The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Transformable liquid-metal nanomedicine
Open accessAbstract
To date, numerous inorganic nanocarriers have been explored for drug delivery systems (DDSs). However, the clinical application of inorganic formulations has often been hindered by their toxicity and failure to biodegrade. We describe here a transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell. This formulation can be simply produced through a sonication-mediated method with bioconjugation flexibility. The resulting nanoparticles loaded with doxorubicin (Dox) have an average diameter of 107 nm and demonstrate the capability to fuse and subsequently degrade under a mildly acidic condition, which facilitates release of Dox in acidic endosomes after cellular internalization. Equipped with hyaluronic acid, a tumour-targeting ligand, this formulation displays enhanced chemotherapeutic inhibition towards the xenograft tumour-bearing mice. This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions provides a new strategy for engineering theranostic agents with low toxicity.
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Cites
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Cited by
Zhou, J., Yu, G., & Huang, F. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00898d · Cited by 677
Attributes, Fabrication, and Applications of Gallium‐Based Liquid Metal Particles
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Self-citationStretchable Capacitive Sensors of Torsion, Strain, and Touch Using Double Helix Liquid Metal Fibers
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Self-citationYe, Y., Wang, J., Hu, Q., Hochu, G. M., Xin, H., Wang, C., & Gu, Z. (2016) · ACS Nano · doi:10.1021/acsnano.6b04989 · Cited by 339
Self-citationAntibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation
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Metadata
- Authors
- Lu, Y., Hu, Q., Lin, Y., Pacardo, D. B., Wang, C., Sun, W., Ligler, F. S., Dickey, M. D., & Gu, Z.
- Venue
- Nature Communications
- Published
- 2015-12-02
- Volume
- 6
- Issue
- 1
- Pages
- 10066-10066
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2191460975
- Cited by
- 593
- References
- 36
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lu, Y., Hu, Q., Lin, Y., Pacardo, D. B., Wang, C., Sun, W., Ligler, F. S., Dickey, M. D., & Gu, Z. (2015). Transformable liquid-metal nanomedicine. Nature Communications. https://doi.org/10.1038/ncomms10066
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