The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Bet-hedging during bacterial diauxic shift
Open accessAbstract
Significance: More than 70 years ago, Monod described the phenomenon of diauxic growth of bacteria, the observation that in the presence of two alternative sugars, cells first use one of them and then, after a short lag phase, switch to the other. Until now it had been assumed that all cells in a population engage in the outgrowth on the second sugar after major metabolic adaptation of enzymatic composition has occurred, which takes time (hence the lag phase in growth). Here, we show that actually only a subpopulation is fit enough to partake in the second growth phase and present an evolutionary model, suggesting that this phenomenon might entail a bet-hedging strategy that helps bacteria adapt to the unexpectedly changing environment.
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Citations
Cites
1 retracted
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Stochastic Gene Expression in a Single Cell
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THE GROWTH OF BACTERIAL CULTURES
Monod, J. (1949) · Annual Review of Microbiology · doi:10.1146/annurev.mi.03.100149.002103 · Cited by 3,707
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952
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Raj, A., & van Oudenaarden, A. (2008) · Cell · doi:10.1016/j.cell.2008.09.050 · Cited by 2,593
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
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Phenotypic Diversity, Population Growth, and Information in Fluctuating Environments
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Cited by
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Self-citationAssessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance
Zheng, M., Zhang, R., Tian, X., Zhou, X., Pan, X., & Wong, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00908 · Cited by 218
Molecular and cellular bases of adaptation to a changing environment in microorganisms
Bleuven, C., & Landry, C. R. (2016) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2016.1458 · Cited by 104
Systems Biology of Lactic Acid Bacteria: For Food and Thought
Teusink, B., & Molenaar, D. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.07.005 · Cited by 95
Self-citation(2025) · doi:10.1128/msystems.00690-25 · Cited by 7
Metadata
- Authors
- Solopova, A., van Gestel, J., Weissing, F. J., Bachmann, H., Teusink, B., Kok, J., & Kuipers, O. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-05-05
- Volume
- 111
- Issue
- 20
- Pages
- 7427-7432
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109242001
- Cited by
- 256
- References
- 54
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Solopova, A., van Gestel, J., Weissing, F. J., Bachmann, H., Teusink, B., Kok, J., & Kuipers, O. P. (2014). Bet-hedging during bacterial diauxic shift. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1320063111
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
