The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential
Open accessAbstract
Significance: In this study, we found that human endogenous retoriviruses type-H (HERV-Hs) are transiently hyperactivated during reprogramming toward induced pluripotent stem cells (iPSCs) and play important roles in this process. However, when reprogramming is complete and cells acquire full pluripotency, HERV-H activity should decrease to levels comparable with those in embryonic stem cells because failure to resilence this activity leads to the differentiation-defective phenotype in neural lineage. We also found that during reprogramming, reprogramming factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), and Krüppel-like factor 4 (KLF4) (OSK) bind to and activate long-terminal repeats of HERV-Hs. KLF4 possibly precludes Tripartite motif containing 28 and recruits not only OCT3/4 and SOX2, but also E1A binding protein p300 (p300) histone acethyltransferase on HERV-H loci. Therefore, OKSM-induced HERV-H activation constitutes an unanticipated and critical mechanism for iPSC formation.
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Self-citationEmbryonic Stem Cell Lines Derived from Human Blastocysts
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Self-citationpiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
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Self-citationLinking the p53 tumour suppressor pathway to somatic cell reprogramming
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Regulatory activities of transposable elements: from conflicts to benefits
Chuong, E. B., Elde, N. C., & Feschotte, C. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,489
Roles of transposable elements in the regulation of mammalian transcription
Fueyo, R., Judd, J., Feschotte, C., & Wysocka, J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00457-y · Cited by 451
The landscape of viral associations in human cancers
Zapatka, M., Borozan, I., Brewer, D. S., Iskar, M., Grundhoff, A., Alawi, M., Desai, N., Sültmann, H., Moch, H., Pathogens, P., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0558-9 · Cited by 382
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 295
Nishizawa, M., Chonabayashi, K., Nomura, M., Tanaka, A., Nakamura, M., Inagaki, A., Nishikawa, M., Takei, I., Oishi, A., Tanabe, K., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.019 · Cited by 234
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Metadata
- Authors
- Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I., Sawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y., Nakamura, M., Watanabe, A., Yamanaka, S., & Takahashi, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-05
- Volume
- 111
- Issue
- 34
- Pages
- 12426-12431
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082918475
- Cited by
- 263
- References
- 39
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I., Sawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y., Nakamura, M., Watanabe, A., Yamanaka, S., & Takahashi, K. (2014). Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1413299111
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