The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Activity-dependent dendritic spine neck changes are correlated with synaptic strength
Open accessAbstract
Significance: Dendritic spines are the main recipients of excitatory information in the brain, and though it is accepted that they must serve an essential function in neural circuits, their precise role remains ill-defined. Here, using minimal synaptic stimulation, we show that spine neck length correlates inversely with synaptic efficacy. In addition, we discovered a previously unidentified form of spine plasticity following a spike timing-dependent plasticity protocol, characterized by rapid shortening of spine neck length and concomitant increases in synaptic strength. These results provide new insights for our understanding of synaptic plasticity, and could provide an explanation for the presence of thousands of long-necked spines in the dendrites of pyramidal neurons, whose somatic synaptic contribution would otherwise be small or negligible.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It was shown that reduction of spine neck length after synaptic potentiation mediates enhanced electric coupling of spine and dendrite, thereby increasing the influence of the potentiated spine on the dendritic and somatic membrane potential (Araya et al., 2014; Tønnesen et al., 2014).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Araya et al., 2014
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 4×
“S3) (31, 46)—is inversely proportional to the spine neck length, with long-necked spines having small or negligible somatic voltage contributions (31).”
BackgroundResultInfluentialNeurobiology of cerebellar evolution and development
Snider, R. S. (1971) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(71)90269-0 · Cited by 1,510
Electric current flow in excitable cells
(1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80560-1 · Cited by 1,289
Harris, K. M., & Kater, S. B. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,020
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
Self-citationColonnier, M. (1968) · Brain Research · doi:10.1016/0006-8993(68)90234-5 · Cited by 946
Foundations of Cellular Neurophysiology
Johnston, D., & Wu, S. M.-S. (1994) · Medical Entomology and Zoology · Cited by 910
Activation of CaMKII in single dendritic spines during long-term potentiation
Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685
Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 641
Locally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · cited 11×
“Indeed, a recent study using superresolutionstimulated emission depletion and an uncaging LTP protocol has shown that activated spines undergo changes in spine head, neck length, and neck diameter (56).”
BackgroundMethodResultInfluentialSynapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579
Gatenby, J. B., & Tahmisian, T. N. (1957) · Journal of the Royal Microscopical Society · doi:10.1111/j.1365-2818.1957.tb02020.x · Cited by 544
Modulation of AMPA receptor unitary conductance by synaptic activity
Benke, T. A., Lüthi, A., Isaac, J. T. R., & Collingridge, G. L. (1998) · Nature · doi:10.1038/31709 · Cited by 533
Electric Current Flow in Excitable Cells.
(1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-6-916_1 · Cited by 532
Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies
Arellano, J. I. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.010.2007 · Cited by 529
Structure, development, and plasticity of dendritic spines
Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 523
Direct measurement of coupling between dendritic spines and shafts
Svoboda, K., Tank, D. W., & Denk, W. (1996) · Science · doi:10.1126/science.272.5262.716 · Cited by 472
The distribution and targeting of neuronal voltage-gated ion channels
Lai, H. C., & Jan, L. Y. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1938 · Cited by 469
Electron Microscopy of Synaptic Contacts on Dendrite Spines of the Cerebral Cortex
Gray, E. G. (1959) · Nature · doi:10.1038/1831592a0 · Cited by 462
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation
Charrier, C., Joshi, K., Coutinho-Budd, J., Kim, J.-E., Lambert, N., de Marchena, J., Jin, W.-L., Vanderhaeghen, P., Ghosh, A., Sassa, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.034 · Cited by 454
Spine neck plasticity regulates compartmentalization of synapses
Tønnesen, J., Katona, G., Rózsa, B., & Nägerl, U. V. (2014) · Nature Neuroscience · doi:10.1038/nn.3682 · Cited by 444
Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 429
Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation
Bolshakov, V. Y., & Siegelbaum, S. A. (1995) · Science · doi:10.1126/science.7569903 · Cited by 375
Koch, C., & Zador, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00413.1993 · Cited by 372
Koester, H. J., & Sakmann, B. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9596 · Cited by 348
Neuronal activity regulates diffusion across the neck of dendritic spines
Bloodgood, B. L., & Sabatini, B. L. (2005) · Science · doi:10.1126/science.1114816 · Cited by 344
Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.
Chen, J. L., Villa, K. L., Cha, J. W., So, P. T. C., Kubota, Y., & Nedivi, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.030 · Cited by 341
Facilitation at single synapses probed with optical quantal analysis
Oertner, T. G., Sabatini, B. L., Nimchinsky, E. A., & Svoboda, K. (2002) · Nature Neuroscience · doi:10.1038/nn867 · Cited by 320
Dendritic spines and distributed circuits
Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298
Self-citationSynaptic amplification by dendritic spines enhances input cooperativity
Harnett, M. T., Makara, J. K., Spruston, N., Kath, W. L., & Magee, J. C. (2012) · Nature · doi:10.1038/nature11554 · Cited by 288
Yuste, R., Majewska, A. K., Cash, S. S., & Denk, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01976.1999 · Cited by 288
Self-citationTwo types of calcium response limited to single spines in cerebellar Purkinje cells.
Denk, W. T., Sugimori, M., & Llinas, R. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8279 · Cited by 284
NMDA Receptor-Mediated Subthreshold Ca2+Signals in Spines of Hippocampal Neurons
Kovalchuk, Y., Eilers, J., Lisman, J. E., & Konnerth, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01791.2000 · Cited by 270
The spine neck filters membrane potentials
Araya, R., Jiang, J., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608755103 · Cited by 258
Self-citationYuste, R. (2010) · doi:10.7551/mitpress/9780262013505.001.0001 · Cited by 241
Self-citationThe dendritic spine: a multifunctional integrative unit
Shepherd, G. M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2197 · Cited by 221
Computational study of an excitable dendritic spine
Segev, I., & Rall, W. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.2.499 · Cited by 217
Synaptic amplification by active membrane in dendritic spines
Miller, J. P., Rall, W., & Rinzel, J. (1985) · Brain Research · doi:10.1016/0006-8993(85)90333-6 · Cited by 208
Regulation of Spine Calcium Dynamics by Rapid Spine Motility
Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 208
Self-citationCortical area and species differences in dendritic spine morphology
Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207
Self-citationThe neocortical microcircuit as a tabula rasa
Kalisman, N., Silberberg, G., & Markram, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407088102 · Cited by 203
Non-synaptic dendritic spines in neocortex
Arellano, J. I., Espinosa, A., Fairén, A. G., Yuste, R., & DeFelipe, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.015 · Cited by 179
Self-citationA Critical Role for Myosin IIB in Dendritic Spine Morphology and Synaptic Function
Ryu, J., Liu, L., Wong, T. P., Wu, D., Burette, A., Weinberg, R. J., Wang, Y. T., & Sheng, M. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.017 · Cited by 179
CORTICAL NEURONS WITH PARTICULAR REFERENCE TO THE APICAL DENDRITESPreprint
Chang, H.-T. (1952) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1952.017.01.019 · Cited by 172
Enoki, R., Hu, Y.-L., Hamilton, D. C., & Fine, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.026 · Cited by 166
Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization
Grunditz, Å., Holbro, N., Tian, L., Zuo, Y., & Oertner, T. G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-08.2008 · Cited by 157
Davidoff, R. A. (1979) · Neurology · doi:10.1212/wnl.29.12.1639 · Cited by 152
Membrane Potential Changes in Dendritic Spines during Action Potentials and Synaptic Input
Palmer, L. M., & Stuart, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5847-08.2009 · Cited by 149
Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs152 · Cited by 136
y Cajal, S. R. (1904) · Institutional Repository of the University of Granada (University of Granada) · Cited by 125
Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines
Bloodgood, B. L., Giessel, A. J., & Sabatini, B. L. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000190 · Cited by 119
Two-photon Na + imaging in spines and fine dendrites of central neurons
Rose, C. R., Kovalchuk, Y., Eilers, J., & Konnerth, A. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900123 · Cited by 116
Cellular mechanisms subserving changes in neuronal activity
Rutledge, L. T. (1975) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(75)90067-x · Cited by 111
On the electrical function of dendritic spines
Tsay, D., & Yuste, R. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.008 · Cited by 103
Self-citationMalinow, R., Otmakhov, N., Blum, K. I., & Lisman, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8170 · Cited by 88
Sodium channels amplify spine potentials
Araya, R., Nikolenko, V., Eisenthal, K. B., & Yuste, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705282104 · Cited by 80
Self-citationBurkhalter, A., Gonchar, Y., Mellor, R. L., & Nerbonne, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2599-06.2006 · Cited by 79
Conti, R., & Lisman, J. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0630290100 · Cited by 77
Holthoff, K., Zecevic, D., & Konnerth, A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184960 · Cited by 76
Is the function of dendritic spines to concentrate calcium?
Holmes, W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90098-v · Cited by 67
Electrical properties of dendritic spines
Christof Koch, A., & Poggio, T. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90043-7 · Cited by 58
Cited by
Sorted by citations
Illuminating dendritic function with computational models
Poirazi, P., & Papoutsi, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0301-7 · Cited by 313
Structure and function of a neocortical synapse
Holler, S., Köstinger, G., Martin, K. A. C., Schuhknecht, G. F. P., & Stratford, K. J. (2021) · Nature · doi:10.1038/s41586-020-03134-2 · Cited by 249
Local translation in neuronal compartments: how local is local?
Rangaraju, V., Dieck, S. T., & Schuman, E. M. (2017) · EMBO Reports · doi:10.15252/embr.201744045 · Cited by 203
Biochemical Computation for Spine Structural Plasticity
Nishiyama, J., & Yasuda, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.043 · Cited by 199
Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
Ramaswamy, S., & Markram, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00233 · Cited by 204
Metadata
- Authors
- Araya, R., Vogels, T. P., & Yuste, R.
- Affiliations
- Université de Montréal (CA)
- University of Oxford (GB)
- Columbia University (US)
- Corresponding author
- Araya, Roberto
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-30
- Volume
- 111
- Issue
- 28
- Pages
- E2895-904
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4104910
- OpenAlex
- W2164811687
- Cited by
- 197
- References
- 66
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 12 · 2014: 6
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100000, 090309/Z/09/Z, 090309)
- European Commission (268436)
- Multidisciplinary University Research Initiative (W911NF1210594)
- National Institute on Drug Abuse (R21DA034195)
- National Eye Institute (R01EY011787)
- National Institute of Neurological Disorders and Stroke (R21NS081393)
- Army Research Office (W911NF-12-1-0594, W911NF)
- Army Research Laboratory (W911NF-12-1-0594, W911NF)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, synaptic plasticity, excitatory postsynaptic potentials, spike-timing-dependent plasticity, calcium imaging, glutamate uncaging, pyramidal neurons, neocortex, dendritic spine morphology, synaptic efficacy
- MeSH terms
- Animals, Dendrites, Female, Humans, Male, Neck, Synaptic Transmission, Spine, Synapses, Pyramidal Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
