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Investigating the optimal size of anticancer nanomedicine
Open accessAbstract
Significance: Understanding the interdependency of physiochemical properties of nanomedicine (NM) in correlation to its biological response and function is crucial for additional development of anticancer NM. Here, we prepared monodisperse drug–silica nanoconjugates in three distinct sizes (20, 50, and 200 nm) with other physiochemical properties controlled to be identical to investigate size-dependent biodistribution, tumor tissue penetration and clearance, and anticancer efficacy in various tumor models. We also developed a mathematical model of the spatiotemporal distribution of NM within a tumor to gain insight into the size-dependent interaction with tumor. Our studies show clear evidence that there is an optimal size of anticancer NM and that NM with the optimal size has the highest tumor retention integrated over time.
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Self-citationStrategies to improve the EPR effect: A mechanistic perspective and clinical translation
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Metadata
- Authors
- Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M., & Cheng, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-10-14
- Volume
- 111
- Issue
- 43
- Pages
- 15344-15349
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2126036312
- Cited by
- 654
- References
- 6
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M., & Cheng, J. (2014). Investigating the optimal size of anticancer nanomedicine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1411499111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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