The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health
Open accessAbstract
Significance: Klebsiella pneumoniae is rapidly becoming untreatable using last-line antibiotics. It is especially problematic in hospitals, where it causes a range of acute infections. To approach controlling such a bacterium, we first must define what it is and how it varies genetically. Here we have determined the DNA sequence of K . pneumoniae isolates from around the world and present a detailed analysis of these data. We show that there is a wide spectrum of diversity, including variation within shared sequences and gain and loss of whole genes. Using this detailed blueprint, we show that there is an unrecognized association between the possession of specific gene profiles associated with virulence and antibiotic resistance and the differing disease outcomes seen for K . pneumoniae .
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Citations
Cites
Inference of Population Structure using Dense Haplotype Data
Lawson, D. J., Hellenthal, G., Myers, S., & Falush, D. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002453 · Cited by 1,188
Snitkin, E. S., Zelazny, A. M., Thomas, P. J., Stock, F., Program, N. C. S., Henderson, D. K., Palmore, T. N., & Segre, J. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004129 · Cited by 863
Jones, R. N. (2010) · Clinical Infectious Diseases · doi:10.1086/653053 · Cited by 716
Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
Chen, Y.-T., Chang, H.-Y., Lai, Y.-C., Pan, C.-C., Tsai, S.-F., & Peng, H.-L. (2004) · Gene · doi:10.1016/j.gene.2004.05.008 · Cited by 351 · cited 1×
“pneumoniae virulence plasmids pLVPK and pK2044 (43, 50) (SI Appendix, Table S1).”
BackgroundDiverging roles of bacterial siderophores during infection
Holden, V. I., & Bachman, M. A. (2015) · Metallomics · doi:10.1039/c4mt00333k · Cited by 274 · cited 2×
“pneumoniae and other Enterobacteriaceae with hosts, including modulating immune responses via the host protein lipocalin 2, binding noniron metal ions, and protecting against reactive oxygen species (51).”
Background
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Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation
Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957
Russo, T. A., Olson, R., Fang, C.-T., Stoesser, N., Miller, M., MacDonald, U., Hutson, A., Barker, J. H., La Hoz, R. M., Johnson, J. R., et al. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.00776-18 · Cited by 783
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
David, S., Reuter, S., Harris, S. R., Glasner, C., Feltwell, T., Argimon, S., Abudahab, K., Goater, R., Giani, T., Errico, G., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0492-8 · Cited by 773
Klebsiella pneumoniae: an increasing threat to public health
Effah, C. Y., Sun, T., Liu, S., & Wu, Y. (2020) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-019-0343-8 · Cited by 558
(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., De Cesare, A., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 445
Metadata
- Authors
- Holt, K. E., Wertheim, H., Zadoks, R. N., Baker, S., Whitehouse, C. A., Dance, D., Jenney, A., Connor, T. R., Hsu, L. Y., Severin, J., Brisse, S., Cao, H., Wilksch, J., Gorrie, C., Schultz, M. B., Edwards, D. J., Nguyen, K. V., Nguyen, T. V., Dao, T. T., Mensink, M., Minh, V. L., Nhu, N. T. K., Schultsz, C., Kuntaman, K., Newton, P. N., Moore, C. E., Strugnell, R. A., & Thomson, N. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-22
- Volume
- 112
- Issue
- 27
- Pages
- E3574-81
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1895017250
- Cited by
- 1,236
- References
- 5
- FWCI
- 30.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health. https://app.cochat.ai/papers/10.1073/pnas.1501049112
- The paper
- Holt, K. E., Wertheim, H., Zadoks, R. N., Baker, S., Whitehouse, C. A., Dance, D., Jenney, A., Connor, T. R., Hsu, L. Y., Severin, J., Brisse, S., Cao, H., Wilksch, J., Gorrie, C., Schultz, M. B., Edwards, D. J., Nguyen, K. V., Nguyen, T. V., Dao, T. T., . . . Thomson, N. R. (2015). Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1501049112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
