Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

Hallmarks of Cancer: The Next Generation

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The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited

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Dissemination and growth of cancer cells in metastatic sites

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Tumor Metastasis: Molecular Insights and Evolving Paradigms

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Crossing the endothelial barrier during metastasis

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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

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Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment

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Microfluidic-based biomimetic models for life science research

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Bone microphysiological models for biomedical research

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3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application

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Manipulation of cancer cells in a sessile droplet via travelling surface acoustic waves

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Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases

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Reduction of breast cancer extravasation via vibration activated osteocyte regulation

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High‐Throughput Blood‐ and Lymph‐Capillaries with Open‐Ended Pores Which Allow the Transport of Drugs and Cells

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Complementary, Semiautomated Methods for Creating Multidimensional PEG-Based Biomaterials

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Deciphering the relative contribution of vascular inflammation and blood rheology in metastatic spreading

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Microfluidic analysis of heterotypic cellular interactions: A review of techniques and applications

Sakthivel, K., O’Brien, A., Kim, K., & Hoorfar, M. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.03.026 · Cited by 22

Engineering Patient-on-a-Chip Models for Personalized Cancer Medicine

Caballero, D., Reis, R. L., & Kundu, S. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36588-2_4 · Cited by 21

Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma

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Desmoplastic Reaction in 3D‐Pancreatic Cancer Tissues Suppresses Molecular Permeability

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Progress in mimicking brain microenvironments to understand and treat neurological disorders

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Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip

Zhou, L., Liu, L., Chang, M. A., Ma, C., Chen, W., & Chen, P. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115064 · Cited by 20

On‐Chip Reconstitution of Uniformly Shear‐Sensing 3D Matrix‐Embedded Multicellular Blood Microvessel

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Engineering Heterogeneous Tumor Models for Biomedical Applications

Wu, Z., Huang, D., Wang, J., Zhao, Y., Sun, W., & Shen, X. (2023) · Advanced Science · doi:10.1002/advs.202304160 · Cited by 19

Angiogenesis‐Enabled Human Ovarian Tumor Microenvironment‐Chip Evaluates Pathophysiology of Platelets in Microcirculation

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Embracing Mechanobiology in Next Generation Organ-On-A-Chip Models of Bone Metastasis

Slay, E., Meldrum, F. C., Pensabene, V., & Amer, M. H. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.722501 · Cited by 20

Multiscale engineered human skeletal muscles with perfusable vasculature and microvascular network recapitulating the fluid compartments

Kim, H., Osaki, T., Kamm, R. D., & Asada, H. H. (2022) · Biofabrication · doi:10.1088/1758-5090/ac933d · Cited by 16

Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer

Perrin, L., & Gligorijevic, B. (2022) · Physical Biology · doi:10.1088/1478-3975/aca0d8 · Cited by 21

Translational Nanomedicines Across Human Reproductive Organs Modeling on Microfluidic Chips: State-of-the-Art and Future Prospects

Sood, A., Kumar, A., Gupta, V. K., Kim, C. M., & Han, S. S. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01080 · Cited by 21

Engineered Vasculature for Cancer Research and Regenerative Medicine

Nguyen, H. T., Peirsman, A., Tirpáková, Z., Mandal, K., Vanlauwe, F., Maity, S., Kawakita, S., Khorsandi, D., Herculano, R. D., Umemura, C., et al. (2023) · Micromachines · doi:10.3390/mi14050978 · Cited by 19

A Microfluidic Organ-On-A-Chip: Into the Next Decade of Bone Tissue Engineering Applied in Dentistry

Syahruddin, M. H., Anggraeni, R., & Ana, I. D. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0061 · Cited by 20

You-on-a-chip’ for precision medicine

Low, L. A., & Tagle, D. A. (2018) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2018.1456333 · Cited by 18

Revolutionizing bone healing: the role of 3D models

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Vascularizing organoids-on-chip for perfused and personalized models

Menzani, B., Gea, P. D., Gidrol, X., & Tubbs, E. (2026) · Lab on a Chip · doi:10.1039/d5lc00890e · Cited by 20

Cancer Cell Invasion and Metastasis in Zebrafish Models (Danio rerio)

Martinez, S. A., Berens, E. B., Sharif, G. M., Glasgow, E. F., & Wellstein, A. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1350-4_1 · Cited by 18

Laser-based fabrication of 3D hydrogel constructs using bessel beams

Liew, W. L. A., & Zhang, Y. (2018) · Bioprinting · doi:10.1016/j.bprint.2018.02.004 · Cited by 18

3D Engineering of Ocular Tissues for Disease Modeling and Drug Testing

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Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio)

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Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip

Li, Y., Wu, Y., Liu, Y., Deng, Q., Mak, M., & Yang, X. (2019) · Nanoscale · doi:10.1039/c9nr03622a · Cited by 17

Modelling skeletal pain harnessing tissue engineering

Iafrate, L., Benedetti, M. C., Donsante, S., Rosa, A., Corsi, A., Oreffo, R. O. C., Riminucci, M., Ruocco, G., Scognamiglio, C., & Cidonio, G. (2022) · In vitro models · doi:10.1007/s44164-022-00028-7 · Cited by 17

Spatially patterned 3D model mimics key features of cancer metastasis to bone

Díaz, E. C. G., Tai, M., Monette, C. E., Wu, J. Y., & Yang, F. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122163 · Cited by 17

Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

Farooqi, M. A., Kang, C.-U., & Choi, K. H. (2023) · ACS Omega · doi:10.1021/acsomega.3c03155 · Cited by 18

Model Systems to Study the Mechanism of Vascular Aging

van der Linden, J., Trap, L., Scherer, C. V., Roks, A. J. M., Danser, A. H. J., van der Pluijm, I., & Cheng, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015379 · Cited by 17

Review Article: Capturing the physiological complexity of the brain's neuro-vascular unit in vitro

Heidari, H., & Taylor, H. (2018) · Biomicrofluidics · doi:10.1063/1.5045126 · Cited by 18

Leaf-Inspired Authentically Complex Microvascular Networks for Deciphering Biological Transport Process

Miali, M. E., Colasuonno, M., Surdo, S., Palomba, R., Pereira, R. C., Rondanina, E., Diaspro, A., Pascazio, G., & Decuzzi, P. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09453 · Cited by 17

The neurotoxicity of Nε-(carboxymethyl)lysine in food processing by a study based on animal and organotypic cell culture

Wu, Y., Li, Y., Zheng, L., Wang, P., Liu, Y., Wu, Y., & Gong, Z. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.110077 · Cited by 17

Organotypic Modeling of the Tumor Landscape

Haykal, M. M., Nahmias, C., Varon, C., & Martin, O. C. B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.606039 · Cited by 18

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Ninno, A. D., Bertani, F. R., Gerardino, A., Schiavoni, G., Musella, M., Galassi, C., Mattei, F., Sistigu, A., & Businaro, L. (2021) · Journal of Visualized Experiments · doi:10.3791/61895 · Cited by 17

3D In Vitro Platform for Cell and Explant Culture in Liquid-like Solids

Nguyen, D., Famiglietti, J. E., Smolchek, R. A., Dupee, Z., Diodati, N. G., Pedro, D. I., Urueña, J. M., Schaller, M. A., & Sawyer, W. G. (2022) · Cells · doi:10.3390/cells11060967 · Cited by 17

Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs

Xiao, Y., Liu, C., Chen, Z., Blatchley, M. R., Kim, D., Zhou, J., Xu, M., Gerecht, S., & Fan, R. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900089 · Cited by 18

Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian Cancer

Plesselova, S., Calar, K., Axemaker, H., Sahly, E., Bhagia, A., Faragher, J. L., Fink, D. M., & de la Puente, P. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00817-y · Cited by 18

ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid‐Endothelial Interactions

Ro, J., Kim, J., Park, J., Choi, Y., & Cho, Y. (2025) · Advanced Science · doi:10.1002/advs.202410659 · Cited by 16

In Vitro Co-culture of Fibroblast and Endothelial Cells to Assess Angiogenesis

Odell, A. F., & Mannion, A. J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2059-5_21 · Cited by 16

A microphysiological system-based potency bioassay for the functional quality assessment of mesenchymal stromal cells targeting vasculogenesis

Lam, J., Lee, B., Yu, J., Kwee, B. J., Kim, Y., Kim, J., Choi, Y., Yoon, J. S., Kim, Y., Baek, K., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121826 · Cited by 16

In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening

Ngo, H. T., Amartumur, S., Tran, V. T. A., Tran, M., Diep, Y. N., Cho, H., & Lee, L. P. (2023) · Biosensors · doi:10.3390/bios13020231 · Cited by 15

Engineering prostate cancer in vitro: what does it take?

Buskin, A., Scott, E., Nelson, R., Gaughan, L., Robson, C. N., Heer, R., & Hepburn, A. C. (2023) · Oncogene · doi:10.1038/s41388-023-02776-6 · Cited by 17

Cardiovascular human organ‐on‐a‐chip platform for disease modeling, drug development, and personalized therapy

Khanna, A., Oropeza, B. P., & Huang, N. F. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37602 · Cited by 20

Recapitulating and Deciphering Tumor Microenvironment by Using 3D Printed Plastic Brick–Like Microfluidic Cell Patterning

Liu, Y., Liu, Y., Zheng, X. S., Zhao, L., & Zhang, X. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901713 · Cited by 16

Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries

Jeong, D. P., Hall, E., Neu, E., & Hanjaya‐Putra, D. (2022) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-022-00730-2 · Cited by 17

Probing the response of lung tumor cells to inflammatory microvascular endothelial cells on fluidic microdevice

Xu, H. M., Li, Z., Guo, Y., Peng, X., & Qin, J. (2016) · Electrophoresis · doi:10.1002/elps.201600278 · Cited by 16

Kernel-Based Microfluidic Constriction Assay for Tumor Sample Identification

Ren, X., Ghassemi, P., KANAAN, Y. M., Naab, T. J., Copeland, R., DeWitty, R. L., Kim, I., Strobl, J. S., & Agah, M. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00301 · Cited by 16

Vascular microphysiological systems (MPS): biologically relevant and potent models

Breuil, L., Kitada, A., Yadav, S., Zhou, H., Fujimoto, K., & Yokokawa, R. (2025) · Lab on a Chip · doi:10.1039/d5lc00014a · Cited by 15

Reductionist Three-Dimensional Tumor Microenvironment Models in Synthetic Hydrogels

Katz, R. R., & West, J. L. (2022) · Cancers · doi:10.3390/cancers14051225 · Cited by 15

In Vitro Human Cancer Models for Biomedical Applications

Choi, J. R., Kozalak, G., di Bari, I., Babar, Q., Niknam, Z., Rasmi, Y., & Yong, K. W. (2022) · Cancers · doi:10.3390/cancers14092284 · Cited by 16

Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments

Guo, Z., Yang, C., Chien, C., Selth, L. A., Bagnaninchi, P., & Thierry, B. (2022) · Small Methods · doi:10.1002/smtd.202200471 · Cited by 15

3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay

Zhang, Y., Jiang, F., Zhao, Y. C., Cho, A., Fang, G., Cox, C. D., Zreiqat, H., Lu, Z. F., Lu, H., & Ju, L. A. (2023) · Biomedical Materials · doi:10.1088/1748-605x/ace7a4 · Cited by 15

Engineering models of head and neck and oral cancers on-a-chip

Sousa, M. G. D. C., Vignolo, S. M., França, C. M., Mereness, J. A., Fraga, M. A. A., Silva‐Sousa, A. C., Benoit, D. S. W., & Bertassoni, L. E. (2024) · Biomicrofluidics · doi:10.1063/5.0186722 · Cited by 14

Progress towards understanding heterotypic interactions in multi-culture models of breast cancer

Regier, M. C., Alarid, E. T., & Beebe, D. J. (2016) · Integrative Biology · doi:10.1039/c6ib00001k · Cited by 17

A Near‐Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High‐Throughput Screening via 3D‐Blood Vessel Models

Sisak, M. A. A., Louis, F., Aoki, I., Lee, S. H., Chang, Y., & Matsusaki, M. (2021) · Small Methods · doi:10.1002/smtd.202100338 · Cited by 15

Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes

Arrigoni, C., Ostano, P., Bersini, S., Crippa, M., Colombo, M. V., Gilardi, M., Zagra, L., Grand, M. M., Gregnanin, I., Ghilardi, C., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04515-9 · Cited by 15

Self-assembly of vascularized tissue to support tumor explants in vitro

Bazou, D., Maimon, N., Gruionu, G., & Munn, L. L. (2016) · Integrative Biology · doi:10.1039/c6ib00108d · Cited by 16

Bioprinting of three-dimensional culture models and organ-on-a-chip systems

Huang, Y. Y. S., Zhang, D., & Liu, Y. (2017) · MRS Bulletin · doi:10.1557/mrs.2017.163 · Cited by 15

Bioengineering Human Bone Marrow in Liquefied Micro-Compartments: A Promising Approach for the Recapitulation of Osteovascular Niches

Oliveira, C. S., Nadine, S., Gomes, M. C., Correia, C. R., & Mano, J. F. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.07.001 · Cited by 15

Microfluidic outer blood–retinal barrier model for inducing wet age-related macular degeneration by hypoxic stress

Lee, S., Kim, S., & Jeon, J. S. (2022) · Lab on a Chip · doi:10.1039/d2lc00672c · Cited by 14

Building Blood Vessel Chips with Enhanced Physiological Relevance

Mu, X., Gerhard‐Herman, M. D., & Zhang, Y. S. (2023) · Advanced Materials Technologies · doi:10.1002/admt.202201778 · Cited by 15

Endothelial cells metabolically regulate breast cancer invasion toward a microvessel

Tan, M. L., Jenkins-Johnston, N., Huang, S., Schutrum, B. E., Vadhin, S., Adhikari, A., Williams, R. M., Zipfel, W. R., Lammerding, J., Varner, J. D., et al. (2023) · APL Bioengineering · doi:10.1063/5.0171109 · Cited by 14

A 3D In Vitro Triculture Hybrid Model Recapitulating Tumor Stromal Interaction of Triple‐Negative Breast Cancer as a High Throughput Anticancer Drug Screening Platform

Jaiswal, C., & Mandal, B. B. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202300450 · Cited by 16

Bioengineering approaches for the endometrial research and application

Dai, W., Liang, J., Guo, R., Zhao, Z., Na, Z., Xu, D., & Li, D. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101045 · Cited by 15

Biomaterials and Microfluidics for Drug Discovery and Development

Carvalho, M. R., Truckenmüller, R. K., Reis, R. L., & Oliveira, J. M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36588-2_8 · Cited by 14

Developments of microfluidics for orthopedic applications: A review

Sun, M., Gong, J., Cui, W., Li, C., Yu, M., Ye, H., Cui, Z., Chen, J., He, Y., Liu, A., et al. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.07.001 · Cited by 14

Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation

Watson, S. A., Javanmardi, Y., Zanieri, L., Shahreza, S., Ragazzini, R., Bonfanti, P., & Moeendarbary, E. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10454 · Cited by 13

Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro

Morgan, M. M., Schuler, L. A., Ciciliano, J. C., Johnson, B. P., Alarid, E. T., & Beebe, D. J. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa002 · Cited by 14

Advanced in vitro models for renal cell carcinoma therapy design

Mieville, V., Griffioen, A. W., Benamran, D. A., & Nowak-Sliwinska, P. M. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188942 · Cited by 12

Mammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones

Moccia, C., Cherubini, M., Fortea, M., Akinbote, A., Padmanaban, P., Beltrán-Sastre, V., & Haase, K. (2023) · Advanced Science · doi:10.1002/advs.202302561 · Cited by 13

Complex or not too complex? One size does not fit all in next generation microphysiological systems

Bersini, S., Arrigoni, C., Talò, G., Candrian, C., & Moretti, M. (2024) · iScience · doi:10.1016/j.isci.2024.109199 · Cited by 13

Differential osteo-specific invasion of patient-derived cancer cells in a microfluidic co-culture model

Sudhakaran, S. V., Mehta, V., Jilla, S., & Rath, S. N. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151202 · Cited by 13

Microfluidic Reconstitution of Tumor Microenvironment for Nanomedical Applications

Oh, H. J., Kim, J., Kim, H., Choi, N., & Chung, S. H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002122 · Cited by 13

Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells

Mayo, V., Bowles, A. C., Wubker, L., Ortiz, I., Cordoves, A. M., Côté, R. J., Correa, D., & Agarwal, A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220971599 · Cited by 15

Re-Use of Established Drugs for Anti-Metastatic Indications

Entschladen, F., Thyssen, D., & Drell, D. (2016) · Cells · doi:10.3390/cells5010002 · Cited by 12

Modeling adaptive drug resistance of colorectal cancer and therapeutic interventions with tumor spheroids

Lamichhane, A., Thakuri, P. S., Nejad, P. R., & Tavana, H. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211014185 · Cited by 13

Microphysiological systems to study tumor-stroma interactions in brain cancer

Neves, E. R., Harley, B. A. C., & Pedrón, S. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.012 · Cited by 12

Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization

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Stochastic to Deterministic: A Straightforward Approach to Create Serially Perfusable Multiscale Capillary Beds

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