The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
Open accessAbstract
Significance: Self-administered insulin is the most important therapeutic to provide control over blood glucose levels for patients with type-1 diabetes. However, standard insulin therapy introduces a number of complications and subsequent issues with control of blood glucose levels. Here, we prepared a derivative of insulin with a molecular switch to provide glucose-mediated activation of the insulin molecule, toward the generation of more autonomous therapy with improved blood glucose control. This modified insulin, when administered in a diabetic mouse model, restores blood glucose levels following a glucose challenge (i.e., a simulated meal) faster than both standard insulin and a clinically used long-lasting insulin derivative.
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Citations
Cites
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Hirsch, I. B. (2005) · New England Journal of Medicine · doi:10.1056/nejmra040832 · Cited by 667
Peyrot, M., Barnett, A. H., Meneghini, L. F., & Schumm‐Draeger, P. ‐. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03605.x · Cited by 655
Increased mortality of patients with diabetes reporting severe hypoglycemia
McCoy, R. G., Van Houten, H. K., Ziegenfuss, J. Y., Shah, N. D., Wermers, R. A., & Smith, S. A. (2012) · Diabetes Care · doi:10.2337/dc11-2054 · Cited by 539
Outpatient Insulin Therapy in Type 1 and Type 2 Diabetes Mellitus: Scientific Review
DeWitt, D. E., & Hirsch, I. B. (2003) · JAMA · doi:10.1001/jama.289.17.2254 · Cited by 502
Rosenstock, J., Davies, M., Home, P. D., Larsen, J., Koenen, C., & Schernthaner, G. (2008) · Diabetologia · doi:10.1007/s00125-007-0911-x · Cited by 447
Heller, S., Buse, J., Fisher, M., Garg, S., Marre, M., Merker, L., Renard, E., Russell-Jones, D., Philotheou, A., Francisco, A. M. O., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60204-9 · Cited by 402
Cited by
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A. R., Buse, J. B., Langer, R., & Gu, Z. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0508-y · Cited by 604
Self-citationInsulin analogues in type 1 diabetes mellitus: Getting better all the time
Mathieu, C., Gillard, P., & Benhalima, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.39 · Cited by 248
Commentary: Why Was Inhaled Insulin a Failure in the Market?
Oleck, J., Kassam, S., & Goldman, J. D. (2016) · Diabetes Spectrum · doi:10.2337/diaspect.29.3.180 · Cited by 84
Sun, X., Sheng, Y., Li, K., Sai, S., Feng, J., Li, Y., Zhang, J., Han, J., & Tian, B. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.10.047 · Cited by 79
Wang, J., Wang, Z., Yu, J., Zhang, Y., Zeng, Y., & Gu, Z. (2019) · Biomaterials Science · doi:10.1039/c9bm01283d · Cited by 21
Metadata
- Authors
- Chou, D. H.-C., Webber, M. J., Tang, B. C., Lin, A. B., Thapa, L. S., Deng, D., Truong, J. V., Cortinas, A. B., Langer, R., & Anderson, D. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-02-09
- Volume
- 112
- Issue
- 8
- Pages
- 2401-2406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973360240
- Cited by
- 234
- References
- 7
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. https://app.cochat.ai/papers/10.1073/pnas.1424684112
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- Chou, D. H.-C., Webber, M. J., Tang, B. C., Lin, A. B., Thapa, L. S., Deng, D., Truong, J. V., Cortinas, A. B., Langer, R., & Anderson, D. G. (2015). Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1424684112
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
