The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
Open accessAbstract
Significance: Interleukin-33 (IL-33) is an IL-1 family cytokine with important roles in type-2 immunity and human asthma. IL-33 is a key activator of the recently described group-2 innate lymphoid cells (ILC2s), which are involved in the initiation of allergic inflammation. Here, we investigated the mechanisms regulating IL-33 activity. We discovered that mast cells, critical effector cells in allergic disorders, secrete proteases, which cleave IL-33 and generate mature forms with increased biological activity. We demonstrate that these mature forms of IL-33 are 30-fold more potent than full-length IL-33 for activation of ILC2s. Our study suggests that inhibition of IL-33 cleavage by mast cell and other inflammatory proteases could be useful to limit IL-33–mediated responses in allergic asthma and other inflammatory diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,710
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Di Santo, J. P., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2013) · Nature Reviews Immunology · doi:10.1038/nri3365 · Cited by 2,389
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J.-I., Ohtani, M., Fujii, H., & Koyasu, S. (2010) · Nature · doi:10.1038/nature08636 · Cited by 1,992
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K. A., Bucks, C., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 1,938
A large-scale, consortium-based genomewide association study of asthma
Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., Heath, S., von Mutius, E., Farrall, M., Lathrop, M., & Cookson, W. O. C. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 1,818
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G. K., Doering, T. A., Angelosanto, J. M., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., et al. (2011) · Nature Immunology · doi:10.1038/ni.2131 · Cited by 1,321
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
Mast cells in the development of adaptive immune responses
Galli, S. J., Nakae, S., & Tsai, M. (2005) · Nature Immunology · doi:10.1038/ni1158 · Cited by 1,279
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179
Self-citation
Cited by
Overview of the IL ‐1 family in innate inflammation and acquired immunity
Dinarello, C. A. (2018) · Immunological Reviews · doi:10.1111/imr.12621 · Cited by 1,866
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Early local immune defences in the respiratory tract
Iwasaki, A., Foxman, E. F., & Molony, R. D. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.117 · Cited by 328
Androgen signaling negatively controls group 2 innate lymphoid cells
Laffont, S., Blanquart, E., Savignac, M., Cénac, C., Laverny, G., Metzger, D., Girard, J.-P., Belz, G. T., Pelletier, L., Seillet, C., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161807 · Cited by 282
Self-citationHpARI protein secreted by a helminth parasite suppresses interleukin-33
Osbourn, M., Soares, D. C., Vacca, F., Cohen, E. S., Scott, I. C., Gregory, W. F., Smyth, D. J., Toivakka, M., Kemter, A. M., le Bihan, T., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.015 · Cited by 178
Metadata
- Authors
- Lefrançais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C., & Girard, J.-P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-10-13
- Volume
- 111
- Issue
- 43
- Pages
- 15502-15507
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069609111
- Cited by
- 384
- References
- 48
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. https://app.cochat.ai/papers/10.1073/pnas.1410700111
- The paper
- Lefrançais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C., & Girard, J.-P. (2014). Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1410700111
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
