The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Suppression of cancer relapse and metastasis by inhibiting cancer stemness
Open accessAbstract
Significance: Current cancer treatments ultimately fail owing to metastasis and relapse. The discovery of therapeutic approaches that counteract relapse and metastasis is, therefore, extremely important for advancing cancer medicine. Hypermalignant cancer cells, termed cancer stem cells or stemness-high cancer cells, have been isolated from patients with a variety of tumor types and found to be highly malignant, tumorigenic, and resistant to chemotherapies. Our data that BBI608, a cancer stemness inhibitor in clinical development, effectively blocks cancer relapse and metastasis in xenografted human cancers, suggest targeting cancer stemness as a novel approach to develop the next generation of cancer therapeutics to suppress cancer relapse and metastasis.
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Cites
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Cited by
Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance
Chang, J. C. (2016) · Medicine · doi:10.1097/md.0000000000004766 · Cited by 435
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A framework for the development of effective anti-metastatic agents
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The immune system and cancer evasion strategies: therapeutic concepts
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Metadata
- Authors
- Li, Y., Rogoff, H. A., Keates, S., Gao, Y., Murikipudi, S., Mikule, K., Leggett, D., Li, W., Pardee, A. B., & Li, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-01-20
- Volume
- 112
- Issue
- 6
- Pages
- 1839-1844
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2127396827
- Cited by
- 458
- References
- 45
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, Y., Rogoff, H. A., Keates, S., Gao, Y., Murikipudi, S., Mikule, K., Leggett, D., Li, W., Pardee, A. B., & Li, C. J. (2015). Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1424171112
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