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Cited by 350Circadian rhythm and melatoninSleep and Work-Related FatigueRegulation of Appetite and Obesity

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Impact of circadian misalignment on energy metabolism during simulated nightshift work

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McHill, Andrew W., Melanson, Edward L., Higgins, Janine, Connick, Elizabeth, Moehlman, Thomas M., Stothard, Ellen R., Wright, Kenneth P.·2014·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1412021111PMC PMC4260578
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Abstract

Significance: Demands of modern society force many work operations into the night, when the intrinsic circadian timing system promotes sleep. Overnight shiftwork is associated with increased risk for adverse metabolic health and sleep disruption. Uncovering potential physiological mechanisms that contribute to metabolic dysregulation when work and eating occur at inappropriate circadian times is vital to the development of effective treatment strategies. In this study, healthy volunteers underwent a commonly used simulated shiftwork protocol to quantify changes in metabolic, sleep, and circadian physiology when working and eating during the night as compared with a traditional day work schedule. We demonstrate that nightshift work reduces total daily energy expenditure, representing a contributing mechanism for unwanted weight gain and obesity.

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Crossref · 10.1073/pnas.1412021111

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  1. G Keppel Design and Analysis: A Researcher’s Handbook (Prentice Hall, Englewood Cliffs, NJ, 1991).

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Metadata

Authors
McHill, A. W., Melanson, E. L., Higgins, J., Connick, E., Moehlman, T. M., Stothard, E. R., & Wright, K. P.
Affiliations
  • University of Colorado Boulder (US)
  • Endocrinology, Metabolism, and Diabetes,
  • University of Colorado Anschutz (US)
  • Infectious Diseases and
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2014-11-17
Volume
111
Issue
48
Pages
17302-17307
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1412021111
PMC
PMC4260578
OpenAlex
W2069822948
Cited by
349
References
46
Citations by year
2026: 24 · 2025: 26 · 2024: 27 · 2023: 39 · 2022: 38 · 2021: 25 · 2020: 34 · 2019: 32 · 2018: 24 · 2017: 34 · 2016: 23 · 2015: 23
FWCI
13.00
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (UL1TR001082)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK092624, P30DK048520)
  • National Center for Research Resources (UL1RR025780)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
circadian misalignment, night shift work, shift work, energy expenditure, thermic effect of feeding, fat utilization, carbohydrate utilization, protein utilization, leptin, peptide YY, sleep disruption, obesity risk
MeSH terms
Adult, Analysis of Variance, Circadian Rhythm, Eating, Electromyography, Energy Metabolism, Female, Humans, Male, Melatonin, Obesity, Risk Factors, Sleep, Sleep Deprivation, Sleep Stages, Time Factors, Wakefulness, Work Schedule Tolerance, Weight Gain, Peptide YY, Leptin, Ghrelin

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