The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
Open accessAbstract
Significance: Despite the promise of personalized cancer medicine, most molecular therapies produce only modest and short-lived patient gains. In addition to drug resistance, it is also possible that tumors adaptively reprogram their signaling pathways to evade therapy-induced “stress” and, in the process, acquire more aggressive disease traits. We show here that small-molecule inhibitors of PI3K, a cancer node and important therapeutic target, induce transcriptional and signaling reprogramming in tumors. This involves the trafficking of energetically active mitochondria to subcellular sites of cell motility, where they provide a potent, “regional” energy source to support tumor cell invasion. Although this response may paradoxically increase the risk of metastasis during PI3K therapy, targeting mitochondrial reprogramming is feasible, and could provide a novel therapeutic strategy.
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Cites
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ER-mitochondria interactions: Both strength and weakness within cancer cells
Doghman-Bouguerra, M., & Lalli, E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.01.009 · Cited by 94
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Metadata
- Authors
- Caino, M. C., Ghosh, J. C., Chae, Y. C., Vaira, V., Rivadeneira, D. B., Faversani, A., Rampini, P., Kossenkov, A. V., Aird, K. M., Zhang, R., Webster, M. R., Weeraratna, A. T., Bosari, S., Languino, L. R., & Altieri, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-29
- Volume
- 112
- Issue
- 28
- Pages
- 8638-8643
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1958855774
- Cited by
- 197
- References
- 9
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Caino, M. C., Ghosh, J. C., Chae, Y. C., Vaira, V., Rivadeneira, D. B., Faversani, A., Rampini, P., Kossenkov, A. V., Aird, K. M., Zhang, R., Webster, M. R., Weeraratna, A. T., Bosari, S., Languino, L. R., & Altieri, D. C. (2015). PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1500722112
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