The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction
Open accessAbstract
Significance: Early prenatal stress (EPS), a key risk factor for neurodevelopmental disorders, produces a marked reduction in O -GlcNAc transferase (OGT) in male placental tissue. In our current work, we determined that a targeted reduction of placental OGT recapitulates key features of EPS, including hypothalamic–pituitary–adrenal stress axis dysregulation, reduced postpubertal growth, and hypothalamic mitochondrial dysfunction. These results confirm that OGT serves as a key placental biomarker and functions as an important mediator of the maternal changes occurring in response to stress.
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Early Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961
Self-citationlinking metabolism to epigenetics through O-GlcNAcylation
Hanover, J. A., Krause, M. W., & Love, D. C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3334 · Cited by 414
Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression
Gambetta, M. C., Oktaba, K., & Müller, J. (2009) · Science · doi:10.1126/science.1169727 · Cited by 315
Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306
The Human Placenta Expresses CYP17 and Generates Androgens De Novo
Escobar, J. C., Patel, S. S., Beshay, V. E., Suzuki, T., & Carr, B. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2504 · Cited by 80
Cited by
Epigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505
Self-citationDevelopmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Jašarević, E., Howerton, C. L., Howard, C. D., & Bale, T. L. (2015) · Endocrinology · doi:10.1210/en.2015-1177 · Cited by 329
Self-citationJašarević, E., Howard, C. D., Misic, A. M., Beiting, D. P., & Bale, T. L. (2017) · Scientific Reports · doi:10.1038/srep44182 · Cited by 262
Self-citationRosenfeld, C. S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24603 · Cited by 280
Metadata
- Authors
- Howerton, C. L., & Bale, T. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-16
- Volume
- 111
- Issue
- 26
- Pages
- 9639-9644
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117892530
- Cited by
- 159
- References
- 5
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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