The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD)
Open accessAbstract
Significance: The surface presentation of peptides by human leukocyte antigen (HLA) class I molecules is essential for adaptive immune responses against pathogens and tumors. To date, the repertoire of HLA class I peptides remains largely unexplored, although their identity could lead to new targets for vaccine development or cancer immunotherapy. Here, we demonstrate that recent developments in mass spectrometry (MS)-based sequencing technology can expand the detectable peptide repertoire to an unprecedented depth, revealing unique features in the antigen presentation machinery. Our data include a variety of posttranslational modifications for which evidence is accumulating that they play important roles in human diseases. Hence, next-generation MS-based sequencing can make the important step into the discovery of disease-related HLA class I antigens.
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Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925
Semi-supervised learning for peptide identification from shotgun proteomics datasets
Käll, L., Canterbury, J. D., Weston, J., Noble, W. S., & MacCoss, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1113 · Cited by 2,424
Towards a systems understanding of MHC class I and MHC class II antigen presentation
Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology · doi:10.1038/nri3084 · Cited by 2,044
Deep proteome and transcriptome mapping of a human cancer cell line
Nagaraj, N., Wisniewski, J. R., Geiger, T., Cox, J., Kircher, M., Kelso, J., Pääbo, S., & Mann, M. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.81 · Cited by 979
Cited by
O’Donnell, T. J., Rubinsteyn, A., & Laserson, U. (2020) · Cell Systems · doi:10.1016/j.cels.2020.06.010 · Cited by 440
Phosphoproteomics in the Age of Rapid and Deep Proteome Profiling
Riley, N. M., & Coon, J. J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04123 · Cited by 265
Solleder, M., Guillaume, P., Racle, J., Michaux, J., Pak, H.-S., Müller, M., Coukos, G., Bassani-Sternberg, M., & Gfeller, D. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.tir119.001641 · Cited by 68
Refsgaard, C. T., Barra, C., Peng, X., Ternette, N., & Nielsen, M. (2021) · ImmunoInformatics · doi:10.1016/j.immuno.2021.100005 · Cited by 12
Metadata
- Authors
- Mommen, G. P. M., Frese, C. K., Meiring, H. D., van Gaans-van den Brink, J., de Jong, A. P. J. M., van Els, C. A. C. M., & Heck, A. J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-10
- Volume
- 111
- Issue
- 12
- Pages
- 4507-4512
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996371910
- Cited by
- 183
- References
- 4
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Mommen, G. P. M., Frese, C. K., Meiring, H. D., van Gaans-van den Brink, J., de Jong, A. P. J. M., van Els, C. A. C. M., & Heck, A. J. R. (2014). Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1321458111
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