Ultrastructural analysis of wild-type and RIM1α knockout active zones in a large cortical synapse
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Abstract
Rab3A-interacting molecule (RIM) is crucial for fast Ca 2+ -triggered synaptic vesicle (SV) release in presynaptic active zones (AZs). We investigated hippocampal giant mossy fiber bouton (MFB) AZ architecture in 3D using electron tomography of rapid cryo-immobilized acute brain slices in RIM1α −/− and wild-type mice. In RIM1α −/− , AZs are larger with increased synaptic cleft widths and a 3-fold reduced number of tightly docked SVs (0–2 nm). The distance of tightly docked SVs to the AZ center is increased from 110 to 195 nm, and the width of their electron-dense material between outer SV membrane and AZ membrane is reduced. Furthermore, the SV pool in RIM1α −/− is more heterogeneous. Thus, RIM1α, besides its role in tight SV docking, is crucial for synaptic architecture and vesicle pool organization in MFBs.
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The C2A domain of Munc13-1 interacts with the zinc-finger domain of RIM building a heterodimeric complex.
“In contrast, the C2A domain of Munc13-1 interacts with the zinc-finger domain of RIM building a heterodimeric complex [72,89–91].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [91]
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Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal
Vandael, D., & Jonas, P. (2024) · Science · doi:10.1126/science.adg6757 · Cited by 45 · see citing works
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
Tao, C.-L., Tian, C.-L., Liu, Y.-T., Lu, Z.-H., Qi, L., Li, X., Li, C., Shen, X., Gu, M., Huang, W.-L., et al. (2025) · Science · doi:10.1126/science.ads7954 · Cited by 29 · see citing works
Ehrenreich, H., Gassmann, M., Poustka, L., Burtscher, M., Hammermann, P., Sirén, A., Nave, K., & Miskowiak, K. W. (2023) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.15 · Cited by 19 · see citing works
Self-citationKim, O., Okamoto, Y., Kaufmann, W. A., Brose, N., Shigemoto, R., & Jonas, P. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002879 · Cited by 15 · see citing works
“In contrast, the C 2 A domain of Munc13-1 interacts with the zinc-finger domain of RIM building a heterodimeric complex [72,89–91].”
Short term plasticity at hippocampal mossy fiber synapses
Marneffe, C., Moreira-de-Sá, A., Lecomte, S., Erhardt, A., & Mulle, C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.09.044 · Cited by 13 · see citing works
Suzuki, C., Yamaguchi, J., Mitsui, S., Sanada, T., Trejo, J. A. O., Kakuta, S., Tanaka, K., Suda, Y., Hatano, T., Hattori, N., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167494 · Cited by 4 · see citing works
Lippmann, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136862 · Cited by 4 · see citing works
Visualizing Presynaptic Active Zones and Synaptic Vesicles
Heckmann, M., & Pauli, M. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.901341 · Cited by 3 · see citing works
Self-citationMrestani, A., Lichter, K., Sirén, A., Heckmann, M., Paul, M. M., & Pauli, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032128 · Cited by 1 · see citing works
Self-citationThe flexible synapse – How mossy fiber architecture adapts to changing needs
Bruentgens, F., Schmitz, D., & Orlando, M. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102882 · Cited by 1 · see citing works
Lichter, K. (2025) · Science · doi:10.1126/science.aec0091
Self-citationLin, L.-H., Li, W., Wu, Q.-Y., Li, S., Ma, X.-X., Xu, Y., Deng, S.-F., Zhang, B., & Liu, J. H. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01528-8
Morphofunctional Features of Hippocampal Mossy Fibers
Safiulina, V. F. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025060213
Ion‐ and Temperature‐Programmable Reconfiguration of Subcompartments in Synthetic Cells
Xu, Z., & Schwille, P. (2026) · ChemBioChem · doi:10.1002/cbic.202500928
- Authors
- Lichter, K., Paul, M. M., Pauli, M., Schoch, S., Kollmannsberger, P., Stigloher, C., Heckmann, M., & Sirén, A.-L.
- Affiliations
- University of Würzburg (DE)
- University Hospital Bonn (DE)
- Corresponding author
- Stigloher, Christian
- Heckmann, Manfred
- Sirén, Anna-Leena
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 40
- Issue
- 12
- Pages
- 111382
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4296478994
- Cited by
- 15
- References
- 87
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by-nc-nd)
- Funders
- Julius Maximilians University Würzburg
- Deutsche Forschungsgemeinschaft (218894163, CRC 166)
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
- European Molecular Biology Laboratory
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- active zone, synaptic vesicle docking, hippocampus, synaptic vesicle pools, synaptic cleft width, knockout mice
- MeSH terms
- Animals, Synaptic Transmission, Synapses, Synaptic Vesicles, Presynaptic Terminals, Mossy Fibers, Hippocampal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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