Cited by 181Neuroscience and Neuropharmacology ResearchCellular transport and secretionExtracellular vesicles in disease

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A large pool of releasable vesicles in a cortical glutamatergic synapse

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Hallermann, Stefan, Pawlu, Christian, Jonas, Peter, Heckmann, Manfred·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1432836100PMC PMC166423

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Abstract

To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse.

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Authors: Hallermann, S., Pawlu, C., Jonas, P., & Heckmann, M.
Affiliations: University of Freiburg (DE)
Physiologisches Institut, Universität Freiburg, D-79104 Freiburg, Germany
ORCID: Hallermann, Stefan
Heckmann, Manfred
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2003-06-18
Volume: 100
Issue: 15
Pages: 8975-8980
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1432836100
PMC: PMC166423
OpenAlex: W2133521893
Cited by: 181
References: 60
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 4
FWCI: 3.35
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: exocytosis, glutamatergic synapses, hippocampal mossy fibers, synaptic vesicles, capacitance measurement, presynaptic calcium influx, vesicle recycling, activity-dependent plasticity, equivalent circuit model
MeSH terms: Animals, Electrophysiology, Endocytosis, Exocytosis, Models, Neurological, Synaptic Transmission, Rats, Wistar, Mossy Fibers, Hippocampal, Secretory Vesicles, Electric Capacitance, Rats, In Vitro Techniques

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A large pool of releasable vesicles in a cortical glutamatergic synapse

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