Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43

tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence

Lowe, T. M., & Eddy, S. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.955 · Cited by 11,120 · see citing works

Base-Calling of Automated Sequencer Traces Using Phred. I. Accuracy AssessmentPreprint

Ewing, B., Hillier, L., Wendl, M. C., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.175 · Cited by 6,993 · see citing works

Consed: a graphical tool for sequence finishing.Preprint

Gordon, D., Abajian, C., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.195 · Cited by 3,706 · see citing works

Improved microbial gene identification with GLIMMER

Delcher, A. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4636 · Cited by 2,493 · see citing works

Major trends in the microbial etiology of nosocomial infection

Schaberg, D. R., Culver, D. H., & Gaynes, R. P. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90346-y · Cited by 1,119 · see citing works

Molecular basis for resistance to silver cations in Salmonella

Gupta, A. K., Matsui, K., Lo, J., & Silver, S. D. (1999) · Nature Medicine · doi:10.1038/5545 · Cited by 474 · see citing works

Cloning and Functional Analysis of the pbr Lead Resistance Determinant of Ralstonia metallidurans CH34

Borremans, B., Hobman, J. L., Provoost, A., Brown, N., & van der Lelie, D. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.19.5651-5658.2001 · Cited by 282 · see citing works

ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12

Köster, W. L. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01200-1 · Cited by 277 · see citing works

Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin

Nassif, X., & Sansonetti, P. J. (1986) · Infection and Immunity · doi:10.1128/iai.54.3.603-608.1986 · Cited by 276 · see citing works

Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor

Nassif, X., Fournier, J. M., Arondel, J., & Sansonetti, P. J. (1989) · Infection and Immunity · doi:10.1128/iai.57.2.546-552.1989 · Cited by 276 · see citing works

Molecular genetics and transport analysis of the copper‐resistance determinant (pco) from Escherichia coli plasmid pRJ1004

Brown, N. L., Barrett, S. R., Camakaris, J., Lee, B. T. O., & Rouch, D. A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_17061153.x · Cited by 248 · see citing works

Control of plasmid DNA replication by iterons: no longer paradoxical

Chattoraj, D. K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01986.x · Cited by 217 · see citing works

Pb(II)-translocating P-type ATPases

Rensing, C., Sun, Y., Mitra, B., & Rosen, B. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32614 · Cited by 193 · see citing works

Regulation of the FecI-type ECF sigma factor by transmembrane signalling

Braun, V., Mahren, S., & Ogierman, M. A. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00022-5 · Cited by 162 · see citing works

RmpA2, an Activator of Capsule Biosynthesis inKlebsiella pneumoniaeCG43, Regulates K2cpsGene Expression at the Transcriptional Level

Lai, Y., Peng, H., & Chang, H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.3.788-800.2003 · Cited by 159 · see citing works

Genomic Variability of O Islands Encoding Tellurite Resistance in Enterohemorrhagic Escherichia coli O157:H7 Isolates

Taylor, D. E., Rooker, M. M., Keelan, M., Ng, L.-K., Martín, I. F., Perna, N. T., Burland, N. T. V., & Blattner, F. R. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.17.4690-4698.2002 · Cited by 139 · see citing works

The selC‐associated SHI‐2 pathogenicity island of Shigella flexneri

Moss, J. E., Cardozo, T. J., Zychlinsky, A., & Groisman, E. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01449.x · Cited by 137 · see citing works

The role of K antigens as virulence factors in Klebsiella

Simoons‐Smit, A. M., Vught, A. M. J. J. V.-V., & MacLaren, D. M. (1986) · Journal of Medical Microbiology · doi:10.1099/00222615-21-2-133 · Cited by 134 · see citing works

Recognition of the P1 plasmid centromere analog involves binding of the ParB protein and is modified by a specific host factor.

Davis, M. A., & Austin, S. J. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03021.x · Cited by 116 · see citing works

Regulation of citrate‐dependent iron transport of Escherichia coli: FecR is required for transcription activation by Feel

Ochs, M. M., Veitinger, S., Kim, I., Weiz, D., Angerer, A., & Braun, V. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02226.x · Cited by 98 · see citing works

Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ

Wacharotayankun, R., Arakawa, Y., Ohta, M., Tanaka, K., Akashi, T., Mori, M., & Kato, N. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3164-3174.1993 · Cited by 97 · see citing works

G-language Genome Analysis Environment: a workbench for nucleotide sequence data mining

Arakawa, K., Mori, K., Ikeda, K., Matsuzaki, T., Kobayashi, Y., & Tomita, M. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.305 · Cited by 93 · see citing works

A Salmonella dublin virulence plasmid locus that affects bacterial growth under nutrient‐limited conditions

Pullinger, G. D., & Lax, A. J. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb00888.x · Cited by 89 · see citing works

Characterization of an iroBCDEN Gene Cluster on a Transmissible Plasmid of Uropathogenic Escherichia coli : Evidence for Horizontal Transfer of a Chromosomal Virulence Factor

Sorsa, L. J., Dufke, S., Heesemann, J., & Schubert, S. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3285-3293.2003 · Cited by 85 · see citing works

Identification of Genes Induced In Vivo during Klebsiella pneumoniae CG43 Infection

Lai, Y., Peng, H., & Chang, H. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.7140-7145.2001 · Cited by 83 · see citing works

Transfer RNAs and pathogenicity islands

Hou, Y. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01428-0 · Cited by 75 · see citing works

The F plasmid centromere, sopC , is required for full repression of the sopAB operon 1 1Edited by I. B. Holland

Yates, P. L., Lane, D., & Biek, D. P. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2909 · Cited by 55 · see citing works

Escherichia coli ColV plasmid pRK100: genetic organization, stability and conjugal transfer

Avguštin, J. A., OstroveršKnik, A., StarčKičK, M., Kuhar, I., Grabnar, M., & Žgur‐Bertok, D. (1998) · Microbiology · doi:10.1099/00221287-144-2-343 · Cited by 27 · see citing works

Comparison of disc diffusion & E test methods with agar dilution for antimicrobial susceptibility testing of Haemophilus influenzae.

Manoharan, A., Pai, R. B., Shankar, V., Thomas, K., & Lalitha, M. K. (2003) · PubMed · Cited by 26 · see citing works

Molecular epidemiology of Klebsiella pneumoniae.

Peng, H., Wang, P. Y., Wu, J.-W., Chiu, C., & Chang, H. Y. (1991) · PubMed · Cited by 18 · see citing works

Klebsiella pneumoniae: Going on the Offense with a Strong Defense

Paczosa, M., & Mecsas, J. (2016) · Microbiology and Molecular Reviews · doi:10.1128/mmbr.00078-15 · Cited by 1,769 · see citing works

Hypervirulent Klebsiella pneumoniae

Russo, T. A., & Marr, C. M. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-19 · Cited by 1,332 · see citing works

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Holt, K. E., Wertheim, H. F. L., Zadoks, R. N., Baker, S. G., Whitehouse, C. A., Dance, D. A. B., Jenney, A., Connor, T. R., Hsu, L. Y., Severin, J. A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501049112 · Cited by 1,276 · see citing works

Hypervirulent (hypermucoviscous) Klebsiella pneumoniae

Shon, A. S. Y., Bajwa, R. P. S., & Russo, T. A. (2013) · Virulence · doi:10.4161/viru.22718 · Cited by 1,175 · see citing works

Population genomics of Klebsiella pneumoniae

Wyres, K. L., Lam, M. M. C., & Holt, K. E. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0315-1 · Cited by 1,175 · see citing works

Efflux-mediated antimicrobial resistance

Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082 · see citing works

A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study

Gu, D., Dong, N., Zheng, Z., Lin, D., Huang, M., Wang, L., Chan, E. W., Shu, L., Yu, J., Zhang, R., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30489-9 · Cited by 1,059 · see citing works

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

Choby, J. E., Howard-Anderson, J. R., & Weiss, D. S. (2019) · Journal of Internal Medicine · doi:10.1111/joim.13007 · Cited by 719 · see citing works

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

White, C., Lee, J., Kambe, T., Fritsche, K., & Petris, M. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070201 · Cited by 524 · see citing works

Genomic Definition of Hypervirulent and Multidrug-Resistant <i>Klebsiella pneumoniae</i> Clonal Groups

Bialek-Davenet, S., Criscuolo, A., Ailloud, F., Passet, V., Jones, L., Delannoy-Vieillard, A.-S., Garin, B., Le Hello, S., Arlet, G., Nicolas-Chanoine, M.-H., et al. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2011.140206 · Cited by 481 · see citing works

Bacterial antimicrobial metal ion resistance

Hobman, J. L., & Crossman, L. C. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.023036-0 · Cited by 401 · see citing works

Genome Sequencing and Comparative Analysis of Klebsiella pneumoniae NTUH-K2044, a Strain Causing Liver Abscess and Meningitis

Wu, K.-M., Li, L.-H., Yan, J.-J., Tsao, N., Liao, T.-L., Tsai, H.-C., Fung, C., Chen, H.-J., Liu, Y.-M., Wang, J.-T., et al. (2009) · Journal of Bacteriology · doi:10.1128/jb.00315-09 · Cited by 381 · see citing works

Mapping the Evolution of Hypervirulent Klebsiella pneumoniae

Struve, C., Roe, C. C., Stegger, M., Stahlhut, S. G., Hansen, D. S., Engelthaler, D. M., Andersen, P. S., Driebe, E. M., Keim, P., & Krogfelt, K. A. (2015) · mBio · doi:10.1128/mbio.00630-15 · Cited by 367 · see citing works

Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?

Catalán-Nájera, J. C., Garza–Ramos, U., & Barrios-Camacho, H. (2017) · Virulence · doi:10.1080/21505594.2017.1317412 · Cited by 364 · see citing works

Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

Wyres, K. L., Nguyen, T. N. T., Lam, M. M. C., Judd, L. M., Châu, N. V. V., Dance, D. A. B., Ip, M., Karkey, A., Ling, C. L., Miliya, T., et al. (2020) · Genome Medicine · doi:10.1186/s13073-019-0706-y · Cited by 324 · see citing works

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

Putze, J., Hennequin, C., Nougayrède, J., Zhang, W., Homburg, S., Karch, H., Bringer, M.-A., Fayolle, C., Carniel, É., Rabsch, W., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00522-09 · Cited by 319 · see citing works

Virulence Factors in Hypervirulent Klebsiella pneumoniae

Zhu, J., Wang, T., Chen, L., & Du, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.642484 · Cited by 324 · see citing works

How pathogenic bacteria evade mammalian sabotage in the battle for iron

Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2006) · Nature Chemical Biology · doi:10.1038/nchembio771 · Cited by 321 · see citing works

Klebsiella species: Taxonomy, hypervirulence and multidrug resistance

Dong, N., Yang, X., Chan, E. W., Zhang, R., & Chen, S. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103998 · Cited by 316 · see citing works

Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae <i>Ex Vivo</i> and <i>In Vivo</i>

Russo, T. A., Olson, R., MacDonald, U., Beanan, J., & Davidson, B. A. (2015) · Infection and Immunity · doi:10.1128/iai.00430-15 · Cited by 305 · see citing works

Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae

Russo, T. A., Olson, R., MacDonald, U., Metzger, D., Maltese, L. M., Drake, E. J., & Gulick, A. M. (2014) · Infection and Immunity · doi:10.1128/iai.01667-13 · Cited by 305 · see citing works

Capsular Serotype K1 or K2, Rather than magA and rmpA , Is a Major Virulence Determinant for Klebsiella pneumoniae Liver Abscess in Singapore and Taiwan

Yeh, K., Kurup, A., Siu, L.-K. K., Koh, Y. L., Fung, C., Lin, J., Chen, T.-L., Chang, F., & Koh, T. H. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01150-06 · Cited by 296 · see citing works

Complete Genome Sequence of the N2-Fixing Broad Host Range Endophyte Klebsiella pneumoniae 342 and Virulence Predictions Verified in Mice

Fouts, D. E., Tyler, H. L., DeBoy, R. T., Daugherty, S. C., Ren, Q., Badger, J. H., Durkin, A. S., Huot, H., Shrivastava, S., Kothari, S. P., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000141 · Cited by 293 · see citing works

Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae

Yang, X., Dong, N., Chan, E. W., Zhang, R., & Chen, S. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.04.012 · Cited by 290 · see citing works

A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae

Lan, P., Jiang, Y., Zhou, J., & Yu, Y. (2021) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2021.02.020 · Cited by 282 · see citing works

Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae

Lam, M. M. C., Wyres, K. L., Judd, L. M., Wick, R. R., Jenney, A. W. J., Brisse, S., & Holt, K. E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0587-5 · Cited by 274 · see citing works

RmpA Regulation of Capsular Polysaccharide Biosynthesis in Klebsiella pneumoniae CG43

Cheng, H., Chen, Y., Wu, C.-C., Chang, H. Y., Lai, Y., & Peng, H. (2010) · Journal of Bacteriology · doi:10.1128/jb.00031-10 · Cited by 270 · see citing works

Klebsiella variicola : an emerging pathogen in humans

Rodríguez-Medina, N., Barrios-Camacho, H., Dúran-Bedolla, J., & Garza–Ramos, U. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1634981 · Cited by 248 · see citing works

Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant

Pomakova, D. K., Hsiao, C.-B., Beanan, J. M., Olson, R., MacDonald, U., Keynan, Y., & Russo, T. A. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1396-6 · Cited by 244 · see citing works

Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumoniae strains isolated from different clinical specimens

Fertas-Aissani, R. E., Messai, Y., Alouache, S., & Bakour, R. (2012) · Pathologie Biologie · doi:10.1016/j.patbio.2012.10.004 · Cited by 243 · see citing works

Serum‐Induced Iron‐Acquisition Systems and TonB Contribute to Virulence inKlebsiella pneumoniaeCausing Primary Pyogenic Liver Abscess

Hsieh, P., Lin, T., Lee, C., Tsai, S., & Wang, J.-T. (2008) · The Journal of Infectious Diseases · doi:10.1086/588383 · Cited by 240 · see citing works

Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China

Zhang, R., Lin, D., Chan, E. W., Gu, D., Chen, G., & Chen, S. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02173-15 · Cited by 229 · see citing works

Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: the Klebsiella pneumoniae Paradigm

Ramirez, M. S., Traglia, G. M., Lin, D. L., Tran, T., & Tolmasky, M. E. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.plas-0016-2013 · Cited by 212 · see citing works

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

Walker, K. A., Miner, T. A., Palacios, M., Trzilova, D., Frederick, D. R., Broberg, C. A., Sepúlveda, V. E., Quinn, J. D., & Miller, V. L. (2019) · mBio · doi:10.1128/mbio.00089-19 · Cited by 200 · see citing works

Lead resistance in micro-organisms

Jarosławiecka, A. K., & Piotrowska‐Seget, Z. (2013) · Microbiology · doi:10.1099/mic.0.070284-0 · Cited by 200 · see citing works

Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin

Bachman, M. A., Miller, V. L., & Weiser, J. N. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000622 · Cited by 186 · see citing works

Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

Nash, J. J., Villegas, A., Kropinski, A. M., Aguilar‐Valenzuela, R., Konczy, P., Mascarenhas, M., Ziebell, K. A., Torres, A. G., Karmali, M. A., & Coombes, B. K. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-667 · Cited by 194 · see citing works

“Superbugs” with hypervirulence and carbapenem resistance in Klebsiella pneumoniae: The rise of such emerging nosocomial pathogens in China

Pu, D., Zhao, J., Chang, K., Zhuo, X., & Cao, B. (2023) · Science Bulletin · doi:10.1016/j.scib.2023.09.040 · Cited by 194 · see citing works

Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China

Yang, X., Sun, Q., Li, J., Yu, J., Li, Y., Lin, J., Chen, K., Chan, E. W., Zhang, R., & Chen, S. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2049458 · Cited by 186 · see citing works

Emerging Severe and Fatal Infections Due to Klebsiella pneumoniae in Two University Hospitals in France

Decré, D., Verdet, C., Emirian, A., Gourrierec, T. L., Petit, J., Offenstadt, G., Maury, É., Brisse, S., & Arlet, G. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00676-11 · Cited by 182 · see citing works

The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae

Walker, K. A., & Miller, V. L. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.01.006 · Cited by 181 · see citing works

Genomic Heterogeneity inKlebsiella pneumoniaeStrains Is Associated with Primary Pyogenic Liver Abscess and Metastatic Infection

Ma, L., Fang, C., Lee, C., Shun, C., & Wang, J. (2005) · The Journal of Infectious Diseases · doi:10.1086/430619 · Cited by 167 · see citing works

Hypervirulent K. Pneumoniae Secretes More and More Active Iron-Acquisition Molecules than “Classical” K. Pneumoniae Thereby Enhancing its Virulence

Russo, T. A., Shon, A. S., Beanan, J. M., Olson, R., MacDonald, U., Pomakov, A. O., & Visitacion, M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026734 · Cited by 153 · see citing works

A conjugative plasmid that augments virulence in Klebsiella pneumoniae

Yang, X., Chan, E. W., Zhang, R., & Chen, S. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0566-7 · Cited by 152 · see citing works

The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort

Dorman, M. J., Feltwell, T., Goulding, D., Parkhill, J., & Short, F. L. (2018) · mBio · doi:10.1128/mbio.01863-18 · Cited by 151 · see citing works

Correlation between antimicrobial resistance and virulence in Klebsiella pneumoniae

Hennequin, C., & Robin, F. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2559-7 · Cited by 149 · see citing works

Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance

Russo, T. A., Alvarado, C. L., Davies, C. J., Drayer, Z. J., MacDonald, U., Hutson, A. D., Luo, T. L., Martin, M. J., Corey, B. W., Moser, K. A., et al. (2024) · mBio · doi:10.1128/mbio.02867-23 · Cited by 149 · see citing works

The ins and outs of siderophore mediated iron uptake by extra-intestinal pathogenic Escherichia coli

Garénaux, A., Caza, M., & Dozois, C. M. (2011) · Veterinary Microbiology · doi:10.1016/j.vetmic.2011.05.023 · Cited by 141 · see citing works

The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae

Walker, K. A., Treat, L. P., Sepúlveda, V. E., & Miller, V. L. (2020) · mBio · doi:10.1128/mbio.01750-20 · Cited by 141 · see citing works

Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae

Xu, Y., Zhang, J., Wang, M., Liu, M., Liu, G., Qu, H., Liu, J., Deng, Z., Sun, J., Ou, H., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00936-5 · Cited by 141 · see citing works

Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones

Arcari, G., & Carattoli, A. (2022) · Pathogens and Global Health · doi:10.1080/20477724.2022.2121362 · Cited by 138 · see citing works

Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae

Gomez‐Simmonds, A., & Uhlemann, A. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw378 · Cited by 130 · see citing works

Transcriptomic and proteomic analyses of the pMOL30-encoded copper resistance in Cupriavidus metallidurans strain CH34

Monchy, S., Benotmane, M. A., Wattiez, R., van Aelst, S., Auquier, V., Borremans, B., Mergeay, M., Taghavi, S., van der Lelie, D., & Vallaeys, T. (2006) · Microbiology · doi:10.1099/mic.0.28593-0 · Cited by 130 · see citing works

Characterization of Integrative and Conjugative Element ICEKp1-Associated Genomic Heterogeneity in aKlebsiella pneumoniaeStrain Isolated from a Primary Liver Abscess

Lin, T., Lee, C., Hsieh, P., Tsai, S., & Wang, J. (2007) · Journal of Bacteriology · doi:10.1128/jb.01219-07 · Cited by 128 · see citing works

The 120 592 bp IncF plasmid pRSB107 isolated from a sewage-treatment plant encodes nine different antibiotic-resistance determinants, two iron-acquisition systems and other putative virulence-associated functions

Szczepanowski, R., Braun, S. B., Riedel, V., Schneiker, S., Krahn, I., Pühler, A., & Schlüter, A. (2005) · Microbiology · doi:10.1099/mic.0.27773-0 · Cited by 127 · see citing works

Specific Roles of the iroBCDEN Genes in Virulence of an Avian Pathogenic Escherichia coli O78 Strain and in Production of Salmochelins

Caza, M., Lepine, F. L., Milot, S. M., & Dozois, C. M. (2008) · Infection and Immunity · doi:10.1128/iai.00455-08 · Cited by 126 · see citing works

Clinical and Molecular Characteristics of Klebsiella pneumoniae Isolates Causing Bloodstream Infections in Japan: Occurrence of Hypervirulent Infections in Health Care

Harada, S., Aoki, K., Yamamoto, S., Ishii, Y., Sekiya, N., Kurai, H., Furukawa, K., Doi, A., Tochitani, K., Kubo, K., et al. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01206-19 · Cited by 126 · see citing works

Metabolite Transporter PEG344 Is Required for Full Virulence of Hypervirulent Klebsiella pneumoniae Strain hvKP1 after Pulmonary but Not Subcutaneous Challenge

Bulger, J. L., MacDonald, U., Olson, R., Beanan, J. M., & Russo, T. A. (2017) · Infection and Immunity · doi:10.1128/iai.00093-17 · Cited by 125 · see citing works

Virulence genes in isolates of Klebsiella pneumoniae from the UK during 2016, including among carbapenemase gene-positive hypervirulent K1-ST23 and ‘non-hypervirulent’ types ST147, ST15 and ST383

Turton, J. F., Payne, Z., Coward, A., Hopkins, K. L., Turton, J. A., Doumith, M., & Woodford, N. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000653 · Cited by 124 · see citing works

Correlation between Klebsiella pneumoniae carrying pLVPK-derived loci and abscess formation

Tang, H., Chiang, M., Liou, W.-J., Chen, Y.-T., Peng, H.-L., Chiou, C., Liu, K. S., Lu, M., Tung, K., & Lai, Y. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-0915-1 · Cited by 118 · see citing works

Klebsiella pneumoniae : Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium

Hu, Y., Anes, J., Devineau, S., & Fanning, S. (2020) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2020.2847 · Cited by 113 · see citing works

Novel microchip for in situ TEM imaging of living organisms and bio-reactions in aqueous conditions

Liu, K.-L., Wu, C.-C., Huang, Y.-J., Peng, H., Chang, H., Chang, P., Hsu, L., & Yew, T. (2008) · Lab on a Chip · doi:10.1039/b804986f · Cited by 112 · see citing works

Whole genome analysis of hypervirulent Klebsiella pneumoniae isolates from community and hospital acquired bloodstream infection

Shankar, C., Veeraraghavan, B., Nabarro, L., Ravi, R., Ragupathi, N. K. D., & Rupali, P. (2018) · BMC Microbiology · doi:10.1186/s12866-017-1148-6 · Cited by 111 · see citing works

Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains

Yu, F., Lv, J., Niu, S., Du, H., Tang, Y., Pitout, J. D. D., Bonomo, R. A., Kreiswirth, B. N., & Chen, L. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.00731-18 · Cited by 111 · see citing works

Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae

Han, Y., Wen, X., Zhao, W., Cao, X., Wen, J.-X., Wang, J., Hu, Z.-D., & Zheng, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1003783 · Cited by 111 · see citing works

Clinical and Genomic Analysis of Liver Abscess-Causing Klebsiella pneumoniae Identifies New Liver Abscess-Associated Virulence Genes

Ye, M., Tu, J., Jiang, J., Bi, Y., You, W., Zhang, Y., Ren, J., Zhu, T., Cao, Z., Yu, Z., et al. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00165 · Cited by 110 · see citing works

Hypervirulent Klebsiella pneumoniae induced ventilator-associated pneumonia in mechanically ventilated patients in China

Yan, Q., Zhou, M., Zou, M., & Liu, W.-E. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2551-2 · Cited by 107 · see citing works

Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae

Xie, M., Yang, X., Xu, Q., Ye, L., Chen, K., Zheng, Z., Dong, N., Sun, Q., Shu, L., Gu, D., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02148-4 · Cited by 107 · see citing works

Complete Nucleotide Sequence of pK245, a 98-Kilobase Plasmid Conferring Quinolone Resistance and Extended-Spectrum-β-Lactamase Activity in a Clinical Klebsiella pneumoniae Isolate

Chen, Y.-T., Shu, H., Li, L.-H., Liao, T.-L., Wu, K.-M., Shiau, Y., Yan, J.-J., Su, I., Tsai, S., & Lauderdale, T.-L. Y. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00456-06 · Cited by 107 · see citing works

Evolution of a heavy metal homeostasis/resistance island reflects increasing copper stress in Enterobacteria

Staehlin, B. M., Gibbons, J. G., Rokas, A., O’Halloran, T. V., & Slot, J. C. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw031 · Cited by 106 · see citing works

Molecular epidemiology and virulence factors of pyogenic liver abscess causing Klebsiella pneumoniae in China

Luo, Y., Wang, Y., Ye, L., & Yang, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12664 · Cited by 105 · see citing works

Neonatal Sepsis: The Impact of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae

Mukherjee, S., Mitra, S., Dutta, S., & Basu, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.634349 · Cited by 104 · see citing works

Hypermucoviscosity associated with Klebsiella pneumoniae-mediated invasive syndrome: a prospective cross-sectional study in Taiwan

Lee, C., Liu, J.-W., Su, L., Chien, C., Li, C.-C., & Yang, K.-D. (2010) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2010.01.007 · Cited by 102 · see citing works

The making of hypervirulent Klebsiella pneumoniae

Dai, P., & Hu, D. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24743 · Cited by 102 · see citing works

DNA Sequence and Comparative Genomics of pAPEC-O2-R, an Avian Pathogenic Escherichia coli Transmissible R Plasmid

Johnson, T. J., Siek, K. E., Johnson, S. J., & Nolan, L. K. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.11.4681-4688.2005 · Cited by 100 · see citing works

High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China

Xu, M., Fu, Y., Fang, Y., Xu, H., Kong, H., Liu, Y., Chen, Y., & Li, L. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s191892 · Cited by 98 · see citing works

Genetic Requirements for Klebsiella pneumoniae -Induced Liver Abscess in an Oral Infection Model

Tu, Y.-C., Lu, M., Chiang, M., Huang, S.-P., Peng, H., Chang, H., Jan, M., & Lai, Y. (2009) · Infection and Immunity · doi:10.1128/iai.01523-08 · Cited by 95 · see citing works

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Kochan, T. J., Nozick, S., Medernach, R. L., Cheung, B. H., Gatesy, S. W. M., Lebrun-Corbin, M., Mitra, S. D., Khalatyan, N., Krapp, F., Qi, C., et al. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07558-1 · Cited by 91 · see citing works

Whole genome assembly and functional portrait of hypervirulent extensively drug-resistant NDM-1 and KPC-2 co-producing Klebsiella pneumoniae of capsular serotype K2 and ST86

Liu, Y., Long, D., Xiang, T., Du, F.-L., Wei, D. D., Wan, L., Deng, Q., Cao, X., & Zhang, W. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz023 · Cited by 94 · see citing works

Genetic diversity and composition of a plasmid metagenome from a wastewater treatment plant

Schlüter, A., Krause, L., Szczepanowski, R., Goesmann, A., & Pühler, A. (2008) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2008.03.017 · Cited by 92 · see citing works

Fur regulation of the capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43

Lin, C.-T., Wu, C.-C., Chen, Y.-S., Lai, Y.-C., Chi, C., Lin, J.-C., Chen, Y., & Peng, H.-L. (2011) · Microbiology · doi:10.1099/mic.0.044065-0 · Cited by 86 · see citing works

Metabolic diversity of the emerging pathogenic lineages of Klebsiella pneumoniae

Blin, C., Passet, V., Touchon, M., Rocha, E. P. C., & Brisse, S. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13689 · Cited by 89 · see citing works

Characterization of Putative Virulence Genes on the Related RepFIB Plasmids Harbored by Cronobacter spp

Franco, A. A., Hu, L., Grim, C. J., Gopinath, G., Sathyamoorthy, V., Jarvis, K. G., Lee, C., Sadowski, J., Kim, J., Kothary, M. H., et al. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.03023-10 · Cited by 87 · see citing works

Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains

Dong, N., Yang, X., Zhang, R., Chan, E. W., & Chen, S. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0146-6 · Cited by 87 · see citing works

Carriage of blaKPC-2 by a virulence plasmid in hypervirulent Klebsiella pneumoniae

Dong, N., Lin, D., Zhang, R., Chan, E. W., & Chen, S. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky358 · Cited by 84 · see citing works

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

Shu, L., Dong, N., Lu, J., Zheng, Z., Hu, J., Zeng, W., Sun, Q., Chan, E. W., Zhou, H., Hu, F., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02246-18 · Cited by 82 · see citing works

Resistance to Metals Used in Agricultural Production

Rensing, C., Moodley, A., Cavaco, L. M., & McDevitt, S. F. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.arba-0025-2017 · Cited by 80 · see citing works

Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India

Shankar, C., Vasudevan, K., Jacob, J. J., Baker, S. G., Isaac, B. J., Neeravi, A., Sethuvel, D. P. M., George, B., & Veeraraghavan, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.875116 · Cited by 79 · see citing works

Virulence analysis and antibiotic resistance of Klebsiella pneumoniae isolates from hospitalised patients in Poland

Kot, B., Piechota, M., Szweda, P., Mitrus, J. M., Wicha, J., Grużewska, A., & Witeska, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-31086-w · Cited by 78 · see citing works

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore

Chen, Y., Marimuthu, K., Teo, J. W. P., Venkatachalam, I., Cherng, B. P. Z., Wang, L. D., Prakki, S. R. S., Wei-zhen, X., Tan, Y. H., Nguyen, L. C., et al. (2020) · Emerging infectious diseases · doi:10.3201/eid2603.191230 · Cited by 77 · see citing works

Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China

Yang, Y., Yang, Y., Chen, G., Lin, M., Chen, Y., He, R., Galvão, K. N., Ahmed, M. A. E.-G. E.-S., Roberts, A. P., Wu, Y., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1906163 · Cited by 76 · see citing works

Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens

Gulick, A. M. (2017) · Natural Product Reports · doi:10.1039/c7np00029d · Cited by 73 · see citing works

Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence

Shankar, C., Basu, S., Lal, B., Shanmugam, S., Vasudevan, K., Mathur, P., Ramaiah, S., Anbarasu, A., & Veeraraghavan, B. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.709681 · Cited by 73 · see citing works

Carbapenem-resistant Klebsiella pneumoniae : the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge

Pilato, V. D., Pollini, S., Miriagou, V., Rossolini, G. M., & D’Andrea, M. M. (2024) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2024.2305854 · Cited by 74 · see citing works

Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae : An epidemiological, genomic and functional study

Li, P., Liang, Q., Liu, W., Zheng, B., Liu, L., Wang, W., Xu, Z., Huang, M., & Feng, Y. (2020) · Virulence · doi:10.1080/21505594.2020.1867468 · Cited by 73 · see citing works

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

He, J., Shi, Q., Chen, Z., Zhang, W., Lan, P., Xu, Q., Hu, H., Chen, Q., Jianzhong, F., Jiang, Y., et al. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100891 · Cited by 73 · see citing works

Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length

Ovchinnikova, O. G., Treat, L. P., Teelucksingh, T., Clarke, B. R., Miner, T. A., Whitfield, C., Walker, K. A., & Miller, V. L. (2023) · mBio · doi:10.1128/mbio.00800-23 · Cited by 73 · see citing works

From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models

Joseph, L., Merciecca, T., Forestier, C., Balestrino, D., & Miquel, S. (2021) · Microorganisms · doi:10.3390/microorganisms9061282 · Cited by 72 · see citing works

Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae

Liu, L., Lou, N., Liang, Q., Xiao, W., Teng, G., Ma, J., Zhang, H., Huang, M., & Feng, Y. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.10.038 · Cited by 72 · see citing works

Etiology and Cytokine Expression in Patients Requiring Mechanical Ventilation Due to Severe Community-acquired Pneumonia

Wu, C., Chan, M.-C., Chang, C.-C., Lee, Y.-L., Chin, C.-S., Chang, K.-M., & Hsu, J. (2006) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60108-x · Cited by 71 · see citing works

A Siderophore-Encoding Plasmid Encodes High-Level Virulence in Escherichia coli

Wang, H., Xu, Q., Chen, K., Chan, B. K. W., Ye, L., Yang, X., Xie, M., Liu, X., Ni, H., Chan, E. W., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02528-21 · Cited by 18 · see citing works

Sequence Analysis of pKF3-70 in Klebsiella pneumoniae: Probable Origin from R100-Like Plasmid of Escherichia coli

Yi, H., Xi, Y., Liu, J., Wang, J., Wu, J., Xu, T., Chen, W., Chen, B., Lin, M., Wang, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008601 · Cited by 30 · see citing works

Additional file 14: of Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae

Lam, M., Wyres, K. L., Judd, L., Wick, R., Jenney, A., Brisse, S., & Holt, K. (2018) · Figshare · doi:10.6084/m9.figshare.7265444

Genetic diversity and evolution of the virulence plasmids encoding aerobactin and salmochelin in Klebsiella pneumoniae

Tian, D., Wang, M., Zhou, Y., Hu, D., Ou, H., & Jiang, X. (2021) · Virulence · doi:10.1080/21505594.2021.1924019 · Cited by 71 · see citing works

Deciphering Evolutional Mechanisms of Non-K1/K2 Hypervirulent Klebsiella pneumoniaePreprint

Xie, M., Yang, X., Xu, Q., Ye, L., Chen, K., Zheng, Z., Dong, N., Sun, Q., Shu, L., Gu, D., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3514609