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Activity-dependent dendritic spine neck changes are correlated with synaptic strength
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Significance: Dendritic spines are the main recipients of excitatory information in the brain, and though it is accepted that they must serve an essential function in neural circuits, their precise role remains ill-defined. Here, using minimal synaptic stimulation, we show that spine neck length correlates inversely with synaptic efficacy. In addition, we discovered a previously unidentified form of spine plasticity following a spike timing-dependent plasticity protocol, characterized by rapid shortening of spine neck length and concomitant increases in synaptic strength. These results provide new insights for our understanding of synaptic plasticity, and could provide an explanation for the presence of thousands of long-necked spines in the dendrites of pyramidal neurons, whose somatic synaptic contribution would otherwise be small or negligible.
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“It was shown that reduction of spine neck length after synaptic potentiation mediates enhanced electric coupling of spine and dendrite, thereby increasing the influence of the potentiated spine on the dendritic and somatic membrane potential (Araya et al., 2014; Tønnesen et al., 2014).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Araya et al., 2014
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Metadata
- Authors
- Araya, R., Vogels, T. P., & Yuste, R.
- Affiliations
- Université de Montréal (CA)
- University of Oxford (GB)
- Columbia University (US)
- Corresponding author
- Araya, Roberto
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-30
- Volume
- 111
- Issue
- 28
- Pages
- E2895-904
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4104910
- OpenAlex
- W2164811687
- Cited by
- 197
- References
- 66
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 12 · 2014: 6
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100000, 090309/Z/09/Z, 090309)
- European Commission (268436)
- Multidisciplinary University Research Initiative (W911NF1210594)
- National Institute on Drug Abuse (R21DA034195)
- National Eye Institute (R01EY011787)
- National Institute of Neurological Disorders and Stroke (R21NS081393)
- Army Research Office (W911NF-12-1-0594, W911NF)
- Army Research Laboratory (W911NF-12-1-0594, W911NF)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, synaptic plasticity, excitatory postsynaptic potentials, spike-timing-dependent plasticity, calcium imaging, glutamate uncaging, pyramidal neurons, neocortex, dendritic spine morphology, synaptic efficacy
- MeSH terms
- Animals, Dendrites, Female, Humans, Male, Neck, Synaptic Transmission, Spine, Synapses, Pyramidal Cells, Mice
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