Cited by 197Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Activity-dependent dendritic spine neck changes are correlated with synaptic strength

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Araya, Roberto, Vogels, Tim P., Yuste, Rafael·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1321869111PMC PMC4104910

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Abstract

Significance: Dendritic spines are the main recipients of excitatory information in the brain, and though it is accepted that they must serve an essential function in neural circuits, their precise role remains ill-defined. Here, using minimal synaptic stimulation, we show that spine neck length correlates inversely with synaptic efficacy. In addition, we discovered a previously unidentified form of spine plasticity following a spike timing-dependent plasticity protocol, characterized by rapid shortening of spine neck length and concomitant increases in synaptic strength. These results provide new insights for our understanding of synaptic plasticity, and could provide an explanation for the presence of thousands of long-necked spines in the dendrites of pyramidal neurons, whose somatic synaptic contribution would otherwise be small or negligible.

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Authors: Araya, R., Vogels, T. P., & Yuste, R.
Affiliations: Université de Montréal (CA)
University of Oxford (GB)
Columbia University (US)
Corresponding author: Araya, Roberto
ORCID: Araya, Roberto
Vogels, Tim P.
Yuste, Rafael
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-06-30
Volume: 111
Issue: 28
Pages: E2895-904
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1321869111
PMC: PMC4104910
OpenAlex: W2164811687
Cited by: 197
References: 66
Citations by year: 2026: 10 · 2025: 7 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 12 · 2014: 6
FWCI: 8.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (100000, 090309/Z/09/Z, 090309)
European Commission (268436)
Multidisciplinary University Research Initiative (W911NF1210594)
National Institute on Drug Abuse (R21DA034195)
National Eye Institute (R01EY011787)
National Institute of Neurological Disorders and Stroke (R21NS081393)
Army Research Office (W911NF-12-1-0594, W911NF)
Army Research Laboratory (W911NF-12-1-0594, W911NF)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, synaptic plasticity, excitatory postsynaptic potentials, spike-timing-dependent plasticity, calcium imaging, glutamate uncaging, pyramidal neurons, neocortex, dendritic spine morphology, synaptic efficacy
MeSH terms: Animals, Dendrites, Female, Humans, Male, Neck, Synaptic Transmission, Spine, Synapses, Pyramidal Cells, Mice

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Activity-dependent dendritic spine neck changes are correlated with synaptic strength

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