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Engineered nanomedicine for myeloma and bone microenvironment targeting
Open accessAbstract
Significance: Limited treatment options exist for cancer within the bone, as demonstrated by the inevitable, pernicious course of metastatic breast, prostate, and blood cancers. The difficulty of eliminating bone-residing cancer necessitates novel, alternative treatments to manipulate the tumor cells and their microenvironment, with minimal off-target effects. To this end, we engineered bone-homing, stealth nanoparticles to deliver anticancer, bone-stimulatory drugs, and demonstrated their utility with bortezomib (a model drug) and multiple myeloma (a model cancer). To test our hypothesis that increasing bone volume and strength inhibits tumor growth, mice were treated with these nanoparticles before being injected with cancer cells. Results demonstrated significantly slower myeloma growth and prolonged survival. Our research demonstrates the potential of bone-homing nanomedicine as an efficacious cancer treatment mechanism.
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Dempster, D. W., Compston, J. E., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., Recker, R. R., & Parfitt, A. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1805 · Cited by 2,543
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Metadata
- Authors
- Swami, A., Reagan, M. R., Basto, P., Mishima, Y., Kamaly, N., Glavey, S., Zhang, S., Moschetta, M., Seevaratnam, D., Zhang, Y., Liu, J., Memarzadeh, M., Wu, J., Manier, S., Shi, J., Bertrand, N., Lu, Z. N., Nagano, K., Baron, R., Sacco, A., Roccaro, A. M., Farokhzad, O. C., & Ghobrial, I. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-30
- Volume
- 111
- Issue
- 28
- Pages
- 10287-10292
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089220360
- Cited by
- 283
- References
- 1
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Swami, A., Reagan, M. R., Basto, P., Mishima, Y., Kamaly, N., Glavey, S., Zhang, S., Moschetta, M., Seevaratnam, D., Zhang, Y., Liu, J., Memarzadeh, M., Wu, J., Manier, S., Shi, J., Bertrand, N., Lu, Z. N., Nagano, K., Baron, R., . . . Ghobrial, I. M. (2014). Engineered nanomedicine for myeloma and bone microenvironment targeting. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1401337111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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