The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Impact of circadian misalignment on energy metabolism during simulated nightshift work
Open accessAbstract
Significance: Demands of modern society force many work operations into the night, when the intrinsic circadian timing system promotes sleep. Overnight shiftwork is associated with increased risk for adverse metabolic health and sleep disruption. Uncovering potential physiological mechanisms that contribute to metabolic dysregulation when work and eating occur at inappropriate circadian times is vital to the development of effective treatment strategies. In this study, healthy volunteers underwent a commonly used simulated shiftwork protocol to quantify changes in metabolic, sleep, and circadian physiology when working and eating during the night as compared with a traditional day work schedule. We demonstrate that nightshift work reduces total daily energy expenditure, representing a contributing mechanism for unwanted weight gain and obesity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a study of simulated night shiftwork in normal weight women, reductions in both total daily energy expenditure and the thermic effect of dinner were highlighted as contributing mechanisms for weight gain, obesity and impaired health as a result of shiftwork [27].”
From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [27]
Citations
Cites
‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857
Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
Book Review: Design and Analysis: A Researcher's Handbook
Aaker, D. A., & Keppel, G. (1976) · Journal of Marketing Research · doi:10.2307/3150757 · Cited by 2,033
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Sleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Dijk, D., & Czeisler, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03526.1995 · Cited by 1,356
Circadian timing of food intake contributes to weight gain
Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932
Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain
Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216951110 · Cited by 810
Self-citationLight at night increases body mass by shifting the time of food intake
Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796
Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle
Wright, K. P., McHill, A. W., Birks, B. R., Griffin, B. R., Rusterholz, T., & Chinoy, E. D. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.039 · Cited by 783
Self-citationSleep loss and fatigue in shift work and shift work disorder
Åkerstedt, T., & Wright, K. P. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.03.001 · Cited by 639
Self-citationLeproult, R., Holmbäck, U., & Van Cauter, E. (2014) · Diabetes · doi:10.2337/db13-1546 · Cited by 607
Role of sleep timing in caloric intake and BMI
Baron, K. G., Reid, K. J., Kern, A. S., & Zee, P. C. (2011) · Obesity · doi:10.1038/oby.2011.100 · Cited by 549
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547
Assessment of Energy Expenditure and Fuel Utilization in Man
Jéquier, E., Acheson, K. J., & Schütz, Y. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.001155 · Cited by 532
Proposed diagnostic criteria for night eating syndrome
Allison, K. C., Lundgren, J. D., O’Reardon, J. P., Geliebter, A., Gluck, M. E., Vinai, P., Mitchell, J. E., Schenck, C. H., Howell, M. J., Crow, S. J., et al. (2009) · International Journal of Eating Disorders · doi:10.1002/eat.20693 · Cited by 403
A Time to Work: Recent Trends in Shift Work and Flexible Schedules
McMenamin, T. M. (2007) · Monthly labor review · Cited by 389
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351
Di Lorenzo, L., De Pergola, G., Zocchetti, C., L'Abbate, N., Basso, A., Pannacciulli, N., Cignarelli, M., Giorgino, R., & Soleo, L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802419 · Cited by 346
Colles, S. L., Dixon, J. B., & O'Brien, P. E. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803664 · Cited by 324
Jung, C. M., Melanson, E. L., Frydendall, E. J., Perreault, L., Eckel, R. H., & Wright, K. P. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197517 · Cited by 318
Self-citationScheer, F. A. J. L., Morris, C. J., & Shea, S. A. (2013) · Obesity · doi:10.1002/oby.20351 · Cited by 296
Dodt, C., Breckling, U., Derad, I., Fehm, H. L., & Jan Born, A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.71 · Cited by 252
Perspective: Casting light on sleep deficiency
Czeisler, C. A. (2013) · Nature · doi:10.1038/497s13a · Cited by 243
Effect of cortisol on energy expenditure and amino acid metabolism in humans
Brillon, D. J., Zheng, B., Campbell, R. G., & Matthews, D. E. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.3.e501 · Cited by 206
Circadian variation of diet-induced thermogenesis
Romon, M., Edme, J., Boulenguez, C., Lescroart, J., & Frimat, P. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.4.476 · Cited by 197
The Effects of Shift Work on Sleeping Quality, Hypertension and Diabetes in Retired Workers
Guo, Y., Liu, Y., Huang, X., Rong, Y., He, M., Wang, Y., Yuan, J., Wu, T., & Chen, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071107 · Cited by 153
Metabolic syndrome and shift work: a systematic review
Canuto, R., Garcez, A. S., & Olinto, M. T. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.10.004 · Cited by 130
Nocturnal eating and serum cholesterol of three-shift workers.
Lennernäs, M. A. ‐., Åkerstedt, T., & Hambræus, L. (1994) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1381 · Cited by 96
Relationship between sleep stages and metabolic rate in humans
Fontvieille, A. M., Rising, R., Spraul, M., Larson, D. E., & Ravussin, É. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.5.e732 · Cited by 90
Metabolic Responses to Nocturnal Eating in Men Are Affected by Sources of Dietary Energy
Holmbäck, U. C., Forslund, A. H., Forslund, J., Hambræus, L., Lennernäs, M. A. ‐., Löwden, A., Stridsberg, M., & Åkerstedt, T. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.1892 · Cited by 76
Influence of weeks of circadian misalignment on leptin levels
Wright (2009) · Nature and Science of Sleep · doi:10.2147/nss.s7624 · Cited by 74 · cited 3×
“Our findings also provide further evidence that leptin and ghrelin are primarily modulated by wakefulness–sleep, feeding–fasting cycles compared with circadian phase (5, 18).”
BackgroundA new approach for flow-through respirometry measurements in humans
Melanson, E. L., Ingebrigtsen, J. P., Bergouignan, A., Ohkawara, K., Kohrt, W. M., & Lighton, J. R. B. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00055.2010 · Cited by 69
Self-citationChin-Chance, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2685 · Cited by 69
Hurni, M., Burnand, B., Pittet, P., & Jequier, E. (1982) · British Journal of Nutrition · doi:10.1079/bjn19820006 · Cited by 68
McHill, A. W., Smith, B. J., & Wright, K. P. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414523078 · Cited by 52
Self-citationRole of alpha- and beta-adrenoceptors in sympathetically mediated thermogenesis
Blaak, E. E., van Baak, M. A., Kempen, K. P., & Saris, W. H. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.1.e11 · Cited by 48
Chemiluminescent measurement of total urinary nitrogen for accurate calculation of nitrogen balance.
Skogerboe, K. J., Labbé, R. F., Rettmer, R. L., Sundquist, J., & Gargett, A. M. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.5.752 · Cited by 44
Markwald, R. R., & Wright, K. P. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3492-4_8 · Cited by 33
Self-citationRehman, J.-U., Brismar, K., Holmbäck, U. C., Åkerstedt, T., & Axelsson, J. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0297 · Cited by 22
Gonnissen, H. K. J., Drummen, M., Rosique-Esteban, N., Schoffelen, P. F. M., & Westerterp‐Plantenga, M. S. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.067884 · Cited by 15
Research works printed but not linked: 1
- G Keppel Design and Analysis: A Researcher’s Handbook (Prentice Hall, Englewood Cliffs, NJ, 1991).
Cited by
Sorted by citations
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 781
Circadian regulation of glucose, lipid, and energy metabolism in humans
Poggiogalle, E., Jamshed, H., & Peterson, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.017 · Cited by 743
The role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 733
Self-citationCircadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 635
Metadata
- Authors
- McHill, A. W., Melanson, E. L., Higgins, J., Connick, E., Moehlman, T. M., Stothard, E. R., & Wright, K. P.
- Affiliations
- University of Colorado Boulder (US)
- Endocrinology, Metabolism, and Diabetes,
- University of Colorado Anschutz (US)
- Infectious Diseases and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-11-17
- Volume
- 111
- Issue
- 48
- Pages
- 17302-17307
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4260578
- OpenAlex
- W2069822948
- Cited by
- 349
- References
- 46
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 27 · 2023: 39 · 2022: 38 · 2021: 25 · 2020: 34 · 2019: 32 · 2018: 24 · 2017: 34 · 2016: 23 · 2015: 23
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001082)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK092624, P30DK048520)
- National Center for Research Resources (UL1RR025780)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- circadian misalignment, night shift work, shift work, energy expenditure, thermic effect of feeding, fat utilization, carbohydrate utilization, protein utilization, leptin, peptide YY, sleep disruption, obesity risk
- MeSH terms
- Adult, Analysis of Variance, Circadian Rhythm, Eating, Electromyography, Energy Metabolism, Female, Humans, Male, Melatonin, Obesity, Risk Factors, Sleep, Sleep Deprivation, Sleep Stages, Time Factors, Wakefulness, Work Schedule Tolerance, Weight Gain, Peptide YY, Leptin, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
