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Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions
Open accessAbstract
Significance: Clinical studies report that a single, low dose of ketamine produces a rapid antidepressant response in treatment-resistant depressed patients. Although rodent studies have begun to elucidate the molecular mechanisms underlying the behavioral actions of ketamine, the brain regions and cellular mechanisms have not been defined. Using a combination of pharmacological silencing and optogenetic stimulation approaches, the results of the current study demonstrate that ketamine infusion or optogenetic stimulation of the infalimbic prefrontal cortex produces antidepressant behavioral and synaptic responses similar to the actions of systemic ketamine. These findings further elucidate the mechanisms underlying the therapeutic actions of ketamine and will enhance the development of safer rapid-acting and efficacious agents.
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“In contrast, prolonged ILc pyramidal stimulation for 60 min mirrored the putative antidepressant effects of ketamine on sucrose preference, while neuronal silencing of ILc (and not PLc), using the GABA-A agonist, muscimol, blocked the actions of ketamine, 24 h later [63].”
From Prefrontal cortex and depression (2022) · cites this paper as [63]
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“Our findings build upon prior studies showing that non-selective activation of the mPFC can reverse behavioral deficits in depression models [36–39]”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [37]
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“Duman et al. found that optogenetic stimulation of the infralimbic cortex produces rapid and sustained antidepressant-like effects comparable to ketamine in the forced swim, novelty-suppressed feeding, and sucrose preference tests (181).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [181]
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“microinfusion of ketamine into the infralimbic cortex produces comparable antidepressant-effects as systemic administration of ketamine and inactivation of the infralimbic cortex with muscimol was sufficient to block the antidepressant-like effects of systemic ketamine (181).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [181]
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“In contrast, prolonged ILc pyramidal stimulation for 60 min mirrored the putative antidepressant effects of ketamine on sucrose preference, while neuronal silencing of ILc (and not PLc), using the GABA-A agonist, muscimol, blocked the actions of ketamine, 24 h later [63].”
From Prefrontal cortex and depression (2022) · cites this paper as [63]
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“neuronal silencing of IL (and not PL) blocks the actions of ketamine, 24 h later [63]”
From Prefrontal cortex and depression (2022) · cites this paper as [63]
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“prolonged ILc pyramidal stimulation for 60 min, mirroring the actions of ketamine to promote active coping on FST [63].”
From Prefrontal cortex and depression (2022) · cites this paper as [63]
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Self-citationAntidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Self-citationHomeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 1×
“In addition, depressed patients are reported to have reduced activity in the PFC (10) that is normalized with treatment (11).”
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Sala, N., Paoli, C., Bonifacino, T., Mingardi, J., Schiavon, E., Via, L. L., Milanese, M., Tornese, P., Datusalia, A. K., Rosa, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.759626 · Cited by 38
Enhanced activity of pyramidal neurons in the infralimbic cortex drives anxiety behavior
Berg, L., Eckardt, J., & Masseck, O. A. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210949 · Cited by 38
Yu, Z., Han, Y., Hu, D., Chen, N., Zhang, Z., Chen, W., Xue, Y.-X., Meng, S., Lü, L., Zhang, W., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01495-w · Cited by 39
Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice
Yin, Y., Hu, J., Wei, Y., Li, Z., Luo, Z.-C., Wang, R., Yang, K.-X., Li, S.-J., Li, X., Yang, J., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00553-z · Cited by 39
Villaruel, F. R., Lacroix, F., Sanio, C., Sparks, D. W., Chapman, C. A., & Chaudhri, N. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx275 · Cited by 36
Ma, L., Skoblenick, K. J., Seamans, J. K., & Everling, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1839-15.2015 · Cited by 35
The Role of Glutamine Homeostasis in Emotional and Cognitive Functions
Baek, J. H., Park, H., Kang, H., Kim, R., Kang, J. S., & Kim, H. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021302 · Cited by 35
Repurposing of Drugs–The Ketamine Story
Das, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01193 · Cited by 41
Scotton, E., Antqueviezc, B., Vasconcelos, M., Dalpiaz, G., Géa, L. P., Goularte, J. F., Colombo, R., & Rosa, A. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114963 · Cited by 37
Björkholm, C., Marcus, M. M., Konradsson‐Geuken, Å., Jardemark, K. E., & Svensson, T. H. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.01.014 · Cited by 32
Amat-Foraster, M., Jensen, A. A., Plath, N., Herrik, K. F., Celada, P., & Artigas, F. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.022 · Cited by 34
Pothula, S., Liu, R.-J., Wu, M., Sliby, A., Picciotto, M. R., Banerjee, P., & Duman, R. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00882-7 · Cited by 32
Self-citationPace, S. A., Christensen, C. W., Schackmuth, M. K., Wallace, T., McKlveen, J. M., Beischel, W. J., Morano, R. L., Scheimann, J. R., Wilson, S. P., Herman, J. P., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100274 · Cited by 32
mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse
Garro-Martínez, E., Fullana, M. N., Florensa-Zanuy, E., Senserrich, J., Paz, V., Ruiz‐Bronchal, E., Adell, A., Castro, E., Díaz, Á., Pazos, Á., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168671 · Cited by 31
West, E. A., Niedringhaus, M. S., Ortega, H. K., Haake, R. M., Frӧhlich, F., & Carelli, R. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.027 · Cited by 34
Alexander, L., Hawkins, P. C. T., Evans, J. W., Mehta, M. A., & Zarate, C. A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02674-1 · Cited by 29
Chaki, S., & Fukumoto, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061270 · Cited by 29
Okada, M., Fukuyama, K., Nakano, T., & Ueda, Y. (2019) · Biomolecules · doi:10.3390/biom9110746 · Cited by 29
Riga, M. S., Teruel‐Martí, V., Sánchez, C., Celada, P., & Artigas, F. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.024 · Cited by 29
mGlu receptors as potential targets for novel antidepressants
Chaki, S., & Fukumoto, K. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.02.001 · Cited by 30
Potential of Glutamate-Based Drug Discovery for Next Generation Antidepressants
Chaki, S., & Fukumoto, K. (2015) · Pharmaceuticals · doi:10.3390/ph8030590 · Cited by 29
Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice
Botterill, J. J., Khlaifia, A., Appings, R., Wilkin, J., Violi, F., Premachandran, H., Cruz-Sanchez, A., Canella, A. E., Patel, A., Zaidi, S. D., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01795-5 · Cited by 30
Pham, T. H., Defaix, C., Nguyen, T. M. L., Mendez‐David, I., Tritschler, L., David, D. J. P., & Gardier, A. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172913 · Cited by 30
Ma, H., Li, J., Qiao, X., Zhang, Y., Hou, X.-J., Chen, H., Chen, H., Zhang, Y., & Li, Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01201-8 · Cited by 28
Fucich, E. A., Paredes, D., Saunders, M. O., & Morilak, D. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0635-17.2017 · Cited by 29
Hare, B. D., Pothula, S., Dileone, R., & Duman, R. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107947 · Cited by 26
Self-citationEffects of somatic treatments on suicidal ideation and completed suicides
Hawkins, E. M., Coryell, W. H., Leung, S., Parikh, S. V., Weston, C. L., Nestadt, P. S., Nürnberger, J. I., Kaplin, A. I., Kumar, A., Farooqui, A. A., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2381 · Cited by 28
An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions
Lewis, V., Rurak, G. M., Salmaso, N., & Aguilar‐Valles, A. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2023.12.004 · Cited by 31
Zhang, Y., Ma, H., Bai, Y., Hou, X., Yang, Y., Wang, G., & Li, Y. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00125 · Cited by 28
Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity
Barthas, F., Hu, M. Y., Siniscalchi, M. J., Ali, F., Mineur, Y. S., Picciotto, M. R., & Kwan, A. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.008 · Cited by 25
Tarrés-Gatius, M., Miquel-Rio, L., Campa, L., Artigas, F., & Castañé, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01110-y · Cited by 26
Kang, J. S., Baek, J. H., Jung, S., Chung, H. J., Lee, D., & Kim, H. J. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117978 · Cited by 25
Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites
Ago, Y., Yokoyama, R., Asano, S., & Hashimoto, H. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109313 · Cited by 24
Gasull-Camós, J., Martínez‐Torres, S., Tarrés-Gatius, M., Ozaita, A., Artigas, F., & Castañé, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.029 · Cited by 27
Prefrontal cortical circuits in anxiety and fear: an overview
Chen, Y., Hu, N.-Y., Yang, J., & Gao, T. (2022) · Frontiers of Medicine · doi:10.1007/s11684-022-0941-2 · Cited by 29
Pradhan, B., Parikh, T., Makani, R. D., & Sahoo, M. (2015) · Depression Research and Treatment · doi:10.1155/2015/842817 · Cited by 28
Sexually divergent cortical control of affective-autonomic integration
Wallace, T., Schaeuble, D., Pace, S. A., Schackmuth, M. K., Hentges, S. T., Chicco, A. J., & Myers, B. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105238 · Cited by 22
Gasull-Camós, J., Soto‐Montenegro, M. L., Casquero‐Veiga, M., Desco, M., Artigas, F., & Castañé, A. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx067 · Cited by 24
ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice
Shen, M., Lv, D., Liu, X., & Wang, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02290-5 · Cited by 22
Shi, X., Zhang, Q., Li, J., Liu, X., Zhang, Y., Huang, M., Fang, W., Xu, J., Yuan, T., Xiao, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109612 · Cited by 21
Jia, H., Zhang, M., Yiyun, C., Zhiguo, W., Su, Y., Feng, J., Zhu, N., Fang, Y., & Daihui, P. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.11.051 · Cited by 25
Synaptic Ensemble Underlying the Selection and Consolidation of Neuronal Circuits during Learning
Hoshiba, Y., Wada, T., & Hayashi‐Takagi, A. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00012 · Cited by 21
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Solecki, W., & Willner, P. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120967857 · Cited by 23
Optogenetics: A revolutionary approach for the study of depression
Fakhoury, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110094 · Cited by 21
Artigas, F., Celada, P., & Bortolozzi, A. A. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.01.005 · Cited by 20
Tian, Z. R., Dong, C., Zhang, K., Chang, L., & Hashimoto, K. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy072 · Cited by 18
Yoon, S. H., Song, W. S., Chung, G., Kim, S. J., & Kim, M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01294-z · Cited by 20
Benatti, B. M., Adiletta, A., Sgadó, P., Malgaroli, A., Ferro, M., & Lamanna, J. (2024) · Behavioral Sciences · doi:10.3390/bs14100882 · Cited by 23
Tosta, C. L., Silote, G. P., Fracalossi, M. P. D. S., Sartim, A. G., Andreatini, R., Joca, S. R. L., & Beijamini, V. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.039 · Cited by 19
Canto‐de‐Souza, L., Demetrovich, P. G., Plas, S. L., de Souza, R. R., Epperson, J. D., Wahlstrom, K. L., Nunes‐de‐Souza, R. L., LaLumiere, R. T., Planeta, C. S., & McIntyre, C. K. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.780326 · Cited by 18
Tang, X.-H., Diao, Y.-G., Ren, Z.-Y., Zang, Y., Zhang, G.-F., Wang, X., Duan, G., Shen, J.-C., Hashimoto, K., Zhou, Z., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109383 · Cited by 19
Ren, B., Yuan, Q., Cha, S., Liu, S.-Y. M., Zhang, J., & Guo, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05152-5 · Cited by 21
Alitalo, O., Saarreharju, R., Henter, I. D., Zarate, C. A., Kohtala, S., & Rantamäki, T. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102140 · Cited by 17
Amissah, R. Q., Basha, D., Bukhtiyarova, O., Timofeeva, E., & Timofeev, I. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113604 · Cited by 18
Chang, L., Zhang, K., Pu, Y., Qu, Y., Wang, S., Xiong, Z., Shirayama, Y., & Hashimoto, K. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01012-1 · Cited by 18
Neurochemical mechanisms of deep brain stimulation for depression in animal models
Campos, A. C. P., Pople, C. B., Silk, E., Surendrakumar, S., Rabelo, T. K., Meng, Y., Gouveia, F. V., Lipsman, N., Giacobbe, P., & Hamani, C. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.12.003 · Cited by 17
Liu, H., Wang, C., Lan, X., Li, W., Zhang, F., Fu, L., Ye, Y., Ning, Y., & Zhou, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1123797 · Cited by 16
Papp, M., Gruca, P., Litwa, E., Łasoń, M., Newman‐Tancredi, A., & Depoortère, R. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241254832 · Cited by 15
Jiang, T., Feng, M., Hutsell, A., & Lüscher, B. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02835-8 · Cited by 14
Bulin, S. E., Hohl, K., Paredes, D., Silva, J. D., & Morilak, D. A. (2019) · eNeuro · doi:10.1523/eneuro.0363-19.2019 · Cited by 15
Optogenetic investigation of neural mechanisms for alcohol-use disorder
Juarez, B., Liu, Y., Zhang, L., & Han, M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.05.005 · Cited by 15
CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity
Nguyen, T. M. L., McGowan, J. C., & Gardier, A. M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108936 · Cited by 17
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Solecki, W., & Willner, P. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211048281 · Cited by 15
Sun, R., Tang, M., Yang, D., Zhang, Y.-Y., Xu, Y.-H., Qiao, Y., Yu, B., Cao, S.-X., Wang, H., Huang, H.-Q., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102614 · Cited by 14
Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms
Thomas, A. M., & Duman, R. S. (2017) · Neuronal Signaling · doi:10.1042/ns20170010 · Cited by 14
Self-citationOptogenetics: What it has uncovered in potential pathways of depression
Cheng, Z., Cui, R., Ge, T., Yang, W., & Li, B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104596 · Cited by 14
Ye, L., Xiao, X., Xu, Y., Zheng, C., Chen, S. X., Luo, T., Li, Z., Du, Y., Yuan, Y., Li, L., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108984 · Cited by 14
López-Terrones, E., Paz, V., Campa, L., Conde-Berriozabal, S., Masana, M., Artigas, F., & Riga, M. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054891 · Cited by 13
Cortical–brainstem circuitry attenuates physiological stress reactivity
Pace, S. A., Lukinic, E., Wallace, T., McCartney, C., & Myers, B. (2024) · The Journal of Physiology · doi:10.1113/jp285627 · Cited by 12
Munguba, H., Srivastava, I., Gutzeit, V. A., Singh, A., Vijay, A., Kristt, M., Arefin, A., Thukral, S., Broichhagen, J., Stujenske, J. M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2025.01.002 · Cited by 13
Fernandes, A., & Li, Y.-W. (2017) · Brain Research · doi:10.1016/j.brainres.2017.05.008 · Cited by 12
Liu, J., Meng, F., Wang, W., Wu, M., Zhang, Y., Cui, M., Qiu, C., Hu, F., Zhao, D., Wang, D., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14293 · Cited by 11
Sex-specific prefrontal-hypothalamic control of behavior and stress responding
Schaeuble, D., Wallace, T., Pace, S. A., Hentges, S. T., & Myers, B. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106413 · Cited by 12
Abdulla, Z. I., Mineur, Y. S., Crouse, R. B., Etherington, I. M., Yousuf, H., Na, J. J., & Picciotto, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02003-0 · Cited by 11
Yoshioka, T., Yamada, D., Hagiwara, A., Kajino, K., Iio, K., Saitoh, T., Nagase, H., & Saitoh, A. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02814-z · Cited by 11
Papp, M., Gruca, P., Litwa, E., Łasoń, M., & Willner, P. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110715 · Cited by 13
Freitas, A. E., Heinrich, I. A., Moura, T. D. M., Fraga, D. B., Costa, A. P., Azevedo, D., Brocardo, P. S., Kaster, M. P., Leal, R. B., & Rodrigues, A. L. S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113398 · Cited by 11
Daniels, S., Mansari, M. E., Hamoudeh, R. A., & Blier, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1276309 · Cited by 11
Shiroma, P. R., THURAS, P. D., Polusny, M. A., Kehle‐Forbes, S., Disner, S. G., Pardo, J. V., Gilmore, C. S., Tolly, B., Voller, E. K., McManus, E. S., et al. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107569 · Cited by 10
Microtubule dynamics in cytoskeleton, neurodegenerative and psychiatric disease
Mortal, S. (2021) · STEMedicine · doi:10.37175/stemedicine.v2i6.81 · Cited by 10
Cao, Q., Wang, Z., Bai, W., Liu, T., & Zheng, X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1145721 · Cited by 10
Shen, M., Lv, D., Li, S., Zhang, Y., Wang, Z., Zhao, C., Chen, X., & Wang, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy324 · Cited by 10
Lei, Z., Lam, Y.-Y., Li, C.-H., Fu, Z., Ramkrishnan, A. S., Liu, S., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105578 · Cited by 10
Kramer, H. M., Hibicke, M., Middleton, J. W., Jaster, A. M., Kristensen, J. L., & Nichols, C. D. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02272-3 · Cited by 9
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets
Munguba, H., Arefin, A., Hasegawa, R., Posa, L., Romano, G. R., Peddada, T., Donatelle, A., Singh, A., Gutzeit, V. A., Vijay, A., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.006 · Cited by 10
Corticostriatal Suppression of Appetitive Pavlovian Conditioned Responding
Villaruel, F. R., Martins, M., & Chaudhri, N. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1664-21.2021 · Cited by 9
Chen, H., Chen, J., & Lan, J. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137805 · Cited by 9
Freitas, A. E., Feng, B., Woo, T., Galli, S., Baker, C., Ban, Y., Truong, J., Beyeler, A., & Zou, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-48257-6 · Cited by 9
Song, S., Zhai, X., Dai, J.-H., Lu, L.-L., Shan, C.-J., Hong, J. W., Cao, J., & Zhang, L. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.600555 · Cited by 9
Nashed, M. G., Waye, S., Hasan, S. M. N., Nguyen, D., Wiseman, M., Zhang, J., Lau, H., Dinesh, O. C., Raymond, R., Greig, I. R., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06045-w · Cited by 9
Wallace, T., & Myers, B. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.737960 · Cited by 8
Liang, R., Wang, L., Li, X., Liu, X., Chang, H., Xu, Q., Wang, Y., Xu, D., Liu, D., Yang, J., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad027 · Cited by 8
Zhang, P., You, W.-Y., Gao, Y., & Wu, X. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111008 · Cited by 8
López-Terrones, E., Celada, P., Riga, M. S., & Artigas, F. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab396 · Cited by 8
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Park, D., Lee, G., Lee, W.-G., Kim, B. S., Lee, Y., & Kim, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03100-2 · Cited by 11
Xing, Y., Zhang, A., Li, C., Han, J., wang, J., Luo, L., Chang, X., Tian, Z., & Bai, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03181-y · Cited by 7
Purple, R. J., Gupta, R., Thomas, C. W., Golden, C. T., Palomero‐Gallagher, N., Carhart-Harris, R. L., Froudist‐Walsh, S., & Jones, M. W. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03182-y · Cited by 10
Mahmud, A., & Karaman, M. A. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1843871 · Cited by 7
Silva-Cardoso, G. K., & Nobre, M. J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03300-6 · Cited by 6
Waye, S., Dinesh, O. C., Hasan, S. M. N., Conway, J. D., Raymond, R., Nóbrega, J. N., Blundell, J. J., & Bambico, F. R. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211000765 · Cited by 7
Metadata
- Authors
- Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S.
- Affiliations
- Yale University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-06-08
- Volume
- 112
- Issue
- 26
- Pages
- 8106-8111
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4491758
- OpenAlex
- W1812482953
- Cited by
- 265
- References
- 44
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 27 · 2023: 22 · 2022: 25 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 24 · 2017: 22 · 2016: 13 · 2015: 7
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (R37MH45481, R01MH93897)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ketamine, antidepressant effects, optogenetic stimulation, infralimbic cortex, anxiolytic effects, neural inactivation, layer 5 pyramidal neurons, synaptic plasticity, depression
- MeSH terms
- Animals, Antidepressive Agents, Behavior, Animal, Ketamine, Limbic System, Male, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, Optogenetics
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