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Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
Open accessAbstract
Significance: The cancer biology seed-and-soil paradigm recognizes the existence of organ-specific patterns of metastasization that drive the spread of selected primary tumors toward specific secondary loci. However, despite efforts to model the organotypic microenvironment, the organ specificity of cancer metastases needs to be elucidated. The relevance of this study lies in the generation of a human vascularized organ-specific microenvironment, which can be used to investigate and tune the extravasation process of metastatic tumor cells. Furthermore, beyond mimicking the pro- or antimetastatic signatures of different microenvironments, our microfluidic model provides insights into different properties of organ-specific endothelia. This study paves the way toward advanced in vitro models to screen for highly tailored organ-specific therapeutics and investigate key molecular pathways involved in organ-specific metastases.
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“Through this, it was shown that adenosine played an important role in promoting tumor cells extravasation.”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [98]
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“By blocking A3 adenosine receptors, cancer cells were observed to have a reduced extravasation rate.”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [98]
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“Endothelial cells displayed morphological features similar to in vivo conditions, contrasting to poorly aligned cells grown in 2D cultures or deprived of fl ow.”
From 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions (2021) · cites this paper as [78]
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“This micro fl uidic device not only promoted the perfusable culture of four different cells types but also proved to be an appropriate platform for monitoring cancer cell extravasation in real time.”
From 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions (2021) · cites this paper as [78]
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“The results indicated inhibitory role of adenosine on extravasation as blocking A3 adenosine receptors increased extravasation rates of breast cancer cells into the myoblast, mimicking microenvironments compared with untreated cells [57].”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [57]
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“Fortunately, with the development of biofabrication techniques, microfluidic and 3D bioprinting technologies have been employed to create more in vivo‐like perfusable 3D tumor models in the biomimetic matrix.[ 72 , 161 ]”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [161]
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“CoC models can be applied to elucidate these effects, and researchers have developed vascularized CoC models to study extravasation to bone [74][75][76], brain [77,78], and other organs [79]”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [75]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 1×
“Although circulatory patterns and flow rates may play some role in cancer cell dissemination, it appears that the organ specificity of metastases is primary due to the cross-talk between specific cancer cells and biologically unique tissues: the seed-and-soil paradigm (4).”
BackgroundDissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 4,018
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Metastasis: from dissemination to organ-specific colonization
Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2622 · Cited by 2,716
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,594
Tumor Self-Seeding by Circulating Cancer Cells
Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D. X., Zhang, X. H.-F., Norton, L., & Massagué, J. (2009) · Cell · doi:10.1016/j.cell.2009.11.025 · Cited by 1,335
Crossing the endothelial barrier during metastasis
Reymond, N., d'Água, B. B., & Ridley, A. J. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3628 · Cited by 922
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872
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Dávila, S., Martín–Asensio, A., Diego, E. S., Hernández, J. J., & Rodríguez, I. (2025) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2025.102863 · Cited by 3
Shao, H., & Young, E. W. K. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01713 · Cited by 3
Ayensa-Jiménez, J., Doweidar, M. H., Doblaré, M., & Gaffney, E. A. (2023) · Bulletin of Mathematical Biology · doi:10.1007/s11538-023-01194-9 · Cited by 3
Investigation of tumour environments through advancements in microtechnology and nanotechnology
Liu, Z., Fan, Y. L., Cui, M., Wang, X., & Zhao, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117230 · Cited by 3
Aratake, S., & Funamoto, K. (2024) · Microfluidics and Nanofluidics · doi:10.1007/s10404-024-02768-2 · Cited by 3
Guo, J., Wang, M., Xue, S., Wang, Q., Wang, M., Sun, Z., Feng, J., & Feng, Y. (2024) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2024.109361 · Cited by 3
Tumor vascular normalization by B7-H3 blockade augments T lymphocyte-mediated antitumor immunity
Dai, X., Cao, B., Liu, X., Meng, W., Qiu, Y., Sun, Y., Zhang, L., Li, D., Liu, Z., Li, D., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177334 · Cited by 3
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Dogan, E., Salemizadehparizi, F., Çeçen, B., & Miri, A. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85671-3.00006-3 · Cited by 3
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Munn, L. L., & Bazou, D. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3056-3_12 · Cited by 3
Gupta, B., Malviya, R., Srivastava, S., Ahmad, I. S., Rab, S. O., & Uniyal, P. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128305296240523112043 · Cited by 3
Bioengineered in vitro Vascular Models for Applications in Interventional Radiology
Li, X., Basri, S. M. M., Sheth, R. A., Wang, X., & Zhang, Y. S. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180416114325 · Cited by 3
Elitaş, M., & Zeinali, S. (2016) · International Journal of Cancer Studies & Research · doi:10.19070/2167-9118-si05001 · Cited by 3
Study of diffusive- and convective-transport mediated microtumor growth in a controlled microchamber
Hsu, Y., Liu, W., Wu, T.-H., Lee, C. J.-T., Chen, Y.-H., & Li, P. (2019) · Biomedical Microdevices · doi:10.1007/s10544-018-0356-7 · Cited by 3
Tissue-engineered 3D cancer microenvironment for screening therapeutics
Li, N. T., Co, I. L., Landon‐Brace, N., Latour, S., & McGuigan, A. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00019-8 · Cited by 4
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Blache, U., Guerrero, J., Güven, S., Klar, A. S., & Scherberich, A. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-319-54586-8_9 · Cited by 3
Ghoshal, D., Petersen, I., Ringquist, R., Kramer, L., Bhatia, E., Hu, T., Richard, A., Park, R., Corbin, J., Agarwal, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.08.588601 · Cited by 4
Hwang, S., Lee, D., Lee, Y.-G., Ahn, J., & Kang, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102240 · Cited by 3
Wu, M., Xu, D., Dou, X., Zhou, Y., Lu, J., & Ge, Q. (2026) · Cell Signaling Inflammation & Disease · doi:10.1186/s44505-026-00004-y · Cited by 2
Organ-specific colonization and niche remodeling in a human tissue model of metastasis
Chramiec, A. G., Baldassarri, I., Öztürk, E., Tavakol, D. N., Wang, M. C., Summers, M., Yeager, K. J., Zhuang, R. Z., Srivastava, A., Tagore, S., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adv6871 · Cited by 2
Easy-to-use microfluidic chip for long-term 3D-cell cultures
Bunge, F., van den Driesche, S., & Vellekoop, M. J. (2017) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2265734 · Cited by 2
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Ribeiro, P. S. S., Leitão, L., Monteiro, A. C., Bortolin, A., Moura, B. S., Lamghari, M., & Neto, E. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.015 · Cited by 4
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WenTing, L. I. U., FuQiang, N. I. E., & HongMei, C. H. E. N. (2015) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-01055 · Cited by 1
Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research
Campanile, M., Bettinelli, L., Cerutti, C., & Spinetti, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1261849 · Cited by 2
Huniadi, M., Nosálová, N., Almášiová, V., Horňáková, Ľ., Valenčáková-Agyagosová, A., Hudáková, N., & Cizkova, D. (2024) · Cells · doi:10.3390/cells13080695 · Cited by 3
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Kim, J., Ro, J., & Cho, Y. (2024) · Biomicrofluidics · doi:10.1063/5.0220840 · Cited by 2
Mechanical interaction between a hydrogel and an embedded cell in biomicrofluidic applications
Li, L., Zhang, J., Yue, P., & Feng, J. J. (2025) · Biomicrofluidics · doi:10.1063/5.0263344 · Cited by 2
Ayensa-Jiménez, J., Pérez-Aliacar, M., Doweidar, M. H., Gaffney, E. A., & Doblaré, M. (2025) · Archives of Computational Methods in Engineering · doi:10.1007/s11831-025-10291-y · Cited by 2
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Devadas, D., & Young, E. W. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-30019-1_15 · Cited by 2
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Kundu, B., Reis, R. L., & Kundu, S. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00009-5 · Cited by 2
Nairon, K. G., & Skardal, A. (2021) · Future Drug Discovery · doi:10.4155/fdd-2020-0034 · Cited by 3
Tirella, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_28 · Cited by 2
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Jain, K. K. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2553-7_10 · Cited by 2
Ozbolat, I. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803010-3.00009-3 · Cited by 2
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Bergevin, M. D., Boczula, A. E., Caruso, L.-L., Persson, H., Simmons, C. A., & Moriarty, T. J. (2022) · Cellular Microbiology · doi:10.1155/2022/3130361 · Cited by 2
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Chang, C.-S., Holter, J. C., & Song, J. W. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00252 · Cited by 2
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Мыльникова, А. Н., Kolesov, D. V., Московцев, А. А., Соколовская, А. А., Yurkiv, V. A., & Kubatiev, A. A. (2018) · Nauchno-prakticheskii zhurnal «Patogenez» · doi:10.25557/gm.2018.4.9743 · Cited by 2
Perfusion-based 3D tumor-on-chip devices for anticancer drug testing
Dhiman, N., & Rath, S. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00016-2 · Cited by 2
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Hajal, C. (2018) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 2
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Udayasuryan, B., Slade, D. J., & Verbridge, S. S. (2019) · doi:10.1002/9783527818341.ch9 · Cited by 2
Yildirir, B. F., Bati‐Ayaz, G., Tahmaz, İ., Bilgen, M., Pesen‐Okvur, D., & Yalcin-Ozuysal, Ö. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.25.312793 · Cited by 2
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Cha, C. (2022) · doi:10.1002/9783527831371.ch7 · Cited by 2
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Wei, L., Li, Z., Zhong, N., Cao, L., Wang, G.-R., Xiao, Y., Cai, B., Liu, B., & Bu, L. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400052 · Cited by 1
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Li, X., Khan, S., Wang, L., Chen, Y., Fang, X., Zhou, Y., & Wang, Y. I. (2025) · Biomedical Materials · doi:10.1088/1748-605x/adebd0 · Cited by 1
Sivéry, A., Woesteland, F., Duval, J., Denoulet, M., Soncin, F., Bourhis, X. L., Treizebre, A., & Lagadec, C. H. (2025) · Biomicrofluidics · doi:10.1063/5.0279981 · Cited by 1
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Jubelin, C., Golias, M., Cochonneau, D., Muñoz-García, J., & Heymann, D. (2025) · Bulletin du Cancer · doi:10.1016/j.bulcan.2025.09.004 · Cited by 1
Heras, U., Pardo-Sánchez, J. M., Fallert, L., de Aberasturi, D. J., Mitxelena‐Iribarren, O., & Cipitria, A. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070824-124153 · Cited by 1
Sokoliuk, D., Bouhaya, R., Haeger, P., Godthardt, K., Fetting, D., Spiecker, L., Spiecker, H., Rockenbach, A., Rothe, H., Liefeith, K., et al. (2026) · Engineering in Life Sciences · doi:10.1002/elsc.70059 · Cited by 1
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Razavi, M. S., Lei, P., Amoozgar, Z., O’Melia, M. J., Roh, K., Leartprapun, N., Nadkarni, S. K., Baish, J. W., Padera, T. P., & Munn, L. L. (2026) · Scientific Reports · doi:10.1038/s41598-026-39167-2 · Cited by 8
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Guo, Z., Tang, X., Xiao, S., Chen, G., Su, T., Wang, A. Y., Chen, R., Chen, C., Yang, Z., Qi, Z., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03986-8 · Cited by 1
Jaiswal, C., Bhar, B., Sugihara, S., & Mandal, B. B. (2026) · Small · doi:10.1002/smll.202513199 · Cited by 1
Tong, Y.-W., Chen, A. C., Pai, P., & Lei, K. F. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00457 · Cited by 1
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Chen, Y., Phillips, K. R., Alsberg, E., Angelini, T. E., Annabi, N., Atala, A., Bandyopadhyay, A. K., Bellan, L. M., Bertassoni, L. E., Blazeski, A., et al. (2026) · Bio-Design and Manufacturing · doi:10.1631/bdm.2600246 · Cited by 2
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Garcia, A. R., & Brito, M. A. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2023_154 · Cited by 1
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Adams, F., Zimmermann, C. M., Luciani, P., & Merkel, O. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822482-3.00010-5 · Cited by 1
Krattiger, L. A., Mitsi, M., Simona, B. R., & Ehrbar, M. (2023) · Journal of Visualized Experiments · doi:10.3791/65413 · Cited by 1
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Joddar, B., Sieminski, A. L., Hogrebe, N. J., Tennant, C. J., & Gooch, K. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.09820-9 · Cited by 2
Microvascular Networks and Models, In vitro Formation
Blache, U., Guerrero, J., Güven, S., Klar, A. S., & Scherberich, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-21056-8_9-1 · Cited by 2
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Ayensa-Jiménez, J., Doweidar, M. H., Ranđelović, T., Fernández, L. J., Oliván, S., Ochoa, I., & Doblaré, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816390-0.00016-9 · Cited by 1
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Lin, C.-Y., Xu, L., & You, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00067-0 · Cited by 1
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Mandenius, C. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-232-7 · Cited by 1
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Tran, D. Q. (2017) · doi:10.32657/10356/69578 · Cited by 1
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Liew, A. W. L. (2020) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/136772 · Cited by 1
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Shah, L., Latif, A., Williams, K., Mancuso, E., & Tirella, A. (2022) · bioRxiv · doi:10.1101/2022.07.22.500985
Huang, C., & Lei, K. F. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4090437 · Cited by 1
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Shin, Y., Han, S., Jeong, H. E., Kim, J. A., Jeon, J. S., & Chung, S. H. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139939751.019
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Pence, J. C. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Bergevin, M. D. (2017) · TSpace (University of Toronto)
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Cho, M. J., Chi, B. H., Kim, M. J., Whang, Y. M., & Chang, I. H. (2017) · Journal of Urologic Oncology · doi:10.22465/kjuo.2017.15.3.103
Kurokawa, Y. K. (2017) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7db818f
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Nañez, A., McBride, H. J., Long, T., Steffen, J. M., & Steffen, M. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95618-6
Hosic, S. (2019) · Digital Repository Service (Northeastern University) · doi:10.17760/d20317949
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Torisawa, Y. (2019) · Drug Delivery System · doi:10.2745/dds.34.268
King, C. T. (2019) · Louisiana State University · doi:10.31390/gradschool_theses.5039
Albers, H. J. (2020) · doi:10.3990/1.9789036549707
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Grosh, D., Wulftange, W. J., Robey, R. W., Pohida, T. J., Morgan, N. Y., & Gottesman, M. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00027-7
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Guo, Z., Yang, C., Chien, C., Selth, L. A., Bagnaninchi, P., & Thierry, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.26.457857
do Amaral, R. L. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2020.tde-21092021-055958
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França, C. M., Mansoorifar, A., Athirasala, A., Subbiah, R., Tahayeri, A., & Bertassoni, L. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.05.487240
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邓, 瑶. (2020) · Advances in Clinical Medicine · doi:10.12677/acm.2020.1012458
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(2023) · International Journal of Nanotechnology and Nanomedicine · doi:10.33140/ijnn.08.01.07
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Metadata
- Authors
- Jeon, J. S., Bersini, S., Gilardi, M., Dubini, G., Charest, J. L., Moretti, M., & Kamm, R. D.
- Affiliations
- Massachusetts Institute of Technology (US)
- IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
- Politecnico di Milano (IT)
- Draper Laboratory (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-12-18
- Volume
- 112
- Issue
- 1
- Pages
- 214-219
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4291627
- OpenAlex
- W2081560083
- Semantic Scholar
- f475569e9cefbccc34378d56e185a60e479f18b8
- Cited by
- 723
- References
- 44
- Citations by year
- 2026: 28 · 2025: 44 · 2024: 53 · 2023: 71 · 2022: 79 · 2021: 85 · 2020: 83 · 2019: 71 · 2018: 77 · 2017: 59 · 2016: 52 · 2015: 21
- FWCI
- 22.85
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-02-02)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- HHS | NIH | National Cancer Institute (R33 CA174550-01, R21 CA140096)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- breast cancer, tumor cell extravasation, organ-specific metastasis, microvascular permeability, A3 adenosine receptor, drug screening, personalized medicine
- MeSH terms
- Adenosine, Animals, Breast Neoplasms, Capillary Permeability, Extravasation of Diagnostic and Therapeutic Materials, Female, Humans, Stress, Mechanical, Shear Strength, Microfluidics, Cell Line, Tumor, Mice, Microvessels, Cellular Microenvironment, Human Umbilical Vein Endothelial Cells
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