Theranostics · doi:10.7150/thno.68895 · Cited by 152 · see citing works
MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy
Dong, R., Liu, Y., Yang, Y., Wang, H., Xu, Y., & Zhang, Z. (2019) · BioMed Research International · doi:10.1155/2019/6458237 · Cited by 147 · see citing works
Giorgio, E., Robyr, D., Spielmann, M., Ferrero, E., Gregorio, E. D., Imperiale, D., Vaula, G., Stamoulis, G., Santoni, F. A., Atzori, C., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv065 · Cited by 146 · see citing works
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
Yang, H., Liu, P., Zhang, J., Xu, P., Lu, Z., Yu, S., Meng, Y., Tong, W.-M., & Chen, J. (2015) · Oncogene · doi:10.1038/onc.2015.430 · Cited by 139 · see citing works
From OPC to Oligodendrocyte: An Epigenetic Journey
Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D., & Vanmierlo, T. (2019) · Cells · doi:10.3390/cells8101236 · Cited by 121 · see citing works
microRNA and exosome profiling in multiple sclerosis
Mycko, M. P., & Baranzini, S. E. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458519879303 · Cited by 91 · see citing works
Li, T., Li, H., Wang, Y., Li, T., Fan, J., Xiao, K., Zhao, R. C., & Weng, X. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.01.004 · Cited by 64 · see citing works
Zheng, Y., Liu, L., Chen, C., Ming, P., Huang, Q., Li, C., Cao, D., Xu, X., & Ge, W. (2017) · PeerJ · doi:10.7717/peerj.3627 · Cited by 63 · see citing works
Epigenetic control of oligodendrocyte development: adding new players to old keepers
Liu, J., Moyon, S., Hernandez, M., & Casaccia, P. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.002 · Cited by 62 · see citing works
miRNAs As Emerging Regulators of Oligodendrocyte Development and Differentiation
Galloway, D. A., & Moore, C. S. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00059 · Cited by 59 · see citing works
Precocious myelination in a mouse model of autism
Khanbabaei, M., Hughes, E., Ellegood, J., Qiu, L. R., Yip, R., Dobry, J., Murari, K., Lerch, J. P., Rho, J. M., & Cheng, N. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0590-7 · Cited by 57 · see citing works
Li, J., Zhao, Y., Lu, Y., Ritchie, W., Grau, G., Vadas, M. A., & Gamble, J. R. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.62 · Cited by 55 · see citing works
Nuclear Lamins and Neurobiology
Young, S. G., Jung, H.-J., Lee, J. M., & Fong, L. G. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00486-14 · Cited by 52 · see citing works
Music-listening regulates human microRNA expression
Nair, P. S., Raijas, P., Ahvenainen, M., Philips, A. K., Ukkola‐Vuoti, L., & Järvelä, I. E. (2020) · Epigenetics · doi:10.1080/15592294.2020.1809853 · Cited by 53 · see citing works
Kurkewich, J. L., Hansen, J. M., Klopfenstein, N., Zhang, H., Wood, C., Boucher, A. C., Hickman, J. W., Muench, D. E., Grimes, H. L., & Dahl, R. E. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006887 · Cited by 49 · see citing works
The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy
Ponnusamy, V., & Yip, P. K. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.041 · Cited by 47 · see citing works
Small and Long Regulatory RNAs in the Immune System and Immune Diseases
Stachurska, A., Zorro, M. M., van der Sijde, M. R., & Withoff, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00513 · Cited by 47 · see citing works
Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Li, P., Teng, Z., & Liu, C. (2016) · Neural Plasticity · doi:10.1155/2016/1279051 · Cited by 46 · see citing works
Huang, Z., Chen, Y., Guo, H., & Chen, G. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.630876 · Cited by 47 · see citing works
Fath, M. K., Azami, J., Jaafari, N., Oryani, M. A., Jafari, N., poor, A. K., Azargoonjahromi, A., Nabi‐Afjadi, M., Payandeh, Z., Zalpoor, H., et al. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00377-x · Cited by 45 · see citing works
Azam, H. M. H., Rößling, R., Geithe, C., Khan, M. M., Dinter, F., Hanack, K., Prüß, H., Husse, B., Roggenbuck, D., Schierack, P., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1386735 · Cited by 45 · see citing works
MicroRNAs in oligodendrocyte development and remyelination
Ngo, C., & Kothary, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15618 · Cited by 38 · see citing works
Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair
Koreman, E., Sun, X., & Lu, Q. R. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.11.010 · Cited by 41 · see citing works
Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non-coding RNAs
Lin, S.-T., Heng, M. Y., Ptáček, L. J., & Fu, Y.-H. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-4 · Cited by 40 · see citing works
Self-citationGarbett, K. A., Vereczkei, A., Kalman, J. L., Wang, L., Korade, Ž., Shelton, R. C., & Mirnics, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.14 · Cited by 34 · see citing works
AAV9-mediated delivery of miR-23a reduces disease severity in Smn2B/−SMA model mice
Kaifer, K. A., Villalón, E., O’Brien, B. S., Sison, S. L., Smith, C. E., Simon, M. E., Marquez, J., O’Day, S., Hopkins, A. E., Neff, R., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz142 · Cited by 38 · see citing works
Liu, X., Fan, B. Y., Pan, W. L., Li, C., Levin, A. M., Wang, X., Zhang, R. L., Zervos, T. M., Hu, J., Zhang, X. M., et al. (2016) · RNA Biology · doi:10.1080/15476286.2016.1196320 · Cited by 37 · see citing works
MicroRNAs and their potential therapeutic applications in neural tissue engineering
Nguyen, L. H., Diao, H. J., & Chew, S. Y. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.007 · Cited by 36 · see citing works
MicroRNA and transcriptional crosstalk in myelinating glia
Svaren, J. P. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.06.010 · Cited by 33 · see citing works
Samudyata, S., Castelo‐Branco, G., & Liu, J. (2020) · Glia · doi:10.1002/glia.23820 · Cited by 31 · see citing works
MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology
Teuber‐Hanselmann, S., Meinl, E., & Junker, A. (2020) · The Journal of Pathology · doi:10.1002/path.5399 · Cited by 32 · see citing works
MicroRNA: Key regulators of oligodendrocyte development and pathobiology
Fitzpatrick, J.-M., Anderson, R. C., & McDermott, K. W. G. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.021 · Cited by 31 · see citing works
Geoffroy, A., Cherif, L. S., Pourié, G., Helle, D., Umoret, R., Guéant, J., Bossenmeyer‐Pourié, C., & Daval, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040973 · Cited by 29 · see citing works
Yang, X., Tian, S., Fan, L.-L., Niu, R., Yan, M., Chen, S., Zheng, M., & Zhang, S.-W. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02598-8 · Cited by 26 · see citing works
Liang, T., Yu, J., Liu, C., & Guo, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106223 · Cited by 28 · see citing works
Remyelination in multiple sclerosis from the miRNA perspective
Maciak, K., Dziedzic, A., & Saluk, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1199313 · Cited by 28 · see citing works
MicroRNAs and Regeneration in Animal Models of CNS Disorders
Roitbak, T. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02777-6 · Cited by 28 · see citing works
Qin, D., Wang, C., Li, D., & Guo, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105487 · Cited by 27 · see citing works
A critical role for miR-184 in the fate determination of oligodendrocytes
Afrang, N., Tavakoli, R., Tasharrofi, N., Alian, A., Sohi, A. N., Kabiri, M., Fathi‐Roudsari, M., Zomorrod, M. S., Rajaei, F., Soleimani, M., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1208-y · Cited by 27 · see citing works
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness
Sferra, A., Fortugno, P., Motta, M., Aiello, C., Petrini, S., Ciolfi, A., Cipressa, F., Moroni, I., Leuzzi, V., Pieroni, L., et al. (2021) · Brain · doi:10.1093/brain/awab185 · Cited by 26 · see citing works
Nejad, A. E., Zadeh, S. M. M., Nickho, H., Abbasian, A. S., Forouzan, A., Ahmadlou, M., Nedaeinia, R., Shaverdi, S., & Manian, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281567 · Cited by 26 · see citing works
Zailaie, S. A., Siddiqui, J. J., Saadi, R. M. A., Anbari, D. M., Alomari, A. S., & Cupler, E. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1887888 · Cited by 24 · see citing works
Moyon, S., Liang, J., & Casaccia, P. (2015) · Brain Research · doi:10.1016/j.brainres.2015.06.009 · Cited by 24 · see citing works
MicroRNAs change the games in central nervous system pharmacology
Marangon, D., Raffaele, S., Fumagalli, M., & Lecca, D. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.019 · Cited by 22 · see citing works
Zhu, X., Zhang, A., Dong, J., Yao, Y., Zhu, M., Xu, K., & Hamda, M. H. A. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.021 · Cited by 22 · see citing works
Inhibitory milieu at the multiple sclerosis lesion site and the challenges for remyelination
Galloway, D. A., Gowing, E., Setayeshgar, S., & Kothary, R. (2019) · Glia · doi:10.1002/glia.23711 · Cited by 22 · see citing works
MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies
Frankel, D., Delecourt, V., Harhouri, K., Sandre‐Giovannoli, A. D., Lévy, N., Kaspi, É., & Roll, P. (2018) · Aging Cell · doi:10.1111/acel.12766 · Cited by 21 · see citing works
S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement
Santos, G., Barateiro, A. P., Brites, D. M. T. O., & Fernandes, A. M. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00279 · Cited by 20 · see citing works
MicroRNAs and target genes in epileptogenesis
Feng, Y., Yang, H., Yue, Y., & Tian, F. (2020) · Epilepsia · doi:10.1111/epi.16687 · Cited by 20 · see citing works
Zhang, S., An, X., Huang, S., Zeng, L., Xu, Y., Su, D., Qu, Y., Tang, X., Ma, J., Yang, J., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.02.015 · Cited by 20 · see citing works
The epigenetic landscape of oligodendrocyte lineage cells
Selcen, I., Prentice, E., & Casaccia, P. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14959 · Cited by 20 · see citing works
Takamori, Y., Hirahara, Y., Wakabayashi, T., Mori, T., Koike, T., Kataoka, Y., Tamura, Y., Kurebayashi, S., Kurokawa, K., & Yamada, H. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.11.001 · Cited by 19 · see citing works
The Nuclear Envelope: An Intriguing Focal Point for Neurogenetic Disease
Worman, H. J., & Dauer, W. T. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0296-8 · Cited by 18 · see citing works
Epigenetic regulation of myelination in health and disease
Lu, G., Zhang, M., Wang, J., Zhang, K., Wu, S., & Zhao, X. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14337 · Cited by 16 · see citing works
MicroRNAs participate in the regulation of oligodendrocytes development in white matter injury
Xiao, D., Qu, Y., Pan, L., Li, X., & Mu, D. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0019 · Cited by 17 · see citing works
MicroRNA-23a-3p inhibitor decreases osteonecrosis incidence in a rat model
Dong, Y., Li, T., Li, Y., Ren, S., Fan, J., & Weng, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7808 · Cited by 17 · see citing works
Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination
Pruvost, M., & Moyon, S. (2021) · Life · doi:10.3390/life11010062 · Cited by 17 · see citing works
Response of plasma microRNAs to nusinersen treatment in patients with SMA
Zaharieva, I. T., Scoto, M., Aragon‐Gawinska, K., Ridout, D. A., Doreste, B., Servais, L., Francesco Muntoni, A., & Zhou, H. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51579 · Cited by 16 · see citing works
Do lamin B1 and lamin B2 have redundant functions?
Lee, J. M., Jung, H.-J., Fong, L. G., & Young, S. G. (2014) · Nucleus · doi:10.4161/nucl.29615 · Cited by 16 · see citing works
microRNAs in Autism Spectrum Disorders
Vasu, M. M., Sumitha, P. S., Parakkal, R., Thanseem, I., & Anitha, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105120901 · Cited by 15 · see citing works
Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches
Rashid, S., & Dimitriadi, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1307636 · Cited by 15 · see citing works
Ma, Q., Matsunaga, A., Ho, B., Oksenberg, J. R., & Didonna, A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01964-5 · Cited by 14 · see citing works
Gastrodin promotes CNS myelination via a lncRNA Gm7237/miR-142a/MRF pathway
Shu, Y. L., Luo, T., Wang, M., Zhang, Y., Zhang, L., Xiao, Z., Wang, Q., Zhang, Q., Zou, J., Yu, C., et al. (2020) · RNA Biology · doi:10.1080/15476286.2020.1841976 · Cited by 13 · see citing works
Self-citationHe, X., Ao, Q., Wei, Y., & Song, J. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12427 · Cited by 13 · see citing works
Epigenetic Regulation of the Hippocampus, with Special Reference to Radiation Exposure
Saw, G., & Tang, F. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249514 · Cited by 12 · see citing works
microRNA‑23 inhibits inflammation to alleviate rheumatoid arthritis via regulating CXCL12
Gao, B., Sun, G., Wang, Y., Geng, Y., Zhou, L., & Chen, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9890 · Cited by 12 · see citing works
Qiu, S., Dai, H., Wang, Y., Lv, Y., Yu, B., & Yao, C. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1404463 · Cited by 11 · see citing works
The role of transcriptional control in multiple system atrophy
Chen, J., Mills, J. D., Halliday, G. M., & Janitz, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.015 · Cited by 11 · see citing works
Zhu, X., Yao, Y., Liu, Y., Zhou, R., Zhang, W., Hu, Q., Liu, H., Hamda, M. H. A., & Zhang, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00180 · Cited by 11 · see citing works
Krattli, R. P., Markarian, M., Madan, S., Swami, D., McQuade, A., Baulch, J. E., Blurton-Jones, M. M., & Acharya, M. M. (2025) · Aging Cell · doi:10.1111/acel.70341 · Cited by 10 · see citing works
Soy glyceollins regulate transcript abundance in the female mouse brain
Bamji, S. F., Page, R. B., Patel, D., Sanders, A., Alvarez, A. R., Gambrell, C., Naik, K., Raghavan, A. M., Burow, M. E., Boué, S. M., et al. (2015) · Functional & Integrative Genomics · doi:10.1007/s10142-015-0442-3 · Cited by 10 · see citing works
Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases
Chen, Y., Sun, J., Tao, J., & Sun, T. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1322486 · Cited by 12 · see citing works
Łuczkowska, K., Rogińska, D., Ulańczyk, Z., Safranow, K., Paczkowska, E., Baumert, B., Milczarek, S., Osękowska, B., Górska, M., Borowiecka, E., et al. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1933478 · Cited by 9 · see citing works
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy
Hinman, J. D., Ngo, K. J., Kim, D., Chen, C.-D., Abraham, C. R., Ghanbari, M., Ikram, M. A., Kushner, S. A., Kawaguchi, R., Coppola, G., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa252 · Cited by 10 · see citing works
The Emerging Impact of microRNAs in Neurotrauma Pathophysiology and Therapy
Bhalala, O. G. (2015) · Europe PMC (PubMed Central) · Cited by 8 · see citing works
Enders, M., Weier, A., Chunder, R., An, Y., Bremm, F., Feigenspan, A., Buettner, C., Ekici, A. B., Mingardo, E., Odermatt, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043716 · Cited by 7 · see citing works
Identification and characterization of key long non-coding RNAs in the mouse cochlea
Koffler-Brill, T., Taiber, S., Anaya, A., Bordeynik‐Cohen, M., Rosen, E., Kolla, L., Messika-Gold, N., Elkon, R., Kelley, M. W., Ulitsky, I., et al. (2020) · RNA Biology · doi:10.1080/15476286.2020.1836456 · Cited by 7 · see citing works
Long Noncoding RNAs in CNS Myelination and Disease
Zhang, J., Guan, M.-L., Zhou, X., Berry, K., He, X.-L., & Lu, Q. R. (2022) · The Neuroscientist · doi:10.1177/10738584221083919 · Cited by 6 · see citing works
Functions of noncoding RNAs in glial development
Wu, J., Yu, H., Huang, H., Shu, P., & Peng, X. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22848 · Cited by 6 · see citing works
Leavy, A., Brennan, G. P., & Jimenez-Mateos, E. M. (2022) · Biomedicines · doi:10.3390/biomedicines10112740 · Cited by 6 · see citing works
Mir-23a inhibition attenuates ischemic/reperfusion-induced myocardial apoptosis by targeting XIAP.
Cheng, Y., Zhang, R., Yang, G., Zhang, Y., Li, C., Zhang, M., & Dai, Y. (2017) · PubMed Central · Cited by 6 · see citing works
Music-listening regulates human microRNA transcriptomePreprint
Nair, P. S., Raijas, P., Ahvenainen, M., Philips, A. K., Ukkola‐Vuoti, L., & Järvelä, I. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/599217 · Cited by 6 · see citing works
Recent advances of miR-23 in human diseases and growth development
Qian, X., Jiang, Y., Yang, Y., Zhang, Y., Xu, N., Xu, B., Pei, K., Yu, Z., & Wu, W. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.12.010 · Cited by 5 · see citing works
Shanthi, K., Fischer, D., Sharma, A., Kiviniemi, A., Kaakinen, M., Vainio, S., & Bart, G. (2023) · Genes · doi:10.3390/genes14040853 · Cited by 5 · see citing works
Zuo, Z., Zhou, H., & Zhou, J. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190717112944 · Cited by 6 · see citing works
Fan, Q., Song, X., Li, M., Xu, Q., Yan, C., Li, H., & Qu, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113735 · Cited by 4 · see citing works
Ishibashi, S., Kamei, N., Tsuchikawa, Y., Nakamae, T., Akimoto, T., Miyaki, S., & Adachi, N. (2024) · Genes · doi:10.3390/genes15040402 · Cited by 4 · see citing works
Tsuchikawa, Y., Kamei, N., Sanada, Y., Nakamae, T., Harada, T., Imaizumi, K., Akimoto, T., Miyaki, S., & Adachi, N. (2023) · Neural Plasticity · doi:10.1155/2023/8938674 · Cited by 4 · see citing works
Chen, B.-Y., Lin, J.-J., Tseng, H.-H., Huang, C.-C., Chen, P.-S., Li, C.-H., Yao, C.-Y., Wang, T.-Y., Jang, F.-L., & Lin, S.-H. (2025) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111543 · Cited by 2 · see citing works
Self-citationVerma, S., Mishra, R., Malik, A., Chaudhary, P., Malhotra, S. S., Panda, A. K., & Sk, G. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13409 · Cited by 3 · see citing works
Signaling pathways that regulate glial development and early migration—oligodendrocytes
Fancy, S. P. J., & Miller, R. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00035-7 · Cited by 2 · see citing works
Liu, C. (2024) · International Journal of Clinical and Experimental Pathology · doi:10.62347/mnsq2960 · Cited by 2 · see citing works
Xiong, H., Ma, Z., Li, G., Niu, Z., Yang, L., Wu, X., Wang, L., Xie, F., Vong, C. T., Sun, X., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01112 · Cited by 1 · see citing works
Shao, Q., Li, Z., Tan, W., Pu, Y., Sun, D., FANG, X., Shi, X., Zhang, X., Liu, W., Liu, M., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adu6987 · Cited by 1 · see citing works
Liu, T., Ren, Y., Lin, J., & Wei, J. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.07.008 · Cited by 1 · see citing works
- Authors
- Lin, S.-T., Huang, Y., Zhang, L., Heng, M. Y., Ptáček, L. J., & Fu, Y.-H.
- Affiliations
- Department of Neurology and
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-10-07
- Volume
- 110
- Issue
- 43
- Pages
- 17468-17473
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3808585
- OpenAlex
- W2071512787
- Cited by
- 117
- References
- 39
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 13 · 2019: 20 · 2018: 3 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 8
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063720)
- National Institute of Neurological Disorders and Stroke (NS062733, R01NS062733)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- microRNA-23a, myelination, oligodendrocyte differentiation, lamin B1, leukodystrophy, demyelination, myelin synthesis, microRNA target regulation, central nervous system
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Central Nervous System, Humans, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Myelin Sheath, Oligodendroglia, Blotting, Western, Signal Transduction, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase, Mice, HEK293 Cells, TOR Serine-Threonine Kinases, Transcriptome, RNA, Long Noncoding
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