MicroRNAs and miRceptors: a new mechanism of action for intercellular communication
Open accessAbstract
MicroRNAs (miRs) are small non-coding RNAs (ncRNAs) that control the expression of target genes by modulating (usually inhibiting) their translation into proteins. This 'traditional' mechanism of action of miRs has been recently challenged by new discoveries pointing towards a role of miRs as 'hormones', capable of binding to proteic receptors (miRceptors) and triggering their downstream signalling pathways. These findings harbour particular significance within the tumour microenvironment (TME), defined as the variety of non-cancerous cells surrounding cancer cells, but are relevant also for other diseases. In recent years it has become clearer that the TME does not passively assist the growth of cancer cells but contributes to its biology. Some of the mediators of the intercellular communication between cancer cells and TME are miRs shuttled within exosomes, a subtype of cellular released extracellular vesicles. This article will highlight the most recent findings on the biological implications of miR-miRceptor interactions for the biology of the TME and other diseases, and will provide some perspectives on the future development of this fascinating research.This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'.
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Some miRNAs can interact with cell surface receptors, such as Toll-like receptors.
“Some miRNAs can even interact with cell surface receptors, such as Toll-like receptors.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [137]
Apart from Toll-like receptors, miRceptors remain to be identified.
“Although miRceptors have been proposed (137), apart from the Toll-like receptors, they remain to be identified.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [137]
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- Authors
- Fabbri, M.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Fabbri, Muller
- ORCID
- Fabbri, Muller
- Venue
- Philosophical Transactions of the Royal Society B Biological Sciences
- Publisher
- The Royal Society
- Published
- 2017-11-20
- Volume
- 373
- Issue
- 1737
- Pages
- 20160486
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC5717440
- OpenAlex
- W2770855058
- Cited by
- 65
- References
- 43
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hugh and Audy Lou Colvin Foundation
- Stop Cancer
- NIH- National Cancer Institute (1R01 CA215733-01A1, P30CA014089)
- Hyundai Hope On Wheels
- William Lawrence & Blanche Hughes Foundation
- Nautica Malibu Triathlon
- Jean Perkins Foundation
- St. Baldrick's Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, intercellular communication, tumor microenvironment, extracellular vesicles, exosomes, non-coding RNA, tumor biology
- MeSH terms
- Extracellular Vesicles, Cell Communication, Humans, MicroRNAs, Tumor Microenvironment
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