The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7
Abstract
Significance: MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression. The aberrant expression of miRNAs is commonly associated with cancer. miRNAs can be packaged in exosomes/microvesicles secreted by the cells and involved in cell-to-cell signaling and communication; tumor-secreted miRNAs promote tumor spread and growth in the surrounding microenvironment. Apoptosis is reported to take place in wasting muscle in cancer cachexia, a debilitating syndrome associated with multiple types of cancer, although the mechanism remains elusive. This study shows that tumor-secreted microvesicles contain an elevated expression of miR-21 and induce myoblast apoptosis in cancer cachexia via a Toll-like receptor 7-c-Jun N-terminal kinase-dependent pathway.
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“the principle of an intercellular crosstalk based on extracellular miRNA is well established in human cancer models [19, 82]”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [82]
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Metadata
- Authors
- He, W. A., Calore, F., Londhe, P., Canella, A., Guttridge, D. C., & Croce, C. M.
- Affiliations
- Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, and the Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-03-10
- Volume
- 111
- Issue
- 12
- Pages
- 4525-4529
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 235
- References
- 7
- Language
- en
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