Cited by 64Muscle Physiology and DisordersCongenital heart defects researchWound Healing and Treatments

Muscle cell communication in development and repair

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Demonbreun, Alexis R, McNally, Elizabeth M·2017·Current Opinion in Pharmacology

Abstract

Under basal conditions, postnatal skeletal muscle displays little cell turnover. With injury, muscle initiates a rapid repair response to reseal damaged membrane, reactivating many developmental pathways to facilitate muscle regeneration and prevent tissue loss. Muscle precursor cells become activated accompanied by differentiation and fusion during both muscle growth and regeneration; inter-cellular communication is required for successful completion of these processes. Cellular communication is mediated by lipids, fusogenic membrane proteins, and exosomes. Muscle-derived exosomes carry proteins and micro RNAs as cargo. Secreted factors such as IGF-1, TGFβ, and myostatin are also released by muscle cells providing local signaling cues to modulate muscle fusion and regeneration. Proteins that regulate myoblast fusion also participate in membrane repair and regeneration. Here we will review methods of muscle cell communication focusing on proteins that mediate membrane fusion, exosomes, and autocrine factors.

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Crossref · 10.1016/j.coph.2017.03.008

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Authors
Demonbreun, A. R., & McNally, E. M.
Affiliations
Northwestern University (US)
Corresponding author
McNally, Elizabeth M
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2017-06
Volume
34
Pages
7-14
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2606079720
Cited by
64
References
82
Citations by year
2026: 7 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 3
FWCI
0.64
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (NS047726, NS072027, HL061322)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
skeletal muscle regeneration, muscle injury repair, myoblast fusion, membrane repair, exosomes, microRNA, insulin-like growth factor I, TGF-beta, myostatin, autocrine signaling, myogenesis, muscle precursor cells
MeSH terms
Animals, Cell Communication, Cell Membrane, Humans, Phospholipids, Regeneration, Muscle, Skeletal, Muscle Cells, MicroRNAs, Exosomes

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