The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Near-infrared–actuated devices for remotely controlled drug delivery
Open accessAbstract
Significance: Devices that release a drug in response to a remote trigger would enable on-demand control of the timing and dose of drug released. They would allow the patient or physician to adjust therapy precisely to a target effect, thus improving treatment and reducing toxicity. We have developed implantable reservoirs that release a drug when irradiated with near-infrared laser light. The release rate was correlated to laser intensity, with negligible leakage between doses. Devices containing aspart, a fast-acting analog of insulin, were implanted in diabetic rats and were able to achieve glycemic control upon irradiation. Such devices can be loaded with a wide range of drugs to treat a variety of clinical indications.
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Cites
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Erosion kinetics of hydrolytically degradable polymers.
Tamada, J. A., & Langer, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.552 · Cited by 356
Self-citationBiocompatibility and drug delivery systems
Kohane, D. S., & Langer, R. (2010) · Chem. Sci. · doi:10.1039/c0sc00203h · Cited by 307
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Cited by
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Self-citationTransformable liquid-metal nanomedicine
Lu, Y., Hu, Q., Lin, Y., Pacardo, D. B., Wang, C., Sun, W., Ligler, F. S., Dickey, M. D., & Gu, Z. (2015) · Nature Communications · doi:10.1038/ncomms10066 · Cited by 593
Photoresponsive nanoparticles for drug delivery
Rwei, A. Y., Wang, W., & Kohane, D. S. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.004 · Cited by 318
Self-citationCheng, L., Zhang, X., Tang, J., Lv, Q., & Liu, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120964 · Cited by 303
Zhang, Y., Mickle, A. D., Gutruf, P., McIlvried, L. A., Guo, H., Wu, Y., Golden, J. P., Xue, Y., Grajales-Reyes, J. G., Wang, X., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw5296 · Cited by 195
Metadata
- Authors
- Timko, B. P., Arruebo, M., Shankarappa, S. A., McAlvin, J. B., Okonkwo, O. S., Mizrahi, B., Stefanescu, C. F., Gomez, L., Zhu, J., Zhu, A., Santamaria, J., Langer, R., & Kohane, D. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 4
- Pages
- 1349-1354
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166349229
- Cited by
- 207
- References
- 3
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Timko, B. P., Arruebo, M., Shankarappa, S. A., McAlvin, J. B., Okonkwo, O. S., Mizrahi, B., Stefanescu, C. F., Gomez, L., Zhu, J., Zhu, A., Santamaria, J., Langer, R., & Kohane, D. S. (2014). Near-infrared–actuated devices for remotely controlled drug delivery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1322651111
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