Cited by 667Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Insulin analogues

Hirsch, Irl B.·2005·New England Journal of Medicine

Abstract

In the 1990s, the value of glycemic control in the management of diabetes became incontrovertible. The interest in producing insulin formulations that are safer than previous formulations and that more closely duplicate the basal and mealtime components of endogenous insulin secretion has yielded insulin analogues with action profiles that afford more flexible treatment regimens and a lower risk of hypoglycemia. This article examines the use of these newer insulins in clinical practice.

Integrity signals

Registry

Crossref · 10.1056/nejmra040832

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65 of 65 references verified0 citation errors · 0 not checkable

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  • Improved glycemic control in the DCCT was associated with a 2-6 fold increase in severe hypoglycemia in intensive compared with conventionally treated subjects.

    “Specifically, improved glycemic control in the DCCT was associated with a 2–6 fold increase in severe hypoglycemia in intensive as compared to conventionally treated subjects101.”

    From Epidemiology of type 1 diabetes (2010) · cites this paper as [101]

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Authors
Hirsch, I. B.
Affiliations
University of Washington (US)
Corresponding author
Hirsch, Irl B.
Venue
New England Journal of Medicine
Published
2005-01-13
Volume
352
Issue
2
Pages
174-183
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4242554702
Cited by
667
References
62
Citations by year
2026: 13 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 23 · 2021: 16 · 2020: 26 · 2019: 19 · 2018: 31 · 2017: 29 · 2016: 36 · 2015: 36 · 2014: 27 · 2013: 39 · 2012: 46
FWCI
5.86
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin analogues, glycemic control, diabetes mellitus, hypoglycemia risk, insulin formulations
MeSH terms
Insulin Glargine, Child, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Drug Administration Schedule, Female, Humans, Hypoglycemic Agents, Insulin, Pregnancy, Blood Glucose Self-Monitoring, Insulin, Long-Acting, Insulin Aspart, Insulin Lispro

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