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Cited by 95

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

Senturk, Serif, Yao, Zhan, Camiolo, Matthew, Stiles, Brendon, Rathod, Trushar, Walsh, Alice M., Nemajerova, Alice, Lazzara, Matthew J., Altorki, Nasser K., Krainer, Adrian, Moll, Ute M., Lowe, Scott W., Cartegni, Luca, Sordella, Raffaella·2014·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1321640111
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Abstract

Significance: p53 is one of the most intensively studied tumor-suppressor genes. We identified a naturally occurring p53 isoform, generated by an alternative-splicing event, that, although lacking transcriptional activity and canonical tumor suppressor functions, is able to reprogram cells toward the acquisition of metastatic features via a cyclophilin D interaction in the mitochondria matrix. Interestingly, this isoform is expressed on tissue injury and in tumors characterized by increased metastatic spread. In some of these tumors, p53-like isoforms are generated by intron 6 mutations. This suggests a possible physiological origin of certain p53 mutations and indicates that mutations resulting in the generation of truncated p53Ψ-like proteins do more than create a 53-null state.

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Metadata

Authors
Senturk, S., Yao, Z., Camiolo, M., Stiles, B., Rathod, T., Walsh, A. M., Nemajerova, A., Lazzara, M. J., Altorki, N. K., Krainer, A., Moll, U. M., Lowe, S. W., Cartegni, L., & Sordella, R.
Affiliations
  • Cold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, NY 11724;
  • Department of Cardiothoracic Surgery, Weill Cornell Medical Center, New York, NY 10065;
  • Memorial Sloan-Kettering Cancer Center, New York, NY 10065;
  • Bioengineering Department, University of Pennsylvania, Philadelphia, PA 19104; and
  • Department of Pathology, Stony Brook University, Stony Brook, NY 11794
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2014-07-29
Volume
111
Issue
32
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1321640111
Cited by
95
References
7
Language
en

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CoChat. (2026). Citation check: p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. https://app.cochat.ai/papers/10.1073/pnas.1321640111
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Senturk, S., Yao, Z., Camiolo, M., Stiles, B., Rathod, T., Walsh, A. M., Nemajerova, A., Lazzara, M. J., Altorki, N. K., Krainer, A., Moll, U. M., Lowe, S. W., Cartegni, L., & Sordella, R. (2014). p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1321640111

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.